Zobrazeno 1 - 10
of 83
pro vyhledávání: '"David L Hasty"'
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47333 (2012)
Lipoteichoic acid (LTA) is a Gram-positive cell surface molecule that is found in both a cell-bound form and cell-free form in the host during an infection. Hemoglobin (Hb) can synergize with LTA, a TLR2 ligand, to potently activate macrophage innate
Externí odkaz:
https://doaj.org/article/dcff9adfe3e149409a7ba03e33929dcf
Autor:
Harry S Courtney, Itzhak Ofek, Thomas Penfound, Victor Nizet, Morgan A Pence, Bernd Kreikemeyer, Andreas Podbielski, David L Hasty, James B Dale
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4166 (2009)
BackgroundHydrophobicity is an important attribute of bacteria that contributes to adhesion and biofilm formation. Hydrophobicity of Streptococcus pyogenes is primarily due to lipoteichoic acid (LTA) on the streptococcal surface but the mechanism(s)
Externí odkaz:
https://doaj.org/article/c25d60e84c374d7ea659406e8a7a68d0
Autor:
Kathleen H Cox, Eduardo Ruiz-Bustos, Harry S Courtney, James B Dale, Morgan A Pence, Victor Nizet, Ramy K Aziz, Ivan Gerling, Susan M Price, David L Hasty
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5366 (2009)
D-alanylated lipoteichoic acid is a virtually ubiquitous component of gram-positive cell walls. Mutations in the dltABCD operon of numerous species exhibit pleiotropic effects, including reduced virulence, which has been attributed to increased bindi
Externí odkaz:
https://doaj.org/article/87f2912cde864adc898d85a607b53dca
Publikováno v:
The Journal of Infectious Diseases. 201:1580-1588
BACKGROUND The NH(2)-terminal sequence of the M protein from group A streptococci defines the serotype of the organism and contains epitopes that evoke bactericidal antibodies. METHODS To identify additional roles for this region of the M protein, we
Publikováno v:
Infection and Immunity. 75:2638-2641
Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases of interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 sec
Publikováno v:
International Congress Series. 1289:195-198
M type 4 Streptococcus pyogenes is a frequent cause of infections, yet little is known concerning its anti-phagocytic factors. We investigated the role of the Mga regulon on growth in blood by inactivating individual genes within this regulon. Ablati
Publikováno v:
Molecular Microbiology. 59:936-947
A key attribute of invasive Streptococcus pyogenes is their ability to resist phagocytosis and multiply in human blood. M-related protein (Mrp) is a major anti-phagocytic factor but the mechanism whereby it helps streptococci to evade phagocytosis ha
Publikováno v:
Annals of the New York Academy of Sciences. 963:332-335
The local cytokine response to uropathogenic phenotype Escherichia coli KBC211 infection exhibits characteristics of both TH1 and TH2 profiles. Interleukin (IL)-6, MIP-2, IL-12, IL-18, and tumor necrosis factor-alpha (TNF-alpha) are expressed, but IL
Publikováno v:
FEMS Microbiology Letters. 151:65-70
We investigated the contributions of lipoteichoic acid and M protein to reversible and irreversible adhesion of group A streptococci and the effects of such adhesion on release of interleukin-6. Streptococci in which lipoteichoic acid was masked by t