Zobrazeno 1 - 4
of 4
pro vyhledávání: '"David Kent Herron"'
Autor:
Xiaoling Xia, William Thomas Mcmillen, Jonathan Michael Yingling, David Kent Herron, J. Scott Sawyer, Michael L. Jones, Scott A. Watkins, Mort Nicholas A, John W. Lampe, Beight Douglas W, Brooks Harold Burns, Sheng-Bin Peng, Lei Yan
Publikováno v:
Biochemistry. 44:2293-2304
Transforming growth factor beta (TGF-beta) signaling pathways regulate a wide variety of cellular processes including cell proliferation, differentiation, extracellular matrix deposition, development, and apoptosis. TGF-beta type-I receptor (TbetaRI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a0b2794c1f42be3d90638b5102acc0
https://doi.org/10.1021/bi048851x
https://doi.org/10.1021/bi048851x
Autor:
Edward C R Smith, William Thomas Mcmillen, Mccowan Jefferson Ray, Lei Yan, Mort Nicholas A, Michael L. Jones, Bryan D. Anderson, Robert M. Campbell, Faming Zhang, John W. Lampe, Leonard C Weir, David Kent Herron, Stephen Parsons, Jonathan Michael Yingling, Beight Douglas W, J. Scott Sawyer, Michal Vieth
Publikováno v:
Journal of Medicinal Chemistry. 46:3953-3956
Pyrazole-based inhibitors of the transforming growth factor-beta type I receptor kinase domain (TbetaR-I) are described. Examination of the SAR in both enzyme- and cell-based in vitro assays resulted in the emergence of two subseries featuring differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79265d282a8256455dee4b376e4bc42
https://doi.org/10.1021/jm0205705
https://doi.org/10.1021/jm0205705
Autor:
Stephen Parsons, Lei Yan, Bryan D. Anderson, Karen S. Britt, Edward C. R. Smith, Mort Nicholas A, Hong-Yu Li, Jill R. Wagner, Faming Zhang, J. Scott Sawyer, Theodore Goodson, William Thomas Mcmillen, Beight Douglas W, Jonathan Michael Yingling, David Kent Herron, Robert M. Campbell
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
We have expanded our previously reported series of pyrazole-based inhibitors of the TGF-beta type I receptor kinase domain (TbetaR-I) to now include new 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole analogues. Limited examination of the SAR of this new serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6957b2c2b7d8fe16777b61c299be54b
https://pubmed.ncbi.nlm.nih.gov/15177479
https://pubmed.ncbi.nlm.nih.gov/15177479
Autor:
Robert J. Boyd, William T. Jackson, Larry L. Froelich, Timothy E. Aldridge, David Kent Herron, Richard Waltz Harper
Publikováno v:
Journal of medicinal chemistry. 37(15)
A series of (hydroxyphenyl)pyrazoles was designed by molecular modeling comparison with the LTB4 structure and prepared for evaluation as LTB4 receptor antagonists, culminating in 4-ethyl-5-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]-2-(1H-pyrazol -3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60a70090c87219b110e854d1c8714f3
https://pubmed.ncbi.nlm.nih.gov/8057289
https://pubmed.ncbi.nlm.nih.gov/8057289