Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David Krull"'
Autor:
Yongfeng Chen, Wei Zhen, Tony Guo, Yonggang Zhao, Ailian Liu, Justin P Rubio, David Krull, Jill C Richardson, Hongtao Lu, Ryan Wang
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189380 (2017)
Agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed remyelination in patients with multiple sclerosis. However, few therapeutic targets have been identified. The objective of this study
Externí odkaz:
https://doaj.org/article/90cda7d5da394f42a77356dbbee8e3a5
Autor:
Elizabeth A Chlipala, Traci DeGeer, Kathleen Dwyer, Shelley Ganske, David Krull, Haydee Lara, Lisa Manning, Dylan Steiner, Lisa Stephens, Diane Sterchi, Aubrey Wanner, Connie Wildeman, Liron Pantanowitz
Publikováno v:
Journal of Pathology Informatics, Vol 10, Iss 1, Pp 14-14 (2019)
The field of digital pathology has rapidly expanded within the last few years with increasing adoption and growth in popularity. As digital pathology matures, it is apparent that we need well-trained individuals to manage our whole-slide imaging syst
Externí odkaz:
https://doaj.org/article/a8ab5c34e27b4826bb5adc706c3c08f9
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117355 (2015)
Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal neurodegenerative disease with a high unmet medical need. In this context, a potential therapy should be brought to patients in the most expeditious way and early exploration of pharmacology is
Externí odkaz:
https://doaj.org/article/ecd3addcfebe4537981d48fc83135822
Autor:
Vincent Meininger, Pierre-François Pradat, Andrea Corse, Safa Al-Sarraj, Benjamin Rix Brooks, James B Caress, Merit Cudkowicz, Stephen J Kolb, Dale Lange, P Nigel Leigh, Thomas Meyer, Stefano Milleri, Karen E Morrison, Richard W Orrell, Gary Peters, Jeffrey D Rothstein, Jeremy Shefner, Arseniy Lavrov, Nicola Williams, Phil Overend, Jeffrey Price, Stewart Bates, Jonathan Bullman, David Krull, Alienor Berges, Bams Abila, Guy Meno-Tetang, Jens Wurthner
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97803 (2014)
The neurite outgrowth inhibitor, Nogo-A, has been shown to be overexpressed in skeletal muscle in amyotrophic lateral sclerosis (ALS); it is both a potential biomarker and therapeutic target. We performed a double-blind, two-part, dose-escalation stu
Externí odkaz:
https://doaj.org/article/a10f2b867b174c858f2c458ef8e54388
Autor:
Leslie Abad, Maxine McClain, Edward Bonnevie, Benjamin Chen, Sarah Church, Gokhan Demirkan, Premi Haynes, Kelly Hunter, Anil Kersarwani, David Krull, Yan Liang, Prithwish Pal, Corinne Ramos, Deniliz Rodriguez, Jessica Runyon, Julien Tessier, Esperanza Anguiano
Publikováno v:
Cancer Research. 83:986-986
The interest and utility of high-plex spatial profiling of RNA and protein biomarkers has increased over the last few years. The implementation of high-plex analyte spatial platforms, such as GeoMx® Digital Spatial Profiler (DSP), is increasing with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c39885f71265f07f663bb643bbaaf871
https://doi.org/10.1158/1538-7445.am2023-986
https://doi.org/10.1158/1538-7445.am2023-986
Autor:
David Krull, Ryan Wang, Jill C. Richardson, Yongfeng Chen, Ailian Liu, Tony Guo, Wei Zhen, Yonggang Zhao, Justin P. Rubio, Hongtao Lu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189380 (2017)
PLoS ONE, Vol 12, Iss 12, p e0189380 (2017)
Background Agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed remyelination in patients with multiple sclerosis. However, few therapeutic targets have been identified. The objective of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f4af27784f56caca55d813bede2369
http://europepmc.org/articles/PMC5734789
http://europepmc.org/articles/PMC5734789
Autor:
Mi Xie, David Krull, John Johnson, Richard A. Peterson, Yoshio Morikawa, Jessica Vamathevan, Elizabeth Thomas, Derek J. Parks, Amanda Mathis, Stephanie Van Horn, Michael Thomson, Robert Hamatake, Joseph Horton, Jeffrey J. Pouliot, Takashi Shimada, Zhiping Xiong, Andrew J. Peat
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:6539-6550
The hepatitis C virus (HCV) NS4B protein is an antiviral therapeutic target for which small-molecule inhibitors have not been shown to exhibit in vivo efficacy. We describe here the in vitro and in vivo antiviral activity of GSK8853, an imidazo[1,2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ea895720909938b116b0b620817c2e
https://doi.org/10.1128/aac.00813-15
https://doi.org/10.1128/aac.00813-15
Autor:
Alexander P. Nesmith, Megan L. McCain, Robert N. Willette, Pu Qin, Sean P. Sheehy, David J. Behm, Mackenzie A. Eagleson, Anna Grosberg, Kevin Kit Parker, John P. Ferrier, James G Falls, David Krull, Patrick H. Campbell, Erding Hu
Publikováno v:
Sheehy, SP; Grosberg, A; Qin, P; Behm, DJ; Ferrier, JP; Eagleson, MA; et al.(2017). Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. EXPERIMENTAL BIOLOGY AND MEDICINE, 242(17), 1643-1656. doi: 10.1177/1535370217701006. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/81v8p0s0
In vitro studies of cardiac physiology and drug response have traditionally been performed on individual isolated cardiomyocytes or isotropic monolayers of cells that may not mimic desired physiological traits of the laminar adult myocardium. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942b96934c1ec656f3d0b066ab945a9b
http://www.escholarship.org/uc/item/81v8p0s0
http://www.escholarship.org/uc/item/81v8p0s0
Autor:
Linda Greensmith, James R. Dick, Virginie Bros-Facer, Matthew Cleveland, David Krull, Adam Taylor, Rab K. Prinjha, Stewart Bates
Publikováno v:
Human Molecular Genetics. 23:4187-4200
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disorder in which motor neurons in the spinal cord and motor cortex degenerate. Although the majority of ALS cases are sporadic, mutations in Cu-Zn superoxide dismutase-1 (SOD1) are ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e08610ecd52326af2c50337fa2082e
https://doi.org/10.1093/hmg/ddu136
https://doi.org/10.1093/hmg/ddu136
Autor:
Kathleen Dwyer, Liron Pantanowitz, Dylan Steiner, Aubrey M J Wanner, Traci DeGeer, Connie I Wildeman, David Krull, Diane Sterchi, Haydee Lara, Shelley Ganske, Lisa Manning, Lisa Stephens, Elizabeth A Chlipala
Publikováno v:
Journal of Pathology Informatics, Vol 10, Iss 1, Pp 14-14 (2019)
The field of digital pathology has rapidly expanded within the last few years with increasing adoption and growth in popularity. As digital pathology matures, it is apparent that we need well-trained individuals to manage our whole-slide imaging syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd5e209d1509526b10acfdbba736dc9
https://doi.org/10.4103/jpi.jpi_5_19
https://doi.org/10.4103/jpi.jpi_5_19