Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David Kosoff"'
Autor:
Erika Heninger, Matthew Thomas Breneman, Emma Elizabeth Recchia, Sheena Catherine Kerr, Reyna Elvan Dogru, Marina Nasrin Sharifi, Aaron Matthew LeBeau, David Kosoff
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Tumor-associated macrophages (TAMs) have been implicated as a tumor microenvironment (TME) cell population, which may be playing a vital role in the inhibition of effective T cell responses in the prostate TME. In this manuscript, we leverag
Externí odkaz:
https://doaj.org/article/4aa1d1c3b3f343399d371dbd6149337f
Autor:
Nicholas R. Rydzewski, Yue Shi, Chenxuan Li, Matthew R. Chrostek, Hamza Bakhtiar, Kyle T. Helzer, Matthew L. Bootsma, Tracy J. Berg, Paul M. Harari, John M. Floberg, Grace C. Blitzer, David Kosoff, Amy K. Taylor, Marina N. Sharifi, Menggang Yu, Joshua M. Lang, Krishnan R. Patel, Deborah E. Citrin, Kaitlin E. Sundling, Shuang G. Zhao
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independent
Externí odkaz:
https://doaj.org/article/27df8447126a4b8db5d9d92bb0d0f133
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Poly-ADP ribose polymerase inhibitors (PARPi) are an emerging therapeutic option for the treatment of prostate cancer. Their primary mechanism of action is via induction of synthetic lethality in cells with underlying deficiencies in homologous recom
Externí odkaz:
https://doaj.org/article/ec1039754dd548bf89168a435ead7aa0
Autor:
Shuang G. Zhao, Jamie M. Sperger, Jennifer L. Schehr, Rana R. McKay, Hamid Emamekhoo, Anupama Singh, Zachery D. Schultz, Rory M. Bade, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Camila I. Hernandez, Serena K. Wolfe, Richel D. Mayberry, Hannah M. Krause, Matt Bootsma, Kyle T. Helzer, Nicholas Rydzewski, Hamza Bakhtiar, Yue Shi, Grace Blitzer, Christos E. Kyriakopoulos, David Kosoff, Xiao X. Wei, John Floberg, Nan Sethakorn, Marina Sharifi, Paul M. Harari, Wei Huang, Himisha Beltran, Toni K. Choueiri, Howard I. Scher, Dana E. Rathkopf, Susan Halabi, Andrew J. Armstrong, David J. Beebe, Menggang Yu, Kaitlin E. Sundling, Mary-Ellen Taplin, Joshua M. Lang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Background Neuroendocrine prostate cancer (NEPC) is an aggressive subtype, the presence of which changes the prognosis and management of metastatic prostate cancer.Methods We performed analytical validation of a Circulating Tumor Cell (CTC) multiplex
Externí odkaz:
https://doaj.org/article/ec5e2f5145314e94b0c25808c0d5eee0
Autor:
Matthew Bootsma, Rana R. McKay, Hamid Emamekhoo, Rory M. Bade, Jennifer L. Schehr, Matthew C. Mannino, Anupama Singh, Serena K. Wolfe, Zachery D. Schultz, Jamie Sperger, Wanling Xie, Sabina Signoretti, Christos E. Kyriakopoulos, David Kosoff, Edwin J. Abel, Kyle T. Helzer, Nicholas Rydzewski, Hamza Bakhtiar, Yue Shi, Grace Blitzer, Michael Bassetti, John Floberg, Menggang Yu, Nan Sethakorn, Marina Sharifi, Paul M. Harari, Toni K. Choueiri, Joshua M. Lang, Shuang G. Zhao
Publikováno v:
Journal of Clinical Oncology. 40:3633-3641
PURPOSE Liquid biopsies in metastatic renal cell carcinoma (mRCC) provide a unique approach to understand the molecular basis of treatment response and resistance. This is particularly important in the context of immunotherapies, which target key imm
Autor:
Grigor Simitian, María Virumbrales-Muñoz, Cristina Sánchez-de-Diego, David J. Beebe, David Kosoff
Publikováno v:
Lab on a Chip. 22:3618-3636
Here we provide a detailed review of the use of microfluidic technologies in vascular biology. This review focuses on how to recapitulate and investigate biological hallmarks and is written for a wide audience ranging from clinicians to engineers.
Autor:
Nan Sethakorn, Erika Heninger, Matthew T. Breneman, Emma Recchia, Adeline B. Ding, David F. Jarrard, Peiman Hematti, David J. Beebe, David Kosoff
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(10)
The tumor microenvironment (TME) is a complex network of non-malignant cells and stroma that perform a wide array of vital roles in tumor growth, immune evasion, metastasis, and therapeutic resistance. These highly diverse roles have been shown to be
Autor:
Erika Heninger, Morgan D. Kuczler, Nan Sethakorn, David Kosoff, Joshua M. Lang, Kenneth J. Pienta, Peiman Hematti
Publikováno v:
Oncotarget
Bone marrow (BM) is a primary metastatic site in prostate cancer (PC) and bone invasion is considered incurable. T cell-mediated immune surveillance is essential in controlling both tumorigenesis and initiation of metastases. Beside tropism, dissemin
Autor:
Bing Yang, Erika Heninger, Leigh Ellis, David Kosoff, David J. Beebe, Kristin N. Carlson, Dustin A. Deming, Joshua M. Lang, Harshitha Gungurthi, Tamara S. Rodems, Anupama Singh, Nan Sethakorn, Cole Gilsdorf, Cheri A. Pasch, David F. Jarrard
Publikováno v:
Medical Oncology (Northwood, London, England)
Prostate Cancer (PC) is a disease with remarkable tumor heterogeneity that often manifests in significant intra-patient variability with regards to clinical outcomes and treatment response. Commonly available PC cell lines do not accurately reflect t
Autor:
David Kosoff, Joshua M. Lang
Publikováno v:
Urol Oncol
Tumor-associated macrophages (TAMs) regulate an array of tumor functions and have critical roles in both the progression as well as the eradication of cancer. Numerous therapies targeting TAMs are under development in cancer and many have demonstrate