Zobrazeno 1 - 10
of 79
pro vyhledávání: '"David L, Wokosin"'
Autor:
Fanni F. Geibl, Martin T. Henrich, Zhong Xie, Enrico Zampese, Jun Ueda, Tatiana Tkatch, David L. Wokosin, Elena Nasiri, Constantin A. Grotmann, Valina L. Dawson, Ted M. Dawson, Navdeep S. Chandel, Wolfgang H. Oertel, D. James Surmeier
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson’s disease (PD). However, the mechanisms by which intracellular aSYN pathology contributes to dysfunction and degeneration of neurons in
Externí odkaz:
https://doaj.org/article/265447b0a3f045d6bd80bc0702c9544d
Autor:
Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. Wokosin, Patricia González-Rodríguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The corticostriatal dysfunction underlying Huntington’s disease remains incompletely understood. Here, the authors find increased intratelencephalic connectivity resulting from deficient cholinergic transmission in a mouse model of Huntington’s d
Externí odkaz:
https://doaj.org/article/9f3da2a974ae4bf7836154aa87353185
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Methamphetamine (meth) is an addictive psychostimulant and illicit use presents significant personal and socioeconomic harm. Behavioral studies support the involvement of the dorsal striatum in drug-seeking but stimulant induced dysfunction
Externí odkaz:
https://doaj.org/article/9ca35ed49e6949b7930fb72822d81ad2
Autor:
Shingo Ishihara, Alia M. Obeidat, David L. Wokosin, Dongjun Ren, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background C–C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM). Here, we aimed to assess if CCR2 expressed by intra-a
Externí odkaz:
https://doaj.org/article/f167f2cb2b02483c85aff3a5e8fb88a5
Autor:
Yijin Yan, Can Peng, Matthew C. Arvin, Xiao-Tao Jin, Veronica J. Kim, Matthew D. Ramsey, Yong Wang, Sambashiva Banala, David L. Wokosin, J. Michael McIntosh, Luke D. Lavis, Ryan M. Drenan
Publikováno v:
Cell Reports, Vol 23, Iss 8, Pp 2236-2244 (2018)
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown. To study this, we used molecular, physiological, and photostimulation techniques
Externí odkaz:
https://doaj.org/article/a1ac1b7df8814bd78f778dce3b05d25b
Autor:
Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Publikováno v:
eLife, Vol 8 (2019)
Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mech
Externí odkaz:
https://doaj.org/article/6d433a31aa0f4103a04bf72732b8b59c
Autor:
Enrico, Zampese, David L, Wokosin, Patricia, Gonzalez-Rodriguez, Jaime N, Guzman, Tatiana, Tkatch, Jyothisri, Kondapalli, William C, Surmeier, Karis B, D'Alessandro, Diego, De Stefani, Rosario, Rizzuto, Masamitsu, Iino, Jeffery D, Molkentin, Navdeep S, Chandel, Paul T, Schumacker, D James, Surmeier
Publikováno v:
Science advances. 8(39)
How do neurons match generation of adenosine triphosphate by mitochondria to the bioenergetic demands of regenerative activity? Although the subject of speculation, this coupling is still poorly understood, particularly in neurons that are tonically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::585c2e07083b4d0136f56ffe55a7cff7
https://pubmed.ncbi.nlm.nih.gov/36179023
https://pubmed.ncbi.nlm.nih.gov/36179023
Publikováno v:
eLife, Vol 6 (2017)
Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior. It is widely believed that this spiking mode depends upon an interaction between synaptic activat
Externí odkaz:
https://doaj.org/article/4560a5b3996748758ac4985a347bc5db
Autor:
Jeremy F Atherton, Eileen L McIver, Matthew RM Mullen, David L Wokosin, D James Surmeier, Mark D Bevan
Publikováno v:
eLife, Vol 5 (2016)
The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To
Externí odkaz:
https://doaj.org/article/1ce7a2909744475281264f266529e3b2
Publikováno v:
J Neurosci
The debilitating psychomotor symptoms of Huntington's disease (HD) are linked partly to degeneration of the basal ganglia indirect pathway. At early symptomatic stages, before major cell loss, indirect pathway neurons exhibit numerous cellular and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deda6d43d9b1f955b2ca4d93bfa6c269
https://europepmc.org/articles/PMC8916764/
https://europepmc.org/articles/PMC8916764/
