Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David Kunke"'
Autor:
Thomas Payne, Jennifer Taylor, David Kunkel, Katherine Konieczka, Frankie Ingram, Kaj Blennow, Henrik Zetterberg, Robert A. Pearce, Anke Meyer-Franke, Niccolò Terrando, Katerina Akassoglou, Robert D. Sanders, Richard C. Lennertz
Publikováno v:
BJA Open, Vol 12, Iss , Pp 100349- (2024)
Background: We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood–brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.
Externí odkaz:
https://doaj.org/article/46f97a63a6754a3c850420900105059e
Autor:
Gunn A. Hildrestrand, Nils Bolstad, Luisa Luna, David Kunke, Dzung B. Diep, Stefan Krauss, Magnar Bjørås
Publikováno v:
DNA Repair. 6:723-732
In mammalian cells, 8-oxoguanine DNA glycosylase-1 (OGG1) is the main DNA glycosylase for the removal of 8-oxoguanine (8-oxoG). 8-oxoG, one of the most common products of the oxidative attack of DNA, is a premutagenic lesion that accumulates spontane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57077496d40d67855a19ed8720194f15
https://doi.org/10.1016/j.dnarep.2006.12.008
https://doi.org/10.1016/j.dnarep.2006.12.008
Autor:
Daniel Bratbak, Christopher Baum, Aurelio Lorico, Stefan Krauss, Johann Meyer, Victor Solodushko, Germana Rappa, David Kunke, Øystein Fodstad, Walter E. Plott
Publikováno v:
Human Gene Therapy. 16:711-724
In most experimental gene therapy protocols involving stem/progenitor cells, only a small fraction of cells, often therapeutically inadequate, can be transduced and made to express the therapeutic gene. A promising strategy for overcoming this proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca21ff0fbd01cd4aea108fcd2fd1a0b
https://doi.org/10.1089/hum.2005.16.711
https://doi.org/10.1089/hum.2005.16.711
Autor:
Luisa Luna, Gunn A. Hildrestrand, Yngve Sejersted, Rajikala Suganthan, Christine G. Neurauter, Magnar Bjørås, Silje Zandstra Krokeide, David Kunke, Veslemøy Rolseth
Publikováno v:
Biochimica et biophysica acta. 1833(5)
7,8-Dihydro-8-oxoguanine (8-oxoG) is one of the most common oxidative base lesions in normal tissues induced by a variety of endogenous and exogenous agents. Hydantoins are products of 8-oxoG oxidation and as 8-oxoG, they have been shown to be mutage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e741f9414c32888f1c3da5540e2371
https://pubmed.ncbi.nlm.nih.gov/23305905
https://pubmed.ncbi.nlm.nih.gov/23305905
Autor:
Håvard Attramadal, Signe Flood Kjeldsen, David Kunke, Johanna Samulin Erdem, Ansgar O. Aasen, Yun Yong Wang, Shakil M Ahmed, Claus Vinter Bødker Hviid
Publikováno v:
Innate immunity. 18(5)
Organ failure is a severe complication in sepsis for which the pathophysiology remains incompletely understood. Recently, the matri-cellular cysteine-rich, angiogenic induced, 61 ( Cyr61/CCN1); connective tissue growth factor ( Ctgf/CCN2); and nephro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7d8006de94991e2dd9a033b473f9b7
https://pubmed.ncbi.nlm.nih.gov/22334618
https://pubmed.ncbi.nlm.nih.gov/22334618
Autor:
Veslemøy Rolseth, Cynthia J. Burrows, Rajikala Suganthan, David Kunke, Ola Didrik Saugstad, Gunn A. Hildrestrand, Christine G. Neurauter, Aaron M. Fleming, Luisa Luna, Yngve Sejersted, Monica Atneosen-Åsegg, Silje Zandstra Krokeide, Magnar Bjørås
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(46)
Neural stem/progenitor cell proliferation and differentiation are required to replace damaged neurons and regain brain function after hypoxic-ischemic events. DNA base lesions accumulating during hypoxic-ischemic stress are removed by DNA glycosylase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d201fc4c8f8c674ea4e0d2fc215214
https://pubmed.ncbi.nlm.nih.gov/22065741
https://pubmed.ncbi.nlm.nih.gov/22065741
Autor:
Ying Esbensen, Wei Wang, Magnar Bjørås, Lyudmila I. Rachek, David Kunke, Lars Eide, Rajikala Suganthan
The mitochondrial DNA (mtDNA) of neural stem cells (NSCs) is vulnerable to oxidation damage. Subtle manipulations of the cellular redox state affect mtDNA integrity in addition to regulating the NSC differentiation lineage, suggesting a molecular lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a5e6c7eeb7a91c0ab11c03d435cd4b
https://europepmc.org/articles/PMC6623160/
https://europepmc.org/articles/PMC6623160/
Autor:
David Kunkel, Margaret Parker, Cameron Casey, Bryan Krause, Jennifer Taylor, Robert A. Pearce, Richard Lennertz, Robert D. Sanders
Publikováno v:
BJA Open, Vol 2, Iss , Pp 100006- (2022)
Background: Perioperative inflammation is associated with perioperative complications, including delirium, that are associated with a reduced number of postoperative days alive and at home at 90 days (DAH90). We tested whether inflammation was associ
Externí odkaz:
https://doaj.org/article/49c4e74195864577ae5b73a79117fc6d
Publikováno v:
Biochemical and biophysical research communications. 386(4)
Wnt signaling plays an essential role in the development of mammalian central nervous system. We investigated the impact of activation/inhibition of the Wnt signaling pathway on neuronal/glial differentiation in neurospheres derived from neonatal mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e37411e240a87933509667f365edc46
https://pubmed.ncbi.nlm.nih.gov/19545542
https://pubmed.ncbi.nlm.nih.gov/19545542
Autor:
Dirk Grimm, Hajo Delius, Jürgen A. Kleinschmidt, Dymitr Komitowski, S. Denger, David Kunke, Jörg Kreuzer
Publikováno v:
Cancer gene therapy. 7(5)
Approximately 90% of cervical carcinomas are causally linked to infections with high-risk human papillomaviruses (HPVs), whose oncogenicity has been assigned to the continued expression of two early genes, E6 and E7. Reversal of the transformed pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1e6d97059a22763b5685b5a3825f9d
https://pubmed.ncbi.nlm.nih.gov/10830724
https://pubmed.ncbi.nlm.nih.gov/10830724