Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D

Autor: Konstantin Stark, Stefanie Dimmeler, Kavi Devraj, Markus Hecker, Thomas Korff, David Kaluza, Shemsi Demolli, Tina Lucas, Stefan Liebner, Steffen Massberg, Annekathrin Eckart, Yosif Manavski, Christoph M. Zehendner, Reinier A. Boon, Anuradha Doddaballapur

Publikováno v: Cardiovascular Research, 113(6), 681-691. Oxford University Press
Demolli, S, Doddaballapur, A, Devraj, K, Stark, K, Manavski, Y, Eckart, A, Zehendner, C M, Lucas, T, Korff, T, Hecker, M, Massberg, S, Liebner, S, Kaluza, D, Boon, R A & Dimmeler, S 2017, ' Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D ', Cardiovascular Research, vol. 113, no. 6, pp. 681-691 . https://doi.org/10.1093/cvr/cvx032

Aims Vessel maturation involves the recruitment of mural cells such as pericytes and smooth muscle cells. Laminar shear stress is a major trigger for vessel maturation, but the molecular mechanisms by which shear stress affects recruitment of pericyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b06488931bf935646ad707bfefa237
http://www.scopus.com/inward/record.url?scp=85019114670&partnerID=8YFLogxK

The Polarity Protein Scrib Is Essential for Directed Endothelial Cell Migration

Autor: Johannes A. Eble, Benno Jungblut, Katalin Wandzioch, U. Ruth Michaelis, Michael Potente, Jean-Paul Borg, Marie-Josée Santoni, Emmanouil Chavakis, Heinrich Heide, Christoph Kruse, Ralf P. Brandes, Yosif Manavski, David Kaluza

Publikováno v: Circulation Research. 112:924-934

Rationale: Polarity proteins are involved in the apico-basal orientation of epithelial cells, but relatively little is known regarding their function in mesenchymal cells. Objective: We hypothesized that polarity proteins also contribute to endotheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c44e7dd6ac4d3fddf6d172ea94e4ba
https://doi.org/10.1161/circresaha.112.300592

MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A

Autor: Andreas M. Zeiher, Angelika Bonauer, Jes Niels Boeckel, Andrea Knau, Jens Kroll, Timo Frömel, Eduard Hergenreider, Reinier A. Boon, Katrin Bennewitz, Stefanie Dimmeler, David Kaluza, Ingrid Fleming, Carmen Urbich, Carmen Doebele

Publikováno v: Urbich, C, Kaluza, D, Frömel, T, Knau, A, Bennewitz, K, Boon, R A, Bonauer, A, Doebele, C, Boeckel, J N, Hergenreider, E, Zeiher, A M, Kroll, J, Fleming, I & Dimmeler, S 2012, ' MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A ', Blood, vol. 119, no. 6, pp. 1607-1618 . https://doi.org/10.1182/blood-2011-08-373886
Blood, 119(6), 1607-1618. American Society of Hematology
Blood

MicroRNAs (miRs) are small RNAs that regulate gene expression at the posttranscriptional level. miR-27 is expressed in endothelial cells, but the specific functions of miR-27b and its family member miR-27a are largely unknown. Here we demonstrate tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e4b0e068e0cfc69c77f267221296d9
https://doi.org/10.1182/blood-2011-08-373886

JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells

Autor: Tina Lucas, Karine Tréguer, Marcus Krüger, David Kaluza, Annika Luczak, Simone F. Glaser, Stefanie Dimmeler, Andreas W. Heumüller, Anja Derlet, Kisho Ohtani, Christoph M. Zehendner, Anuradha Doddaballapur, Jes Niels Boeckel

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 36(7)

Objective— Jumonji C (JmjC) domain–containing proteins modify histone and nonhistone proteins thereby controlling cellular functions. However, the role of JmjC proteins in angiogenesis is largely unknown. Here, we characterize the expression of J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42bd432831c23012843472a967f5c4d
https://pubmed.ncbi.nlm.nih.gov/27199445

MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2

Autor: Reinhard Henschler, Shemsi Demolli, Soniya Savant, Markus Hecker, Anuradha Doddaballapur, Victoria Lang, Carmen Doebele, Emmanouil Chavakis, Stefanie Dimmeler, Beate Fisslthaler, Reinier A. Boon, David Kaluza, Hellmut G. Augustin, Manlio Vinciguerra, Sergio Sciacca

Publikováno v: Demolli, S, Doebele, C, Doddaballapur, A, Lang, V, Fisslthaler, B, Chavakis, E, Vinciguerra, M, Sciacca, S, Henschler, R, Hecker, M, Savant, S, Augustin, H G, Kaluza, D, Dimmeler, S & Boon, R A 2015, ' MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2 ', Journal of Molecular and Cellular Cardiology, vol. 88, pp. 111-119 . https://doi.org/10.1016/j.yjmcc.2015.10.009
Journal of Molecular and Cellular Cardiology, 88, 111-119. Academic Press Inc.

MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression. Laminar blood flow induces atheroprotective gene expression in endothelial cells (ECs) in part by upregulating the transcription factor KLF2. Here, we identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aa6ec4d52d205edb71dd45f53c7cac
https://research.vumc.nl/en/publications/bed41c92-38a8-4867-a577-b39d1b82775b