Zobrazeno 1 - 10
of 205
pro vyhledávání: '"David L Spector"'
Autor:
Allen T Yu, Carmen Berasain, Sonam Bhatia, Keith Rivera, Bodu Liu, Frank Rigo, Darryl J Pappin, David L Spector
Publikováno v:
eLife, Vol 10 (2021)
Hepatocellular carcinoma, the most common type of liver malignancy, is one of the most lethal forms of cancer. We identified a long non-coding RNA, Gm19705, that is overexpressed in hepatocellular carcinoma and mouse embryonic stem cells. We named th
Externí odkaz:
https://doaj.org/article/72f24e0d4ca04037b061615c66b60f36
Autor:
Meng Amy Li, Paulo P Amaral, Priscilla Cheung, Jan H Bergmann, Masaki Kinoshita, Tüzer Kalkan, Meryem Ralser, Sam Robson, Ferdinand von Meyenn, Maike Paramor, Fengtang Yang, Caifu Chen, Jennifer Nichols, David L Spector, Tony Kouzarides, Lin He, Austin Smith
Publikováno v:
eLife, Vol 6 (2017)
Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute
Externí odkaz:
https://doaj.org/article/10bac2ec83364a588083e62380429289
Publikováno v:
PLoS Genetics, Vol 1, Iss 6, p e79 (2005)
Centromeres interact with the spindle apparatus to enable chromosome disjunction and typically contain thousands of tandemly arranged satellite repeats interspersed with retrotransposons. While their role has been obscure, centromeric repeats are epi
Externí odkaz:
https://doaj.org/article/b9fa7e4a14604a08ae2a7c793d9d7ae2
Autor:
Gayan I. Balasooriya, David L. Spector
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The authors use allele-specific single cell transcriptomic analysis to elucidate the establishment of monoallelic gene expression in the cardiac lineage. The findings emphasize the importance of allele-specific insight into gene regulation in develop
Externí odkaz:
https://doaj.org/article/4fa281e3589a49d5865246250e22cb33
Autor:
Kung-Chi Chang, Sarah D. Diermeier, Allen T. Yu, Lily D. Brine, Suzanne Russo, Sonam Bhatia, Habeeb Alsudani, Karen Kostroff, Tawfiqul Bhuiya, Edi Brogi, Darryl J. Pappin, C. Frank Bennett, Frank Rigo, David L. Spector
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
A group of long non-coding RNAs (lncRNAs), Mammary Tumor Associated RNA s 1-30 (MaTARs 1-30), are differentially expressed between mammary tumor cells and normal mammary epithelial cells. Here the authors report that MaTAR25 plays a role in breast ca
Externí odkaz:
https://doaj.org/article/6dafc61ca8e54b14af09f6dca2979a49
Publikováno v:
Journal of Computational Biology. 30:518-537
Phylogenetic methods are emerging as a useful tool to understand cancer evolutionary dynamics, including tumor structure, heterogeneity, and progression. Most currently used approaches utilize either bulk whole genome sequencing (WGS) or single-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76435d4a12929179c8bb5fff0afed24b
https://doi.org/10.1089/cmb.2022.0357
https://doi.org/10.1089/cmb.2022.0357
Autor:
Kung-Chi Chang, David L. Spector
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
We recently reported on the role of Mammary Tumor Associated RNA 25 (MaTAR25) in mammary tumor cell proliferation, migration, and invasion. MaTAR25 interacts with transcriptional activator protein Pur-beta (Purb) to regulate its downstream targets su
Externí odkaz:
https://doaj.org/article/3ced76a4a4ae48ad8d518de4d6d64827
Autor:
Gayan I. Balasooriya, David L. Spector
Publikováno v:
bioRxiv
Spatiotemporal gene regulation is fundamental to the biology of diploid cells. Therefore, effective communication between two alleles and their geometry in the nucleus is important. However, the mechanism that fine-tunes the expression from each of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977d25e1934244997903820096d8c0e7
https://doi.org/10.1101/2023.04.07.536031
https://doi.org/10.1101/2023.04.07.536031
Autor:
David L. Spector, Karen Kostroff, W. Richard McCombie, John E. Wilkinson, Arvind Rishi, David A. Tuveson, Dennis Plenker, Taehoon Ha, Jonathan Preall, Charles M. Perou, Cheng Fan, Peter Andrews, Kyle Brophy, Gayatri Arun, Payal Naik, Suzanne Russo, Melissa Kramer, Sonam Bhatia
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with poor patient outcomes, highlighting the unmet clinical need for targeted therapies and better model systems. Here, we developed and comprehensively characterized a diver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7831d204482321d36c6b78198616cb7e
https://doi.org/10.1158/0008-5472.c.6513885.v1
https://doi.org/10.1158/0008-5472.c.6513885.v1
Autor:
David L. Spector, Karen Kostroff, W. Richard McCombie, John E. Wilkinson, Arvind Rishi, David A. Tuveson, Dennis Plenker, Taehoon Ha, Jonathan Preall, Charles M. Perou, Cheng Fan, Peter Andrews, Kyle Brophy, Gayatri Arun, Payal Naik, Suzanne Russo, Melissa Kramer, Sonam Bhatia
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f4cafddb25df1cbd4b7f4d92bdf334
https://doi.org/10.1158/0008-5472.22431381
https://doi.org/10.1158/0008-5472.22431381