Zobrazeno 1 - 10
of 153
pro vyhledávání: '"David L Narum"'
Autor:
Raianna F Fantin, Camila H Coelho, Anne D Berhe, Luisa M D Magalhães, Dhélio B Pereira, Nichole D Salinas, Niraj H Tolia, Chanaki Amaratunga, Seila Suon, Issaka Sagara, David L Narum, Ricardo T Fujiwara, Claudia Abejon, Antonio Campos-Neto, Patrick E Duffy, Lilian L Bueno
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011229 (2023)
Plasmodium vivax is a major challenge for malaria control due to its wide geographic distribution, high frequency of submicroscopic infections, and ability to induce relapses due to the latent forms present in the liver (hypnozoites). Deepening our k
Externí odkaz:
https://doaj.org/article/26aa9faa000e42a7ba66f1f241a67b4d
Autor:
Gunjan Arora, Geoffrey T Hart, Javier Manzella-Lapeira, Justin YA Doritchamou, David L Narum, L Michael Thomas, Joseph Brzostowski, Sumati Rajagopalan, Ogobara K Doumbo, Boubacar Traore, Louis H Miller, Susan K Pierce, Patrick E Duffy, Peter D Crompton, Sanjay A Desai, Eric O Long
Publikováno v:
eLife, Vol 7 (2018)
Antibodies acquired naturally through repeated exposure to Plasmodium falciparum are essential in the control of blood-stage malaria. Antibody-dependent functions may include neutralization of parasite–host interactions, complement activation, and
Externí odkaz:
https://doaj.org/article/457a8813d81c4843847f41ab69e26c6a
Autor:
Puthupparampil V Scaria, Beth Chen, Christopher G Rowe, David S Jones, Emma Barnafo, Elizabeth R Fischer, Charles Anderson, Nicholas J MacDonald, Lynn Lambert, Kelly M Rausch, David L Narum, Patrick E Duffy
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190312 (2017)
Chemical conjugation of polysaccharide to carrier proteins has been a successful strategy to generate potent vaccines against bacterial pathogens. We developed a similar approach for poorly immunogenic malaria protein antigens. Our lead candidates in
Externí odkaz:
https://doaj.org/article/2a694a1e2ca147cf9e3a3357db15e749
Autor:
Kawsar R Talaat, Ruth D Ellis, Janet Hurd, Autumn Hentrich, Erin Gabriel, Noreen A Hynes, Kelly M Rausch, Daming Zhu, Olga Muratova, Raul Herrera, Charles Anderson, David Jones, Joan Aebig, Sarah Brockley, Nicholas J MacDonald, Xiaowei Wang, Michael P Fay, Sara A Healy, Anna P Durbin, David L Narum, Yimin Wu, Patrick E Duffy
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163144 (2016)
Transmission-blocking vaccines (TBVs) that target sexual stage parasite development could be an integral part of measures for malaria elimination. Pfs25 is a leading TBV candidate, and previous studies conducted in animals demonstrated an improvement
Externí odkaz:
https://doaj.org/article/93a3af0304db4dbb8a1f1800b018de1b
Autor:
David S Jones, Christopher G Rowe, Beth Chen, Karine Reiter, Kelly M Rausch, David L Narum, Yimin Wu, Patrick E Duffy
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0138761 (2016)
A practical method is described for synthesizing conjugated protein nanoparticles using thioether (thiol-maleimide) cross-linking chemistry. This method fills the need for a reliable and reproducible synthesis of protein conjugate vaccines for precli
Externí odkaz:
https://doaj.org/article/7ae623226dd943ff8db6cde05f050114
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132560 (2015)
We have developed a peptide display platform based on VLPs of the RNA bacteriophage MS2 that combines the high immunogenicity of VLP display with affinity selection capabilities. Random peptides can be displayed on the VLP surface by genetically inse
Externí odkaz:
https://doaj.org/article/b5b2bfd3c8e0479eb191dd8987695642
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56326 (2013)
The malaria parasite, Plasmodium falciparum, and related parasites use a variety of proteins with Duffy-Binding Like (DBL) domains to bind glycoproteins on the surface of host cells. Among these proteins, the 175 kDa erythrocyte binding antigen, EBA-
Externí odkaz:
https://doaj.org/article/b987de2104104d20be6b8b87b8a41b3f
Autor:
Feng Qian, Karine Reiter, Yanling Zhang, Richard L Shimp, Vu Nguyen, Joan A Aebig, Kelly M Rausch, Daming Zhu, Lynn Lambert, Gregory E D Mullen, Laura B Martin, Carole A Long, Louis H Miller, David L Narum
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e36996 (2012)
Self-associated protein aggregates or cross-linked protein conjugates are, in general, more immunogenic than oligomeric or monomeric forms. In particular, the immunogenicity in mice of a recombinant malaria transmission blocking vaccine candidate, th
Externí odkaz:
https://doaj.org/article/2bbd36d8532e439a9dea4bb157f5660b
Autor:
Ruth D Ellis, Yimin Wu, Laura B Martin, Donna Shaffer, Kazutoyo Miura, Joan Aebig, Andrew Orcutt, Kelly Rausch, Daming Zhu, Anders Mogensen, Michael P Fay, David L Narum, Carole Long, Louis Miller, Anna P Durbin
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46094 (2012)
A Phase 1 dose escalating study was conducted in malaria naïve adults to assess the safety, reactogenicity, and immunogenicity of the blood stage malaria vaccine BSAM2/Alhydrogel®+ CPG 7909. BSAM2 is a combination of the FVO and 3D7 alleles of reco
Externí odkaz:
https://doaj.org/article/08b261c51ad94288869cff2c341fcb56
Autor:
B Kim Lee Sim, David L Narum, Rana Chattopadhyay, Adriana Ahumada, J David Haynes, Steven R Fuhrmann, Jennifer N Wingard, Hong Liang, J Kathleen Moch, Stephen L Hoffman
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18393 (2011)
The malaria parasite Plasmodium falciparum EBA-175 binds its receptor sialic acids on glycophorin A when invading erythrocytes. The receptor-binding region (RII) contains two cysteine-rich domains with similar cysteine motifs (F1 and F2). Functional
Externí odkaz:
https://doaj.org/article/35e4e1b5664b4a81873e4517b2968be5