Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David Lähnemann"'
Autor:
Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, David Lähnemann, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Steven A. Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T. Siveke
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-22 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essentially all targeted t
Externí odkaz:
https://doaj.org/article/d600d9b4f409474cb363cc7b8d335cf3
Autor:
David Lähnemann, Johannes Köster, Ute Fischer, Arndt Borkhardt, Alice C. McHardy, Alexander Schönhuth
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Obtaining accurate variant calls from multiple displacement amplified single cell DNA sequencing data needs dedicated models that account for amplification bias and copy errors. Here, the authors describe ProSolo, a model for calling single nucleotid
Externí odkaz:
https://doaj.org/article/8db091b26b934b4bafe06184a93555fe
Autor:
David Lähnemann, Johannes Köster, Ewa Szczurek, Davis J. McCarthy, Stephanie C. Hicks, Mark D. Robinson, Catalina A. Vallejos, Kieran R. Campbell, Niko Beerenwinkel, Ahmed Mahfouz, Luca Pinello, Pavel Skums, Alexandros Stamatakis, Camille Stephan-Otto Attolini, Samuel Aparicio, Jasmijn Baaijens, Marleen Balvert, Buys de Barbanson, Antonio Cappuccio, Giacomo Corleone, Bas E. Dutilh, Maria Florescu, Victor Guryev, Rens Holmer, Katharina Jahn, Thamar Jessurun Lobo, Emma M. Keizer, Indu Khatri, Szymon M. Kielbasa, Jan O. Korbel, Alexey M. Kozlov, Tzu-Hao Kuo, Boudewijn P.F. Lelieveldt, Ion I. Mandoiu, John C. Marioni, Tobias Marschall, Felix Mölder, Amir Niknejad, Alicja Rączkowska, Marcel Reinders, Jeroen de Ridder, Antoine-Emmanuel Saliba, Antonios Somarakis, Oliver Stegle, Fabian J. Theis, Huan Yang, Alex Zelikovsky, Alice C. McHardy, Benjamin J. Raphael, Sohrab P. Shah, Alexander Schönhuth
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Abstract The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands—or even millions—of cells analyzed in a single experiment amount to a
Externí odkaz:
https://doaj.org/article/9368dc7f34b5489abc7fc8743d7a022d
Autor:
David Lähnemann, Alice C. McHardy, Alexander Schönhuth, Johannes Köster, Ute Fischer, Arndt Borkhardt
Obtaining accurate mutational profiles from single cell DNA is essential for the analysis of genomic cell-to-cell heterogeneity at the finest level of resolution. However, sequencing libraries suitable for genotyping require whole genome amplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ee4f372fb2a504c9388343ee4ff89d
https://doi.org/10.1101/2020.04.27.064071
https://doi.org/10.1101/2020.04.27.064071
Autor:
Catalina A. Vallejos, Samuel Aparicio, Emma M. Keizer, Ion I. Mandoiu, Luca Pinello, Huan Yang, Maria Florescu, Camille Stephan Otto Attolini, Marcel J. T. Reinders, Ewa Szczurek, Ahmed Mahfouz, Alexandros Stamatakis, Jasmijn A. Baaijens, Amir Niknejad, Rens Holmer, Tzu Hao Kuo, Benjamin J. Raphael, Felix Mölder, Alexey M. Kozlov, Giacomo Corleone, Alexander Zelikovsky, Bas E. Dutilh, Alexander Schönhuth, Antoine-Emmanuel Saliba, Davis J. McCarthy, Sohrab P. Shah, Mark D. Robinson, Johannes Köster, David Lähnemann, Pavel Skums, Boudewijn P. F. Lelieveldt, Antonio Cappuccio, Jeroen de Ridder, Niko Beerenwinkel, Antonios Somarakis, Stephanie C. Hicks, Lukasz Raczkowski, Kieran R Campbell, John C. Marioni, Thamar Jessurun Lobo, Marleen Balvert, Oliver Stegle, Katharina Jahn, Indu Khatri, Jan O. Korbel, Tobias Marschall, Alice C. McHardy, Szymon M. Kielbasa, Fabian J. Theis, Victor Guryev, Buys de Barbanson
