Zobrazeno 1 - 10
of 201
pro vyhledávání: '"David L Boyle"'
Autor:
Hyeonjeong Lee, Camilla R L Machado, Deepa Hammaker, Eunice Choi, Edward B Prideaux, Wei Wang, David L Boyle, Gary S Firestein
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304530 (2024)
Rheumatoid arthritis (RA) is a systemic immune-mediated disease characterized by joint inflammation and destruction. The disease typically affects small joints in the hands and feet, later progressing to involve larger joints such as the knees, shoul
Externí odkaz:
https://doaj.org/article/2b85a7c05bcd4e318c6f0ff23d6ac2bb
Autor:
John W Whitaker, David L Boyle, Beatrix Bartok, Scott T Ball, Steffen Gay, Wei Wang, Gary S Firestein
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124254 (2015)
Identifying novel therapeutic targets for the treatment of disease is challenging. To this end, we developed a genome-wide approach of candidate gene prioritization. We independently collocated sets of genes that were implicated in rheumatoid arthrit
Externí odkaz:
https://doaj.org/article/b794fd9002ac4f4ba1d969942a72426a
Autor:
John W Whitaker, David L Boyle, Beatrix Bartok, Scott T Ball, Steffen Gay, Wei Wang, Gary S Firestein
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136334 (2015)
Externí odkaz:
https://doaj.org/article/0d8f76868510409fb98a362a63b34ab1
Autor:
David L Boyle, Deepa Hammaker, Meghan Edgar, Mario M Zaiss, Stefan Teufel, Jean Pierre David, Georg Schett, Gary S Firestein
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84818 (2014)
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix deposition and mineralization. Bone homeostasis is altered in chronic inflammation as well as in post-menopausal loss of estrogen, which favors osteoclast act
Externí odkaz:
https://doaj.org/article/7ff73580ae4f4c59b9d4e9fe19c65f5b
Autor:
David L Boyle, Toni L Jones, Deepa Hammaker, Camille I Svensson, Sanna Rosengren, Salvatore Albani, Linda Sorkin, Gary S Firestein
Publikováno v:
PLoS Medicine, Vol 3, Iss 9, p e338 (2006)
Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined. Previous studies
Externí odkaz:
https://doaj.org/article/5ac484a5a9204e158d78347fa34b8529
Autor:
Richard I. Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology. Here the authors use a Taiji computational approach to analyze gene expr
Externí odkaz:
https://doaj.org/article/c8daa11cab114d9a8d1dd398242e20b7
Autor:
Cecilia Ansalone, Richard I. Ainsworth, Gyrid Nygaard, Rizi Ai, Edward B. Prideaux, Deepa Hammaker, Narayanan B. Perumal, Ken Weichert, Frances Tung, Lalitha Kodandapani, J. Michael Sauder, Elisabeth C. Mertsching, Robert J. Benschop, David L. Boyle, Wei Wang, Gary S. Firestein
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 4, Pp 288-299 (2022)
Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype. We i
Externí odkaz:
https://doaj.org/article/7bf9364f9ed048b68c6e9061d4e747da
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 3, Pp 127-132 (2021)
Objective To study epigenetic patterns in T lymphocytes that accumulate in the rheumatoid arthritis (RA) synovium, we characterized DNA methylation of CD3+ T cells in peripheral blood and synovial tissue in patients with RA and osteoarthritis (OA). M
Externí odkaz:
https://doaj.org/article/0ec85da48b6d4848bc62be3cdc245ff4
Autor:
Hannah A. Nonoguchi, Timothy Wee Shang Kouo, Sandhya Kortagere, Joshua Hillman, David L. Boyle, Chitra D. Mandyam
Publikováno v:
Brain Sciences, Vol 12, Iss 8, p 972 (2022)
Humans and rodents have sexually dimorphic immune responses, which could influence the brain’s response to a systemic inflammatory insult. Lipopolysaccharide (LPS) is a stimulator of the innate immune system and is routinely used in animal models t
Externí odkaz:
https://doaj.org/article/4ab83c0b3c6945c981352160a16b4242
Autor:
Rizi Ai, Teresina Laragione, Deepa Hammaker, David L. Boyle, Andre Wildberg, Keisuke Maeshima, Emanuele Palescandolo, Vinod Krishna, David Pocalyko, John W. Whitaker, Yuchen Bai, Sunil Nagpal, Kurtis E. Bachman, Richard I. Ainsworth, Mengchi Wang, Bo Ding, Percio S. Gulko, Wei Wang, Gary S. Firestein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA). Here the authors integrate a variety of epigenomic data to map the epigenome of FLS in RA an
Externí odkaz:
https://doaj.org/article/5335c5581683468bbfffd411af6416a5