Zobrazeno 1 - 10
of 41
pro vyhledávání: '"David Klatzman"'
Autor:
Pierre Ellul, Anna Maruani, Hugo Peyre, Valérie Vantalon, Daphnée Hoareau, Hugo Tiercelin, Michelle Rosenzwajg, David Klatzmann, Richard Delorme
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract Maternal immune activation (MIA), related to autoimmune/inflammatory diseases or acute infections, during the two first trimesters of pregnancy is a risk factor for autism spectrum disorders (ASD) in offspring. In mice, MIA has a long-term i
Externí odkaz:
https://doaj.org/article/721b3894824a4261a61bb986bb6c4686
Autor:
Aude Belbezier, Paul Engeroff, Gwladys Fourcade, Hélène Vantomme, Romain Vaineau, Bruno Gouritin, Bertrand Bellier, Isabelle Brocheriou, Nicolas Tchitchek, Stephanie Graff-Dubois, David Klatzmann
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAntibody production and the generation of memory B cells are regulated by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in germinal centers. However, the precise role of Tfr cells in controlling antibody production is
Externí odkaz:
https://doaj.org/article/1970145b093f439fac4b1076c56464d0
Autor:
Michelle Rosenzwajg, Roberta Lorenzon, Patrice Cacoub, Arsène Mekinian, Anne Daguenel-Nguyen, Eric Vicaut, David Klatzmann, Sébastien Rivière, Olivier Fain, François Barde, Carlotta Cacciatore
Publikováno v:
RMD Open, Vol 10, Iss 2 (2024)
Background Systemic sclerosis (SSc) is a chronic autoimmune disease, with impaired immune response, increased fibrosis and endothelial dysfunction. Regulatory T cells (Tregs), which are essential to control inflammation, tissue repair and autoimmunit
Externí odkaz:
https://doaj.org/article/e5b137d132bf459ca9fb96fbef61239a
Autor:
Pierre Ellul, Anna Maruani, Valérie Vantalon, Elise Humeau, Anouck Amestoy, Andrea Anchordoqui, Paola Atzori, Jean-Marc Baleyte, Safiyah Benmansour, Olivier Bonnot, Manuel Bouvard, Ariane Cartigny, Nathalie Coulon, Romain Coutelle, David Da Fonseca, Caroline Demily, Marion Givaudan, Fanny Gollier-Briant, Fabian Guénolé, Andrea Koch, Marion Leboyer, Aline Lefebvre, Florian Lejuste, Charlotte Levy, Eugénie Mendes, Natalia Robert, Carmen M. Schroder, Mario Speranza, Elodie Zante, Hugo Peyre, Michelle Rosenzwajg, David Klatzmann, Nicolas Tchitchek, Richard Delorme
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Autism spectrum disorder (ASD) are neurodevelopmental conditions characterised by deficits in social communication and interaction and repetitive behaviours. Maternal immune activation (MIA) during the mid-pregnancy is a known risk factor fo
Externí odkaz:
https://doaj.org/article/69be2d49d6274fadb9fccaad12471aba
Autor:
Valentin Quiniou, Pierre Barennes, Vanessa Mhanna, Paul Stys, Helene Vantomme, Zhicheng Zhou, Federica Martina, Nicolas Coatnoan, Michele Barbie, Hang-Phuong Pham, Béatrice Clémenceau, Henri Vie, Mikhail Shugay, Adrien Six, Barbara Brandao, Roberto Mallone, Encarnita Mariotti-Ferrandiz, David Klatzmann
Publikováno v:
eLife, Vol 12 (2023)
T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >1019 sequences. They are selected during thymopoiesis, which releases a repertoire of about 108 unique TCRs per individual. How evolution shaped a process
Externí odkaz:
https://doaj.org/article/c330db7a9f61475c8f6b69524299a6bc
Autor:
Pierre Ellul, Eric Acquaviva, Hugo Peyre, Michelle Rosenzwajg, Pierre Gressens, David Klatzmann, Richard Delorme
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Epidemiological studies have raised concerns about the risk of neurodevelopmental disorders (NDD) in children of patients with autoimmune or inflammatory disorders (AID). The pathophysiological pathways underlying this association are still
Externí odkaz:
https://doaj.org/article/423ed6b29f0b4c54bad54f7ce4c382b5
Autor:
Nicolas Tchitchek, Otriv Nguekap Tchoumba, Gabriel Pires, Sarah Dandou, Julien Campagne, Guillaume Churlaud, Gwladys Fourcade, Thomas W. Hoffmann, Francesco Strozzi, Camille Gaal, Christophe Bonny, Emmanuelle Le Chatelier, Stanislav Dusko Erlich, Harry Sokol, David Klatzmann
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Gut microbiota dysbiosis is associated with inflammatory bowel diseases and with cardiometabolic, neurological, and autoimmune diseases. Gut microbiota composition has a direct effect on the immune system, and vice versa, and it has a particular effe
Externí odkaz:
https://doaj.org/article/2df5a711b6a24aac80b656c34dcd1f2b
Autor:
Francis Berenbaum, Jérémie Sellam, David Klatzmann, Atul J Butte, Karine Louati, Encarnita Mariotti-Ferrandiz, Marie Binvignat, Valentina Pedoia
Publikováno v:
RMD Open, Vol 8, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/4901092a9fb640168e0fe7bf31e8a7dd
Autor:
Berglind Bergmann, Ying Fei, Pernilla Jirholt, Zhicheng Hu, Maria Bergquist, Abukar Ali, Catharina Lindholm, Olov Ekwall, Guillaume Churlaud, David Klatzmann, Tao Jin, Inger Gjertsson
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Staphylococcus aureus (S. aureus) arthritis is one of the most detrimental joint diseases known and leads to severe joint destruction within days. We hypothesized that the provision of auxiliary immunoregulation via an expanded co
Externí odkaz:
https://doaj.org/article/e37e69b8fcc745dfa3d8d446c3678010
Autor:
Akpéli V. Nordor, Djamel Nehar-Belaid, Sophie Richon, David Klatzmann, Dominique Bellet, Virginie Dangles-Marie, Thierry Fournier, Martin J. Aryee
Publikováno v:
Epigenetics, Vol 12, Iss 9, Pp 793-803 (2017)
The placenta relies on phenotypes that are characteristic of cancer to successfully implant the embryo in the uterus during early pregnancy. Notably, it has to invade its host tissues, promote angiogenesis—while surviving hypoxia—, and escape the
Externí odkaz:
https://doaj.org/article/0352197b59a447b78d30ca7d40d9ee16