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Akademický článek

Expert consensus on the management of pharmacodynamic breakthrough-hemolysis in treated paroxysmal nocturnal hemoglobinuria

Autor: David Dingli, Carlos De Castro III, Jamie Koprivnikar, Austin Kulasekararaj, Jaroslaw Maciejewski, Brian Mulherin, Jens Panse, Vinod Pullarkat, Alexander Röth, Jamile Shammo, Louis Terriou, Ilene Weitz, Irina Yermilov, Sarah Gibbs, Michael Broder, David Beenhouwer, David Kuter

Publikováno v: Hematology, Vol 29, Iss 1 (2024)

ABSTRACTIntroduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, non-malignant hematologic disease characterized by complement-mediated hemolysis (with or without hemoglobinuria), fatigue, increased susceptibility to thrombosis, a

Externí odkaz: https://doaj.org/article/9910639b99bf41af8dfaccc4685e89c0

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Akademický článek

Gut Microbiota and Coronary Plaque Characteristics

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 17 (2022)

Background The relationship between gut microbiota and in vivo coronary plaque characteristics has not been reported. This study was conducted to investigate the relationship between gut microbiota and coronary plaque characteristics in patients with

Externí odkaz: https://doaj.org/article/631605d8db3e48e39e1e4e2fabdeb78f

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Akademický článek

An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules

Autor: Aiten Ismailova, David Kuter, D. Scott Bohle, Ian S. Butler

Publikováno v: Bioinorganic Chemistry and Applications, Vol 2018 (2018)

Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Sinc

Externí odkaz: https://doaj.org/article/117182ce09a4484cb7e32b4f5dc2ec63

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Akademický článek

Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.

Autor: Juliana B R Corrêa Soares, Diego Menezes, Marcos A Vannier-Santos, Antonio Ferreira-Pereira, Giulliana T Almeida, Thiago M Venancio, Sergio Verjovski-Almeida, Vincent K Zishiri, David Kuter, Roger Hunter, Timothy J Egan, Marcus F Oliveira

Publikováno v: PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e477 (2009)

BACKGROUND: The parasitic trematode Schistosoma mansoni is one of the major causative agents of human schistosomiasis, which afflicts 200 million people worldwide. Praziquantel remains the main drug used for schistosomiasis treatment, and reliance on

Externí odkaz: https://doaj.org/article/62d139d5534641b28986c39ac7bf0dac

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