Zobrazeno 1 - 10
of 58
pro vyhledávání: '"David L, Stevens"'
Publikováno v:
Christian Journal for Global Health, Vol 4, Iss 3, Pp 1-15 (2017)
Background: The CMDA/MedSend Healthcare Missions Leadership Summit is an annual gathering of leaders from 75 mission sending agencies who work around the world in healthcare missions. The summit is jointly sponsored by MedSend and the Christian Medic
Externí odkaz:
https://doaj.org/article/72d3c5c417c245b584fed4f2f022117d
Autor:
Boshi Huang, Mengchu Li, Pornprom Klongkumnuankarn, Rolando E. Mendez, James C. Gillespie, David L. Stevens, William L. Dewey, Dana E. Selley, Yan Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:4991-5003
Opioid-induced constipation (OIC) is a common adverse effect of opioid analgesics. Peripherally acting μ opioid receptor antagonists (PAMORAs) can be applied in the treatment of OIC without compromising the analgesic effects. NAP, a 6β-N-4-pyridyl-
Autor:
Piyusha P. Pagare, Mengchu Li, Yi Zheng, Abhishek S. Kulkarni, Samuel Obeng, Boshi Huang, Christian Ruiz, James C. Gillespie, Rolando E. Mendez, David L. Stevens, Justin L. Poklis, Matthew S. Halquist, William L. Dewey, Dana E. Selley, Yan Zhang
Publikováno v:
J Med Chem
The μ opioid receptor (MOR) has been an intrinsic target to develop treatment of opioid use disorders (OUD). Herein, we report our efforts on developing centrally acting MOR antagonists by structural modifications of 17-cyclopropylmethyl-3,14-dihydr
Autor:
Hongguang Ma, Piyusha P. Pagare, Mengchu Li, Logan T. Neel, Rolando E. Mendez, James C. Gillespie, David L. Stevens, William L. Dewey, Dana E. Selley, Yan Zhang
Publikováno v:
Journal of medicinal chemistry.
The search for selective opioid ligands with desired pharmacological potency and improved safety profile has always been an area of interest. Our previous effort yielded a potent opioid modulator, NAN, a 6α
Autor:
Mengchu Li, David L. Stevens, Michelle Arriaga, E. Andrew Townsend, Rolando E. Mendez, Nadejda A. Blajkevch, Dana E. Selley, Matthew L. Banks, S. Stevens Negus, William L. Dewey, Yan Zhang
Publikováno v:
ACS Chem Neurosci
Discovery of analgesics void of abuse liability is critical to battle the opioid crisis in the United States. Among many strategies to achieve this goal, targeting more than one opioid receptor seems promising to minimize this unwanted side effect wh
Autor:
David L. Stevens
Publikováno v:
Christian Journal for Global Health, Vol 2, Iss 1, Pp 3-6 (2015)
Drawing from his experience as a cross-cultural health worker in Africa and his roll in training others for similar missionary service, the author discusses common sources of conflict at a local level inside a larger pressure chamber of political dif
Externí odkaz:
https://doaj.org/article/3de23928eff443f5bb6fda49dd559eb6
Autor:
Neil B. Varshneya, Sherif H. Hassanien, Melissa C. Holt, David L. Stevens, Nathan K. Layle, Jonathon R. Bassman, Donna M. Iula, Patrick M. Beardsley
Publikováno v:
Pharmacology Biochemistry and Behavior. :173572
Autor:
Salvador Sierra, Karan H. Muchhala, Donald K. Jessup, Katherine M. Contreras, Urjita H. Shah, David L. Stevens, Jennifer Jimenez, Xiomara K. Cuno Lavilla, Mario de la Fuente Revenga, Kumiko M. Lippold, Shanwei Shen, Justin L. Poklis, Liya Y. Qiao, William L. Dewey, Hamid I. Akbarali, M. Imad Damaj, Javier González-Maeso
Publikováno v:
Neuropharmacology
Opioids are among the most effective analgesics and the mainstay of pain management. However, concerns about safety and abuse liability have challenged their widespread use by the medical community. Opioid-sparing therapies include drugs that in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95feeb11babd86469a7334f6aa4413de
https://europepmc.org/articles/PMC8934299/
https://europepmc.org/articles/PMC8934299/
Autor:
Neil B, Varshneya, D Matthew, Walentiny, David L, Stevens, Teneille D, Walker, Luli R, Akinfiresoye, Patrick M, Beardsley
Publikováno v:
Pharmacol Biochem Behav
Synthetic narcotics have been implicated as the single greatest contributor to increases in opioid-related fatalities in recent years. This study evaluated the effects of nine fentanyl-related substances that have emerged in the recreational drug mar
Autor:
David L. Stevens, Jeffery Sabina, Jin-Tao Zhang, Kevin Lee, Dieter Söll, Xian Fu, Hui Si Kwok, Yue Shen, Sergey Melnikov, Harry Lee
Publikováno v:
Proc Natl Acad Sci U S A
Antibiotic resistance frequently evolves through fitness trade-offs in which the genetic alterations that confer resistance to a drug can also cause growth defects in resistant cells. Here, through experimental evolution in a microfluidics-based turb