Zobrazeno 1 - 10
of 133
pro vyhledávání: '"David L Selwood"'
Autor:
Che C Colpitts, Sophie Ridewood, Bethany Schneiderman, Justin Warne, Keisuke Tabata, Caitlin F Ng, Ralf Bartenschlager, David L Selwood, Greg J Towers
Publikováno v:
eLife, Vol 9 (2020)
Counteracting innate immunity is essential for successful viral replication. Host cyclophilins (Cyps) have been implicated in viral evasion of host antiviral responses, although the mechanisms are still unclear. Here, we show that hepatitis C virus (
Externí odkaz:
https://doaj.org/article/c5ebac21d95640d5911709dfca419d5e
Publikováno v:
F1000Research, Vol 8 (2019)
Multiple sclerosis (MS) is a major cause of disability in young adults. Following an unknown trigger (or triggers), the immune system attacks the myelin sheath surrounding axons, leading to progressive nerve cell death. Antibodies and small-molecule
Externí odkaz:
https://doaj.org/article/987ba5416fc54f4f93f490d99db0775e
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157754 (2016)
Multiple sclerosis (MS) is a debilitating immune-mediated neurological disorder affecting young adults. MS is primarily relapsing-remitting, but neurodegeneration and disability accumulate from disease onset. The most commonly used mouse MS models ex
Externí odkaz:
https://doaj.org/article/cdbd215cf02a460ea7828eb7f991ce93
Autor:
Sofia Sisay, Gareth Pryce, Samuel J Jackson, Carolyn Tanner, Ruth A Ross, Gregory J Michael, David L Selwood, Gavin Giovannoni, David Baker
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76907 (2013)
Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the orphan G protein receptor fifty-five (GPR55). Studies using C57BL/10 and C57BL/6 (Cnr2 (tm1Zim)
Externí odkaz:
https://doaj.org/article/0d32f5bcecba45b6acecca178110bd73
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 972 (2023)
Big conductance calcium-activated (BK) channel openers can inhibit pathologically driven neural hyperactivity to control symptoms via hyperpolarizing signals to limit neural excitability. We hypothesized that BK channel openers would be neuroprotecti
Externí odkaz:
https://doaj.org/article/a0bc6b4340914182a86b60587a142640
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 1, Pp 151185- (2022)
The PINK1/Parkin pathway plays an important role in maintaining a healthy pool of mitochondria. Activation of this pathway can lead to apoptosis, mitophagy, or mitochondrial-derived vesicle formation, depending on the nature of mitochondrial damage.
Externí odkaz:
https://doaj.org/article/a72decf209254e4591dc8c307a7ce914
Publikováno v:
F1000Research, Vol 10 (2021)
Oligodendrocytes wrap multiple lamellae of their membrane, myelin, around axons of the central nervous system (CNS), to improve impulse conduction. Myelin synthesis is specialised and dynamic, responsive to local neuronal excitation. Subtle pathologi
Externí odkaz:
https://doaj.org/article/9810d00c370c4920b32bff4a8c35f151
Autor:
Clare Mills, Sandra A. Hemkemeyer, Zerin Alimajstorovic, Chantelle Bowers, Malihe Eskandarpour, John Greenwood, Virginia Calder, A. W. Edith Chan, Paul J. Gane, David L. Selwood, Karl Matter, Maria S. Balda
Publikováno v:
Cells, Vol 11, Iss 11, p 1733 (2022)
Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibr
Externí odkaz:
https://doaj.org/article/0936817314424d6bbc31162cfa0c23ff
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 972
Big conductance calcium-activated (BK) channel openers can inhibit pathologically driven neural hyperactivity to control symptoms via hyperpolarizing signals to limit neural excitability. We hypothesized that BK channel openers would be neuroprotecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::4baa5c1d25df2f57cedb96b18e1a4b20
Autor:
Robert J. Smith, Cristina Perez-Ternero, Daniel Conole, Capucine Martin, Samuel H. Myers, Adrian J. Hobbs, David L. Selwood
Publikováno v:
Journal of Medicinal Chemistry. 65:5495-5513
C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis, which is at least partly mediated through agonism of natriuretic peptide receptor C (NPR-C), and loss of this signaling has been associated with vascular dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffab2223d28030fa379fcc2bcd93b0f
https://doi.org/10.1021/acs.jmedchem.1c01974
https://doi.org/10.1021/acs.jmedchem.1c01974