Publikováno v:
Genome Biology, 21, 1-31
Genome Biology
Genome Biology, 21(1). BioMed Central
Genome Biology 21 (2020) 1
Genome Biology, 21, 31
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Genome biology, 21 (1), Article: 31
Genome Biology, 21(1). BMC
Genome Biology, 21(1)
Genome Biology, 21, 31. BMC
Genome Biol. 21:31 (2020)
Genome Biology, 21, 1, pp. 31
Genome biology
Lähnemann, D, Köster, J, Szczurek, E, McCarthy, D J, Hicks, S C, Robinson, M D, Vallejos, C A, Campbell, K R, Beerenwinkel, N, Mahfouz, A, Pinello, L, Skums, P, Stamatakis, A, Attolini, C S-O, Aparicio, S, Baaijens, J, Balvert, M, Barbanson, B D, Cappuccio, A, Corleone, G, Dutilh, B E, Florescu, M, Guryev, V, Holmer, R, Jahn, K, Lobo, T J, Keizer, E M, Khatri, I, Kielbasa, S M, Korbel, J O, Kozlov, A M, Kuo, T-H, Lelieveldt, B P F, Mandoiu, I I, Marioni, J C, Marschall, T, Mölder, F, Niknejad, A, Raczkowski, L, Reinders, M, Ridder, J D, Saliba, A-E, Somarakis, A, Stegle, O, Theis, F J, Yang, H, Zelikovsky, A, McHardy, A C, Raphael, B J, Shah, S P & Schönhuth, A 2020, ' Eleven grand challenges in single-cell data science ', Genome Biology, vol. 21, no. 1, pp. 31 . https://doi.org/10.1186/s13059-020-1926-6
Genome Biology
Genome Biology, 21(1). BioMed Central
Genome Biology 21 (2020) 1
Genome Biology, 21, 31
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Genome biology, 21 (1), Article: 31
Genome Biology, 21(1). BMC
Genome Biology, 21(1)
Genome Biology, 21, 31. BMC
Genome Biol. 21:31 (2020)
Genome Biology, 21, 1, pp. 31
Genome biology
Lähnemann, D, Köster, J, Szczurek, E, McCarthy, D J, Hicks, S C, Robinson, M D, Vallejos, C A, Campbell, K R, Beerenwinkel, N, Mahfouz, A, Pinello, L, Skums, P, Stamatakis, A, Attolini, C S-O, Aparicio, S, Baaijens, J, Balvert, M, Barbanson, B D, Cappuccio, A, Corleone, G, Dutilh, B E, Florescu, M, Guryev, V, Holmer, R, Jahn, K, Lobo, T J, Keizer, E M, Khatri, I, Kielbasa, S M, Korbel, J O, Kozlov, A M, Kuo, T-H, Lelieveldt, B P F, Mandoiu, I I, Marioni, J C, Marschall, T, Mölder, F, Niknejad, A, Raczkowski, L, Reinders, M, Ridder, J D, Saliba, A-E, Somarakis, A, Stegle, O, Theis, F J, Yang, H, Zelikovsky, A, McHardy, A C, Raphael, B J, Shah, S P & Schönhuth, A 2020, ' Eleven grand challenges in single-cell data science ', Genome Biology, vol. 21, no. 1, pp. 31 . https://doi.org/10.1186/s13059-020-1926-6
Contains fulltext : 218166.pdf (Publisher’s version ) (Open Access) The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands-or even milli
Autor:
Robert E. Beardmore, Martin Ackermann, David Lähnemann, Rafael Peña-Miller, Hinrich Schulenburg
Publikováno v:
Journal of the Royal Society, Interface. 9(75)
Medical and pharmacological communities have long searched for antimicrobial drugs that increase their effect when used in combination, an interaction known as synergism . These drug combinations, however, impose selective pressures in favour of mult
Autor:
Robert E. Beardmore, Martin Ackermann, David Lähnemann, Rafael Peña-Miller, Hinrich Schulenburg
Publikováno v:
Bulletin of mathematical biology. 74(4)
Using optimal control theory as the basic theoretical tool, we investigate the efficacy of different antibiotic treatment protocols in the most exacting of circumstances, described as follows. Viewing a continuous culture device as a proxy for a much