Zobrazeno 1 - 10
of 62
pro vyhledávání: '"David L Deitcher"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 5 (2022)
AbstractInsect body color is an easily assessed and visually engaging trait that is informative on a broad range of topics including speciation, biomaterial science, and ecdysis. Mutants of the fruit fly Drosophila melanogastersable1Yippeesable1Yippe
Externí odkaz:
https://doaj.org/article/fca7943a518c42e883a268c94001840c
Autor:
Dinara Bulgari, Samantha L. Cavolo, Brigitte F. Schmidt, Katherine Buchan, Marcel P. Bruchez, David L. Deitcher, Edwin S. Levitan
Neuronal dense-core vesicles (DCVs) contain neuropeptides and much larger proteins that affect synaptic growth and plasticity. Rather than using full collapse exocytosis that is common in endocrine cells, DCVs at a native intact synapse, theDrosophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97da64bd3ae2687d717cccfea0109243
https://doi.org/10.1101/2022.12.24.521856
https://doi.org/10.1101/2022.12.24.521856
Publikováno v:
Proc Natl Acad Sci U S A
Neuropeptides control rhythmic behaviors, but the timing and location of their release within circuits is unknown. Here imaging in the brain shows that synaptic neuropeptide release by Drosophila clock neurons is diurnal, peaking at times of day that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1194d5387bc7077bcebe54f0c052c9
https://pubmed.ncbi.nlm.nih.gov/33875606
https://pubmed.ncbi.nlm.nih.gov/33875606
Autor:
David L. Deitcher, Seema Amin, Derek M. Dean, Casey Jarvis, Emma McAvoy, Andrew Recknagel, Ronald R. Hoy, Breelyn Karno, Hannah Weinstein
Publikováno v:
Fly. 12:55-61
The bang-sensitive (BS) mutants of Drosophila are an important model for studying epilepsy. We recently identified a novel BS locus, julius seizure (jus), encoding a protein containing two transmembrane domains and an extracellular cysteine-rich loop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16e23242b1bf0f649aae22475e576e8
https://doi.org/10.1080/19336934.2017.1402993
https://doi.org/10.1080/19336934.2017.1402993
Publikováno v:
European Journal of Cell Biology. 96:402-406
The Huntington’s disease protein Huntingtin (Htt) regulates axonal transport of dense-core vesicles (DCVs) containing neurotrophins and neuropeptides. DCVs travel down axons to reach nerve terminals where they are either captured in synaptic bouton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1392851804efa28c824059e9eaa0dc52
https://doi.org/10.1016/j.ejcb.2017.01.001
https://doi.org/10.1016/j.ejcb.2017.01.001
Autor:
Edwin S. Levitan, Marcel P. Bruchez, Brigitte F. Schmidt, M Alexandra Carpenter, Dinara Bulgari, Christopher Szent-Gyorgyi, David L. Deitcher
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(34)
Synaptic release of neuropeptides packaged in dense-core vesicles (DCVs) regulates synapses, circuits, and behaviors including feeding, sleeping, and pain perception. Here, synaptic DCV fusion pore openings are imaged without interference from cotran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55342803f7365c76bf1e25ad983730a8
https://pubmed.ncbi.nlm.nih.gov/31383765
https://pubmed.ncbi.nlm.nih.gov/31383765
Publikováno v:
The Journal of Neuroscience. 36:11781-11787
Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out of the nerve terminal. Activity increases DCV capture to rapidly replenish synaptic neuropep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d86b7d91efd034f21ede609a9681a2
https://doi.org/10.1523/jneurosci.2212-16.2016
https://doi.org/10.1523/jneurosci.2212-16.2016
Autor:
Derek M. Dean, Sarah Cottrill, Luana S. Maroja, Brent E. Bomkamp, David L. Deitcher, Kathleen A. Westervelt
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 2, Pp 299-310 (2016)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b22d56600e45ec2b5b5e5e4063f59a
http://g3journal.org/lookup/doi/10.1534/g3.115.024307
http://g3journal.org/lookup/doi/10.1534/g3.115.024307
Autor:
Juan Tao, Hector J Fonseca Velez, Drew A Berkhoudt, Dinara Bulgari, Nadezhda S. Sabeva, Edwin S. Levitan, Simon C. Watkins, Michael J. Calderon, David L. Deitcher
Publikováno v:
Journal of Cell Science.
Many neurons influence their targets through co-release of neuropeptides and small-molecule transmitters. Neuropeptides are packaged into dense-core vesicles (DCVs) in the soma and then transported to synapses, while small-molecule transmitters such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e5436a7b926f65e427d4b1e301a5470
https://doi.org/10.1242/jcs.224568
https://doi.org/10.1242/jcs.224568
Publikováno v:
Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience. 16(3)
Optogenetics is possibly the most revolutionary advance in neuroscience research techniques within the last decade. Here, we describe lab modules, presented at a workshop for undergraduate neuroscience educators, using optogenetic control of neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d73bdafaaafbf4ac829cc2848a385148
https://pubmed.ncbi.nlm.nih.gov/30254546
https://pubmed.ncbi.nlm.nih.gov/30254546