Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David L'Hôte"'
Autor:
Charles Le Ciclé, Vincent Pacini, Nicolas Rama, Servane Tauszig-Delamasure, Eloïse Airaud, Florence Petit, Simon de Beco, Joëlle Cohen-Tannoudji, David L’hôte
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-17 (2023)
Abstract Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in vertebrates. These cells emerge early during embryogenesis, colonize the pituitary glands and organize in tridimensional networks, which are believed t
Externí odkaz:
https://doaj.org/article/51b074886c5a4ab48bb879105a32b844
Autor:
Ghislaine Garrel, Claude Rouch, David L’Hôte, Salma Tazi, Nadim Kassis, Frank Giton, Julien Dairou, Pascal Dournaud, Pierre Gressens, Christophe Magnan, Céline Cruciani-Guglielmacci, Joëlle Cohen-Tannoudji
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Overnutrition is associated with the activation of inflammatory pathways in metabolically linked organs and an early hypothalamic inflammation is now known to disrupt the central control of metabolic function. Because we demonstrated that fatty acids
Externí odkaz:
https://doaj.org/article/13fcbbcbc2394ccca03c88ae775e2190
Autor:
Charlotte Avet, Emmanuel N. Paul, Ghislaine Garrel, Valérie Grange-Messent, David L’Hôte, Chantal Denoyelle, Raphaël Corre, Jean-Marie Dupret, Sophie Lanone, Jorge Boczkowski, Violaine Simon, Joëlle Cohen-Tannoudji
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Toxic effects of nanoparticles on female reproductive health have been documented but the underlying mechanisms still need to be clarified. Here, we investigated the effect of carbon black nanoparticles (CB NPs) on the pituitary gonadotropins, lutein
Externí odkaz:
https://doaj.org/article/21e32b2587d044d4ad225e98541449c0
Autor:
Vincent Pacini, Florence Petit, Bruno Querat, Jean-Noël Laverriere, Joëlle Cohen-Tannoudji, David L’hôte
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract Background Gonadotrope lineage differentiation is a stepwise process taking place during pituitary development. The early step of gonadotrope lineage specification is characterized by the expression of the Nr5a1 transcription factor, a cruci
Externí odkaz:
https://doaj.org/article/c5ada0a875454d29b64e28c9018a3000
Autor:
Charlotte Avet, Chantal Denoyelle, David L'Hôte, Florence Petit, Céline J Guigon, Joëlle Cohen-Tannoudji, Violaine Simon
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201494 (2018)
Reproductive function is under the control of the neurohormone GnRH, which activates a G-protein-coupled receptor (GnRHR) expressed in pituitary gonadotrope cells. GnRHR activates a complex signaling network to regulate synthesis and secretion of the
Externí odkaz:
https://doaj.org/article/46afed9c6b2b4304835cba11b7afbfe2
Autor:
Adrien Georges, David L'Hôte, Anne Laure Todeschini, Aurélie Auguste, Bérangère Legois, Alain Zider, Reiner A Veitia
Publikováno v:
eLife, Vol 3 (2014)
FOXL2 is a lineage determining transcription factor in the ovary, but its direct targets and modes of action are not fully characterized. In this study, we explore the targets of FOXL2 and five nuclear receptors in murine primary follicular cells. We
Externí odkaz:
https://doaj.org/article/dd45f11294ee49e2a492f9ff1cab2512
Autor:
Mikko Anttonen, Marjut Pihlajoki, Noora Andersson, Adrien Georges, David L'hôte, Sanna Vattulainen, Anniina Färkkilä, Leila Unkila-Kallio, Reiner A Veitia, Markku Heikinheimo
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85545 (2014)
Aberrant ovarian granulosa cell proliferation and apoptosis may lead to granulosa cell tumors (GCT), the pathogenesis of which involves transcription factors GATA4, FOXL2, and SMAD3. FOXL2 gene harbors a point mutation (C134W) in a vast majority of G
Externí odkaz:
https://doaj.org/article/94e0c06cb7f5423a9c8c35a81bd5320b
Autor:
Adrien Georges, Bérénice A Benayoun, Mara Marongiu, Aurélie Dipietromaria, David L'Hôte, Anne-Laure Todeschini, Jana Auer, Laura Crisponi, Reiner A Veitia
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25463 (2011)
BACKGROUND: FOXL2 is a transcription factor essential for ovarian development and maintenance. It is mutated in the genetic condition called Blepharophimosis Ptosis Epicantus inversus Syndrome (BPES) and in cases of isolated premature ovarian failure
Externí odkaz:
https://doaj.org/article/1b3eb1220c2e47c3aba4b5db7819ae43
Autor:
David L'Hôte, Magalie Vatin, Jana Auer, Johan Castille, Bruno Passet, Xavier Montagutelli, Catherine Serres, Daniel Vaiman
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27582 (2011)
BACKGROUND: In a previous work, using an interspecific recombinant congenic mouse model, we reported a genomic region of 23 Mb on mouse chromosome 11 implicated in testis weight decrease and moderate teratozoospermia (∼20-30%), a Quantitative Trait
Externí odkaz:
https://doaj.org/article/2de1d5bac2b04f2fb0343110c9fe1a14
Autor:
Bérénice A Benayoun, Sandrine Caburet, Aurélie Dipietromaria, Adrien Georges, Barbara D'Haene, P J Eswari Pandaranayaka, David L'Hôte, Anne-Laure Todeschini, Sankaran Krishnaswamy, Marc Fellous, Elfride De Baere, Reiner A Veitia
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8789 (2010)
BackgroundThe somatic mutation in the FOXL2 gene c.402C>G (p.Cys134Trp) has recently been identified in the vast majority of adult ovarian granulosa cell tumors (OGCTs) studied. In addition, this mutation seems to be specific to adult OGCTs and is li
Externí odkaz:
https://doaj.org/article/a9ad7ce6b18146d99665cfccbcd63a62