Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts

Autor: Georgios Baskozos, Andreas C. Themistocleous, Harry L. Hebert, Mathilde M. V. Pascal, Jishi John, Brian C. Callaghan, Helen Laycock, Yelena Granovsky, Geert Crombez, David Yarnitsky, Andrew S. C. Rice, Blair H. Smith, David L. H. Bennett

Publikováno v: BMC Medical Informatics and Decision Making, Vol 22, Iss 1, Pp 1-23 (2022)

Abstract Background To improve the treatment of painful Diabetic Peripheral Neuropathy (DPN) and associated co-morbidities, a better understanding of the pathophysiology and risk factors for painful DPN is required. Using harmonised cohorts (N = 1230

Externí odkaz: https://doaj.org/article/513bcb9d16054d3ea31fc23f765b2be5

Cohort profile: DOLORisk Dundee: a longitudinal study of chronic neuropathic pain

Autor: Claire Jones, Blair H. Smith, Geert Crombez, Harry L. Hébert, Abirami Veluchamy, Georgios Baskozos, Francesca Fardo, Dimitri M. L. Van Ryckeghem, Mathilde M. V. Pascal, Keith Milburn, Ewan R. Pearson, David L. H. Bennett, Weihua Meng, Colin N. A. Palmer

Publikováno v: BMJ Open, Vol 11, Iss 5 (2021)

Purpose Neuropathic pain is a common disorder of the somatosensory system that affects 7%–10% of the general population. The disorder places a large social and economic burden on patients as well as healthcare services. However, not everyone with a

Externí odkaz: https://doaj.org/article/3238e094b5294790bb9a30bd61dc080e

Axonal Excitability Does Not Differ between Painful and Painless Diabetic or Chemotherapy‐Induced Distal Symmetrical Polyneuropathy in a Multicenter Observational Study

Autor: Andreas C. Themistocleous, Alexander G. Kristensen, Roma Sola, Sandra S. Gylfadottir, Kristine Bennedsgaard, Mustapha Itani, Thomas Krøigård, Lise Ventzel, Søren H. Sindrup, Troels S. Jensen, Hugh Bostock, Jordi Serra, Nanna B. Finnerup, Hatice Tankisi, David L. H. Bennett

Publikováno v: Themistocleous, A C, Kristensen, A G, Sola, R, Gylfadottir, S S, Bennedsgaard, K, Itani, M, Krøigård, T, Ventzel, L, Sindrup, S H, Jensen, T S, Bostock, H, Serra, J, Finnerup, N B, Tankisi, H & Bennett, D L H 2022, ' Axonal Excitability Does Not Differ between Painful and Painless Diabetic or Chemotherapy-Induced Distal Symmetrical Polyneuropathy in a Multicenter Observational Study ', Annals of Neurology, vol. 91, no. 4, pp. 506-520 . https://doi.org/10.1002/ana.26319

Objective: Axonal excitability reflects ion channel function, and it is proposed that this may be a biomarker in painful (vs painless) polyneuropathy. Our objective was to investigate the relationship between axonal excitability parameters and chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc09a7cf06b51c26482a3670865ef497
https://doi.org/10.1002/ana.26319

Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain:a DOLORisk Dundee study

Autor: Harry L. Hébert, Abirami Veluchamy, Georgios Baskozos, Francesca Fardo, Dimitri Van Ryckeghem, Ewan R. Pearson, Lesley A. Colvin, Geert Crombez, David L. H. Bennett, Weihua Meng, Colin N. A. Palmer, Blair H. Smith

Publikováno v: Hébert, H L, Veluchamy, A, Baskozos, G, Fardo, F, Van Ryckeghem, D, Pearson, E R, Colvin, L A, Crombez, G, Bennett, D L H, Meng, W, Palmer, C N A & Smith, B H 2022, ' Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain : a DOLORisk Dundee study ', Journal of Neurology . https://doi.org/10.1007/s00415-022-11478-0
JOURNAL OF NEUROLOGY
Journal of Neurology, 270(2), 1076-1094. Springer
Hébert, H L, Veluchamy, A, Baskozos, G, Fardo, F, Van Ryckeghem, D, Pearson, E R, Colvin, L A, Crombez, G, Bennett, D L H, Meng, W, Palmer, C N A & Smith, B H 2023, ' Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain : a DOLORisk Dundee study ', Journal of Neurology, vol. 270, no. 2, pp. 1076-1094 . https://doi.org/10.1007/s00415-022-11478-0

Neuropathic pain is difficult to treat, and an understanding of the risk factors for its onset and resolution is warranted. This study aimed to develop and externally validate two clinical risk models to predict onset and resolution of chronic neurop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b80324bee44f1fe3004a985ef357ef
https://hdl.handle.net/20.500.11820/ada687e9-35e0-473e-b7a9-0daac2769f19

Acute small fiber neuropathy after Oxford-AstraZeneca ChAdOx1-S vaccination: A report of three cases and review of the literature

Autor: Molly G, Abbott, Zahra, Allawi, Monika, Hofer, Olaf, Ansorge, Stefen, Brady, Ricardo, Fadic, Gustavo, Torres, Ravi, Knight, Margarita, Calvo, David L H, Bennett, Andreas C, Themistocleous

Publikováno v: Journal of the peripheral nervous system : JPNSREFERENCES. 27(4)

Small fiber neuropathy usually presents with gradual and progressive chronic length-dependent pain. Acute small fiber neuropathy is rarely reported. Three patients with acute onset neuropathic pain after Oxford-AstraZeneca ChAdOx1-S vaccination are d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cf4fb87acd621144fcbff5c30ba4380
https://pubmed.ncbi.nlm.nih.gov/35962630