Zobrazeno 1 - 10
of 246
pro vyhledávání: '"David L Brody"'
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276107 (2022)
The blood-brain barrier (BBB) presents a major obstacle in developing specific diagnostic imaging agents for many neurological disorders. In this study we aimed to generate single domain anti-mouse transferrin receptor antibodies (anti-mTfR VHHs) to
Externí odkaz:
https://doaj.org/article/c3c59ea937e54ad8b5541ab9906e1211
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259335 (2021)
Alzheimer's disease (AD) is tightly correlated with synapse loss in vulnerable brain regions. It is assumed that specific molecular entities such as Aβ and tau cause synapse loss in AD, yet unbiased screens for synaptotoxic activities have not been
Externí odkaz:
https://doaj.org/article/022bb368d84f4c268f73494fc6f10c44
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200251 (2018)
An unanswered question regarding Alzheimer disease dementia (ADD) is whether amyloid-beta (Aβ) plaques sequester toxic soluble Aβ species early during pathological progression. We previously reported that the concentration of soluble Aβ aggregates
Externí odkaz:
https://doaj.org/article/732a7baf5e4048b88aae97bc001ea5af
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74510 (2013)
The debilitating effects of repetitive concussive traumatic brain injury (rcTBI) have been increasingly recognized in both military and civilian populations. rcTBI may result in significant neurological, cognitive, and affective sequelae, and is ofte
Externí odkaz:
https://doaj.org/article/fb994f8ea040409aa8589461bd0f8cc8
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64078 (2013)
Posttraumatic epilepsy is a major source of disability following traumatic brain injury (TBI) and a common cause of medically-intractable epilepsy. Previous attempts to prevent the development of posttraumatic epilepsy with treatments administered im
Externí odkaz:
https://doaj.org/article/9148b105b8f44b3d9b0bb8a2b0783f67
Autor:
Christine Mac Donald, Ann Johnson, Dana Cooper, Thomas Malone, James Sorrell, Joshua Shimony, Matthew Parsons, Abraham Snyder, Marcus Raichle, Raymond Fang, Stephen Flaherty, Michael Russell, David L Brody
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55823 (2013)
Little is known about the effects of blast exposure on the human brain in the absence of head impact. Clinical reports, experimental animal studies, and computational modeling of blast exposure have suggested effects on the cerebellum and brainstem.
Externí odkaz:
https://doaj.org/article/8ee8332de6fc4f93917886d25cb90d43
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25475 (2011)
Traumatic brain injury (TBI) is a major environmental risk factor for Alzheimer's disease. Intracellular accumulations of amyloid-β and tau proteins have been observed within hours following severe TBI in humans. Similar abnormalities have been reca
Externí odkaz:
https://doaj.org/article/0d3960c238fc467f9ac6c6c721ba15a0
Autor:
Sharon Y. Kim, Alyssa A. Soumoff, Sorana Raiciulescu, Patricia A. Kemezis, Elizabeth A. Spinks, David L. Brody, Vincent F. Capaldi, Robert J. Ursano, David M. Benedek, Kwang H. Choi
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 14-24 (2023)
The impact of traumatic brain injury (TBI) severity and loss of consciousness (LOC) on the development of neuropsychiatric symptoms was studied in injured service members (SMs; n?=?1278) evacuated from combat settings between 2003 and 2012. TBI diagn
Externí odkaz:
https://doaj.org/article/60d934b0c88340998b4cef993073fafa
Autor:
David L Brody MD, PhD
This is a practical manual for clinicians who take care of patients with concussions. The long-term effects of concussions are an increasingly recognized problem in the medical community and by the general public. Most people recover well from concus
Publikováno v:
Brain. 146:1212-1226
There are currently no non-invasive imaging methods available for astrogliosis assessment or mapping in the central nervous system despite its essential role in the response to many disease states, such as infarcts, neurodegenerative conditions, trau