Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David Karanian"'
Autor:
Sarah N. Campion, Christopher J. Bowman, Antje Fuchs, David Karanian, Payal Rana, Gregg D. Cappon
Publikováno v:
Birth defects researchREFERENCES.
Achondroplasia is an autosomal disorder caused by point mutation in the gene encoding fibroblast growth factor receptor 3 (FGFR3) and resulting in gain of function. Recifercept is a potential disease modifying treatment for achondroplasia and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3261062f97b1f60d4f7ae6a010cfedae
https://pubmed.ncbi.nlm.nih.gov/36367445
https://pubmed.ncbi.nlm.nih.gov/36367445
Autor:
Kelly R. Bales, Anabella Villalobos, David Riddell, Shawn D. Doran, Christopher Ryan Butler, Bruce N. Rogers, Lorraine F. Lanyon, Karamjeet Pandher, Claude Ambroise, Ashley Robshaw, Gabriela Barreiro, Christopher Houle, Kevin Ogilvie, Brian T. O’Neill, Erik Alphie Lachapelle, Germaine Boucher, Xinjun Hou, Katherine Hales, David Karanian, Michael Aaron Brodney, Leanne M. Buzon, Kimberly Lapham, Lei Zhang, Luis Martinez-Alsina, Charles E. Nolan, Claire M. Steppan, Cathleen Gonzales, John C. Murray, Cheng Chang, Jason K. Dutra, Elizabeth Mary Beck
Publikováno v:
Journal of Medicinal Chemistry. 61:4476-4504
A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease is the alignment of potency, drug-like properties, and selectivity over related aspartyl proteases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16220e824d55c04d1dd3342582ab393
https://doi.org/10.1021/acs.jmedchem.8b00246
https://doi.org/10.1021/acs.jmedchem.8b00246
Autor:
Michael Aaron Brodney, Michael De Vivo, Ann S. Wright, Stephen Jenkinson, Shawn D. Doran, Patrick Robert Verhoest, Maria S. Brown, Gregory S. Walker, Christopher John Helal, Antonia F. Stepan, Travis T. Wager, R. Scott Obach, Ethan Lawrence Fisher, Tuan P. Tran, Bethany L. Kormos, Raman Sharma, Cheng Chang, Edward X. Yang, Rebecca E. O’Connor, David Karanian
Publikováno v:
ACS Medicinal Chemistry Letters
Late-stage oxidation using liver microsomes was applied to phosphodiesterase 2 inhibitor 1 to reduce its clearance by cytochrome P450 enzymes, introduce renal clearance, and minimize the risk for victim drug–drug interactions. This approach yielded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebf76f135a3421c85311e525117027f
https://pubmed.ncbi.nlm.nih.gov/29456790
https://pubmed.ncbi.nlm.nih.gov/29456790
Autor:
William S. Nowland, Timothy M. Coskran, Elsa G. Barbacci-Tobin, Timothy R. Winton, Steven W. Kumpf, Sarah N. Campion, Robert E. Chapin, Scott Davenport, Christopher Houle, Randal D. Streck, David Karanian
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:325-332
Treatment-induced epididymal inflammation and granuloma formation is only an occasional problem in preclinical drug development, but it can effectively terminate the development of that candidate molecule. Screening for backup molecules without that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19af30dcb0ea577014281fc8d29754d
https://doi.org/10.1002/bdrb.21115
https://doi.org/10.1002/bdrb.21115
Autor:
Jeffrey W Brulet, Christopher W. am Ende, Michael Aaron Brodney, Sherry Niessen, Brian T. O’Neill, Kevin Atchison, Douglas S. Johnson, Kieran F. Geoghegan, David Riddell, Charles E. Nolan, Elizabeth Mary Beck, Graham M. West, David Karanian, Cheng Chang, Shawn D. Doran, Xinjun Hou, Christopher Houle, Andrea M. Zuhl, Claude Ambroise, Joshua C. Judkins
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications
Inhibition of β-secretase BACE1 is considered one of the most promising approaches for treating Alzheimer's disease. Several structurally distinct BACE1 inhibitors have been withdrawn from development after inducing ocular toxicity in animal models,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b96cd9d34c562c2e27085edae0e78d
https://doi.org/10.1038/ncomms13042
https://doi.org/10.1038/ncomms13042
Autor:
Kelly R. Bales, David Karanian, Michael Aaron Brodney, Shawn D. Doran, Cathleen Gonzales, Katherine Hales, Germaine Boucher, Lorraine F. Lanyon, Charles E. Nolan, Karamjeet Pandher, Christopher Houle, Claude Ambroise, Cheng Chang
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69664bc0d18a8c28039de61358dcc6fb
https://doi.org/10.1016/j.jalz.2016.06.854
https://doi.org/10.1016/j.jalz.2016.06.854
Publikováno v:
Psychopharmacology. 183:41-53
Dopamine signaling in the nucleus accumbens (NAc) plays an important role in regulating drug-taking and drug-seeking behaviors, but the role of D(1)- and D(2)-like receptors in this regulation remains unclear.Our objective was to study the role of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1721e7c89a5a5f33b77a4b7f7192815f
https://doi.org/10.1007/s00213-005-0133-1
https://doi.org/10.1007/s00213-005-0133-1
Autor:
Robert E, Chapin, Timothy R, Winton, William S, Nowland, Steven W, Kumpf, Scott, Davenport, David, Karanian, Randal D, Streck, Timothy M, Coskran, Elsa G, Barbacci-Tobin, Christopher, Houle, Sarah N, Campion
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 101(4)
Treatment-induced epididymal inflammation and granuloma formation is only an occasional problem in preclinical drug development, but it can effectively terminate the development of that candidate molecule. Screening for backup molecules without that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a56865353922359631eaa526ede7549c
https://pubmed.ncbi.nlm.nih.gov/25044418
https://pubmed.ncbi.nlm.nih.gov/25044418