Zobrazeno 1 - 10
of 131
pro vyhledávání: '"David L, Sacks"'
Autor:
Hermali Silva, Tiago R. Ferreira, Kajan Muneeswaran, Sumudu R. Samarasinghe, Eliza V.C. Alves-Ferreira, Michael E. Grigg, Naduviladath V. Chandrasekharan, David L. Sacks, Nadira D. Karunaweera
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 9, Pp 1872-1883 (2024)
Cutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L. donovani and other Leishmania spp. usually responsible
Externí odkaz:
https://doaj.org/article/b7cf2eb01d60490dbf5eba817945b4b6
Autor:
Sang Hun Lee, Byunghyun Kang, Olena Kamenyeva, Tiago Rodrigues Ferreira, Kyoungin Cho, Jaspal S. Khillan, Juraj Kabat, Brian L. Kelsall, David L. Sacks
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Tissue-resident macrophages are critical for tissue homeostasis and repair. We previously showed that dermis-resident macrophages produce CCL24 which mediates their interaction with IL-4+ eosinophils, required to maintain their M2-like prope
Externí odkaz:
https://doaj.org/article/9b9bb96b2d714cf39e936ddda5e4e07b
Autor:
Tiago R. Ferreira, David L. Sacks
Publikováno v:
Pathogens, Vol 11, Iss 5, p 580 (2022)
Despite major advances over the last decade in our understanding of Leishmania reproductive strategies, the sexual cycle in Leishmania has defied direct observation and remains poorly investigated due to experimental constraints. Here, we summarize t
Externí odkaz:
https://doaj.org/article/a9b2a837ab89450d854974b4388713eb
Autor:
Juliana Alcoforado Diniz, Mariana M Chaves, Slavica Vaselek, Rubens D Miserani Magalhães, Rafael Ricci-Azevedo, Renan V H de Carvalho, Lucas B Lorenzon, Tiago R Ferreira, Dario Zamboni, Pegine B Walrad, Petr Volf, David L Sacks, Angela K Cruz
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009230 (2021)
Leishmania major is the main causative agent of cutaneous leishmaniasis in the Old World. In Leishmania parasites, the lack of transcriptional control is mostly compensated by post-transcriptional mechanisms. Methylation of arginine is a conserved po
Externí odkaz:
https://doaj.org/article/fc6c456a480446dd8f8cc9b8f8b6c3d8
Autor:
Michael D Lewis, Andrea Paun, Audrey Romano, Harry Langston, Charlotte A Langner, Ian N Moore, Kevin W Bock, Amanda Fortes Francisco, Jason M Brenchley, David L Sacks
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008456 (2020)
Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment sequelae, sp
Externí odkaz:
https://doaj.org/article/af5cfafb500f43f2863c96529f116712
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Sand flies are the natural vectors for the Leishmania species that produce a spectrum of diseases in their mammalian hosts, including humans. Studies of sand fly/Leishmania interactions have been limited by the absence of genome editing tech
Externí odkaz:
https://doaj.org/article/33eb51800b104e918f96c02481bb267c
Publikováno v:
Genes, Vol 12, Iss 2, p 167 (2021)
A cryptic sexual reproductive cycle in Leishmania has been inferred through population genetic studies revealing the presence of hybrid genotypes in natural isolates, with attempts made to decipher sexual strategies by studying complex chromosomal in
Externí odkaz:
https://doaj.org/article/5a03cd15a7404e0bbf798a188b6dd33c
Autor:
Stefano A. Iantorno, Caroline Durrant, Asis Khan, Mandy J. Sanders, Stephen M. Beverley, Wesley C. Warren, Matthew Berriman, David L. Sacks, James A. Cotton, Michael E. Grigg
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and
Externí odkaz:
https://doaj.org/article/3b56349811ae4170ad5d58be0a235158
Autor:
Audrey Romano, Matheus B H Carneiro, Nicole A Doria, Eric H Roma, Flavia L Ribeiro-Gomes, Ehud Inbar, Sang Hun Lee, Jonatan Mendez, Andrea Paun, David L Sacks, Nathan C Peters
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006479 (2017)
Inflammatory monocytes can be manipulated by environmental cues to perform multiple functions. To define the role of monocytes during primary or secondary infection with an intra-phagosomal pathogen we employed Leishmania major-red fluorescent protei
Externí odkaz:
https://doaj.org/article/719e457dc0f44cb48b46e5d060e60811
Autor:
Ehud Inbar, V. Keith Hughitt, Laura A. L. Dillon, Kashinath Ghosh, Najib M. El-Sayed, David L. Sacks
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT The life cycle of the Leishmania parasite in the sand fly vector involves differentiation into several distinctive forms, each thought to represent an adaptation to specific microenvironments in the midgut of the fly. Based on transcriptome
Externí odkaz:
https://doaj.org/article/0237bcd8c10b4444ae0c597be089eebf