Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David L Aylor"'
Autor:
Lisa E Gralinski, Martin T Ferris, David L Aylor, Alan C Whitmore, Richard Green, Matthew B Frieman, Damon Deming, Vineet D Menachery, Darla R Miller, Ryan J Buus, Timothy A Bell, Gary A Churchill, David W Threadgill, Michael G Katze, Leonard McMillan, William Valdar, Mark T Heise, Fernando Pardo-Manuel de Villena, Ralph S Baric
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005504 (2015)
New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically diverse animals from incipient lines of the Collaborative Cross mouse panel, we demonstrate a gre
Externí odkaz:
https://doaj.org/article/b8f7d6c3b6f74bfd8dd8a1fd634eea07
Autor:
John P Didion, Andrew P Morgan, Amelia M-F Clayshulte, Rachel C Mcmullan, Liran Yadgary, Petko M Petkov, Timothy A Bell, Daniel M Gatti, James J Crowley, Kunjie Hua, David L Aylor, Ling Bai, Mark Calaway, Elissa J Chesler, John E French, Thomas R Geiger, Terry J Gooch, Theodore Garland, Alison H Harrill, Kent Hunter, Leonard McMillan, Matt Holt, Darla R Miller, Deborah A O'Brien, Kenneth Paigen, Wenqi Pan, Lucy B Rowe, Ginger D Shaw, Petr Simecek, Patrick F Sullivan, Karen L Svenson, George M Weinstock, David W Threadgill, Daniel Pomp, Gary A Churchill, Fernando Pardo-Manuel de Villena
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004850 (2015)
Significant departures from expected Mendelian inheritance ratios (transmission ratio distortion, TRD) are frequently observed in both experimental crosses and natural populations. TRD on mouse Chromosome (Chr) 2 has been reported in multiple experim
Externí odkaz:
https://doaj.org/article/53c2f98bb98349e2a1907e6090291e44
Autor:
Martin T Ferris, David L Aylor, Daniel Bottomly, Alan C Whitmore, Lauri D Aicher, Timothy A Bell, Birgit Bradel-Tretheway, Janine T Bryan, Ryan J Buus, Lisa E Gralinski, Bart L Haagmans, Leonard McMillan, Darla R Miller, Elizabeth Rosenzweig, William Valdar, Jeremy Wang, Gary A Churchill, David W Threadgill, Shannon K McWeeney, Michael G Katze, Fernando Pardo-Manuel de Villena, Ralph S Baric, Mark T Heise
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003196 (2013)
Genetic variation contributes to host responses and outcomes following infection by influenza A virus or other viral infections. Yet narrow windows of disease symptoms and confounding environmental factors have made it difficult to identify polymorph
Externí odkaz:
https://doaj.org/article/7b65541d5dda41df84e78d9a797b012a
Autor:
David L Aylor, Zhao-Bang Zeng
Publikováno v:
PLoS Genetics, Vol 4, Iss 3, p e1000029 (2008)
Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which is the interaction between alleles at different
Externí odkaz:
https://doaj.org/article/043c735d47b148bfa7a0af6237b4da9e
Publikováno v:
Am J Hum Genet
Ischemic stroke, caused by vessel blockage, results in cerebral infarction, the death of brain tissue. Previously, quantitative trait locus (QTL) mapping of cerebral infarct volume and collateral vessel number identified a single, strong genetic locu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d72cc72617d917ae67fb2c7036b244
https://europepmc.org/articles/PMC9606478/
https://europepmc.org/articles/PMC9606478/
Autor:
Shannah K. Witchey, Michael G. Doyle, Jacob D. Fredenburg, Genevieve St. Armour, Brian Horman, Melanie T. Odenkirk, David L. Aylor, Erin S. Baker, Heather B. Patisaul
Publikováno v:
Neuroendocrinology.
Introduction: Flame retardants (FRs) are common bodily and environmental pollutants, creating concern about their potential toxicity. We and others have found that the commercial mixture, FireMaster® 550 (FM 550) or its individual brominated (BFR) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164554604087c45a1f9b2eabe474a064
https://doi.org/10.1159/000526959
https://doi.org/10.1159/000526959
Publikováno v:
Genetics
Hybrid male sterility (HMS) contributes to reproductive isolation commonly observed among house mouse (Mus musculus) subspecies, both in the wild and in laboratory crosses. Incompatibilities involving specific Prdm9 alleles and certain Chromosome (Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d8193cd5c3f5bd6fc424d3dd984ef8
https://doi.org/10.1534/genetics.120.303474
https://doi.org/10.1534/genetics.120.303474
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience, Vol 15 (2021)
Ischemic stroke is caused by a disruption of the blood supply to the brain leading to neuronal cell death. Genetic studies of ischemic stroke have identified numerous gene variants that increase the risk to develop stroke. In stark contrast, genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7588ef23fd24525bfbbc013cee3d439
https://pubmed.ncbi.nlm.nih.gov/34408625
https://pubmed.ncbi.nlm.nih.gov/34408625
Autor:
Andrew Hillhouse, Kranti Konganti, David L. Aylor, Francis Swift-Haire, David W. Threadgill, Thomas Konneker, Drake Phelps, Tiffany A. Garbutt, Alexis Jones
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Mus musculus is the only known species from which embryonic stem cells (ESC) can be isolated under conditions requiring only leukemia inhibitory factor (LIF). Other species are non-permissive in LIF media, and form developmentally primed epiblast ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2671f0f2d8857306ef46d3d976fe4c2b
http://link.springer.com/article/10.1038/s41598-018-32116-8
http://link.springer.com/article/10.1038/s41598-018-32116-8
Publikováno v:
Best Practice & Research Clinical Endocrinology & Metabolism. 32:283-297
Endocrine disrupting chemicals (EDCs) are compounds that alter the structure and function of the endocrine system and may be contributing to disorders of the reproductive, metabolic, neuroendocrine and other complex systems. Typically, these outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077281bd658550f883b0be837c1d27d9
https://doi.org/10.1016/j.beem.2018.03.011
https://doi.org/10.1016/j.beem.2018.03.011