Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David L Sloane"'
Autor:
John C Lin, David Tsao, Paul Barras, Raul A Bastarrachea, Bob Boyd, Joyce Chou, Rodnie Rosete, Hua Long, Alison Forgie, Yasmina Abdiche, Jeanette Dilley, Jennifer Stratton, Carlos Garcia, David L Sloane, Anthony G Comuzzie, Arnon Rosenthal
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1900 (2008)
Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and
Externí odkaz:
https://doaj.org/article/6efe3da8a10f430793c6095c8907968a
Publikováno v:
Pharmaceutical Research. 17:967-973
Purpose. It is a common preconception that supercoiledplasmid DNA is more desirable for the transfection of cells that the relaxedform of the plasmid. This notion has led to the recommendation that aspecification for the minimum amount of plasmid in
Publikováno v:
Journal of Biological Chemistry. 271:25412-25418
Mammalian lipoxygenases have been implicated in the pathogenesis of several inflammatory disorders and are, therefore, important targets for drug discovery. Both plant and mammalian lipoxygenases catalyze the dioxygenation of polyunsaturated fatty ac
Autor:
David L. Sloane, Elliott Sigal
Publikováno v:
Annals of the New York Academy of Sciences. 744:99-106
The lipoxygenases comprise a family of fatty acid dioxygenases that are involved in a variety of inflammatory conditions. Various approaches have been taken in order to understand the different regiospecificities of the different lipoxygenases. Here
Publikováno v:
Nature. 354:149-152
THE three mammalian lipoxygenases are named according to the carbon position (5,12 or 15) at which they catalyse the oxygenation of arachidonic acid1; they are implicated in inflammatory disorders, for example 15-1ipoxy gen ase is induced in atherosc
Autor:
Carlos Ferrer García, Jennifer Stratton, Carole M. Loo, David Tsao, John C. Lin, Joyce Chou, Michael Hagen, Arnon Rosenthal, David L. Sloane, Heather Koenig Thomsen
Publikováno v:
Endocrinology. 149(3)
Mutations in the tyrosine kinase receptor trkB or in one of its natural ligands, brain-derived neurotrophic factor (BDNF), lead to severe hyperphagia and obesity in rodents and/or humans. Here, we show that peripheral administration of neurotrophin-4
Publikováno v:
Biotechnology and applied biochemistry. 36(1)
Quantitative assays for the characterization of multi-component lipopolyplexes and their individual constituents are crucial for determining the consistency of formulation protocols which are ultimately reflected in biological activity. Lipid-polycat
Autor:
Natalie Saldou, Regina Leung, David C. Swinney, On-Yee So, Kurt Jarnagin, Liliana E. Scarafia, David L. Sloane
Publikováno v:
Gene. 161(2)
Lanosterol 14α-demethylase (LDM) is a cytochrome P-450 enzyme in the biosynthetic pathway of cholesterol. As such, it represents a target for cholesterol-lowering drugs. Rat LDM (rLDM) has been purified from the livers of rats treated with cholestyr
Publikováno v:
Biochemistry. 34(21)
Mammalian 15-lipoxygenases undergo a characteristic self-inactivation. The oxygenation of a single methionine to methionine sulfoxide, by 13(S)-hydroperoxyoctadecadienoic acid (13-HPODE), was previously suggested as the cause of the inactivation of r
Publikováno v:
Protein engineering. 8(3)
Positional specificity determinants of human 15-lipoxygenase were examined by site-directed mutagenesis and by kinetic analysis of the wild-type and variant enzymes. By comparing conserved differences among sequences of 12- and 15-lipoxygenases, a sm