Zobrazeno 1 - 10
of 58
pro vyhledávání: '"David L McLean"'
Publikováno v:
eLife, Vol 13 (2024)
Different speeds of locomotion require heterogeneous spinal populations, but a common mode of rhythm generation is presumed to exist. Here, we explore the cellular versus synaptic origins of spinal rhythmicity at different speeds by performing electr
Externí odkaz:
https://doaj.org/article/2290c0c588d743e5ad29cf3c1ccd531b
Publikováno v:
eLife, Vol 11 (2022)
Mixed electrical-chemical synapses potentially complicate electrophysiological interpretations of neuronal excitability and connectivity. Here, we disentangle the impact of mixed synapses within the spinal locomotor circuitry of larval zebrafish. We
Externí odkaz:
https://doaj.org/article/d12bdd90c1f24c4ea87c82b85fa8b250
Publikováno v:
eLife, Vol 6 (2017)
To study cerebellar activity during learning, we made whole-cell recordings from larval zebrafish Purkinje cells while monitoring fictive swimming during associative conditioning. Fish learned to swim in response to visual stimulation preceding tacti
Externí odkaz:
https://doaj.org/article/508c721596854210a4509708561ad998
Publikováno v:
The Journal of Neuroscience. 43:4062-4074
Navigation requires steering and propulsion, but how spinal circuits contribute to direction control during ongoing locomotion is not well understood. Here, we use drifting vertical gratings to evoke directed “fictive” swimming in intact but immo
Autor:
Evdokia Menelaou, David L. McLean
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
V2a excitatory interneurons in the spinal cord are important for coordinating locomotion. Here the authors describe two types of V2a neuron with differences in higher order and lower order connectivity in larval zebrafish.
Externí odkaz:
https://doaj.org/article/1a5e0fb8086845d7988de4f4f4743a66
Autor:
Michael Jay, David L. McLean
Publikováno v:
Current Biology. 31:R1035-R1037
Summary Locomotion requires the segmental coordination of activity along the body. A new study in zebrafish reveals that spinal inhibitory interneurons are wired to execute different functions depending on whether their targets are nearby or further
Publikováno v:
The Journal of Neuroscience. 40:3063-3074
The cerebellum influences motor control through Purkinje target neurons, which transmit cerebellar output. Such output is required, for instance, for larval zebrafish to learn conditioned fictive swimming. The output cells, called eurydendroid neuron
Autor:
David L, McLean
Publikováno v:
Neuron
Motor systems must continuously adapt their output to maintain a desired trajectory. While the spinal circuits underlying rhythmic locomotion are well described, little is known about how the network modulates its output strength. A major challenge h
We present an open access scanned oblique plane microscopy platform Crossbill. It combines a new optical configuration, open hardware assembly, a systematic alignment protocol, and dedicated control software to provide a compact, versatile, high reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db771b569cbd2a5b770c827d6a8049a9
https://doi.org/10.1101/2021.04.30.442190
https://doi.org/10.1101/2021.04.30.442190