Zobrazeno 1 - 10
of 37
pro vyhledávání: '"David K. Worthylake"'
Autor:
Partha K. Chandra, Stephen E. Braun, Sudipa Maity, Jorge A. Castorena-Gonzalez, Hogyoung Kim, Jeffrey G. Shaffer, Sinisa Cikic, Ibolya Rutkai, Jia Fan, Jessie J. Guidry, David K. Worthylake, Chenzhong Li, Asim B. Abdel-Mageed, David W. Busija
Publikováno v:
Viruses, Vol 15, Iss 3, p 794 (2023)
Despite the suppression of human immunodeficiency virus (HIV) replication by combined antiretroviral therapy (cART), 50–60% of HIV-infected patients suffer from HIV-associated neurocognitive disorders (HAND). Studies are uncovering the role of extr
Externí odkaz:
https://doaj.org/article/229353644e9f4202a6485649497b10fd
Autor:
Mohammad Sadraeian, Francisco E. G. Guimarães, Ana P. U. Araújo, David K. Worthylake, Louis Jr. LeCour, Seth H. Pincus
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Immunotoxins (ITs), which consist of antibodies conjugated to toxins, have been proposed as a treatment for cancer and chronic infections. To develop and improve the ITs, different toxins such as ricin, have been used, aiming for higher effi
Externí odkaz:
https://doaj.org/article/0c255a1dc2eb4c78b4fafd46e461bdcf
Autor:
Samuel C. Okpechi, Shengli Dong, Hassan Yousefi, Jessie J. Guidry, David A. Otohinoyi, David K. Worthylake, Chindo Hicks, Suresh K. Alahari
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::898630b526cafec81acb8c2df3c81904
https://doi.org/10.1096/fasebj.2022.36.s1.0r434
https://doi.org/10.1096/fasebj.2022.36.s1.0r434
Autor:
Partha K. Chandra, Stephen E. Braun, Melody C. Baddoo, Hogyoung Kim, Jorge A. Castorena‐Gonzalez, Sinisa Cikic, Ibolya Rutkai, Jessie J. Guidry, David K. Worthylake, Erik K. Flemington, Asim B. Abdel‐Mageed, David W. Busija
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d657ff3fa388bca6d7b79d833df7621c
https://doi.org/10.1096/fasebj.2022.36.s1.r1928
https://doi.org/10.1096/fasebj.2022.36.s1.r1928
Publikováno v:
Structure. 24:1499-1508
In signaling, Rho-family GTPases bind effector proteins and alter their behavior. Here we present the crystal structure of Cdc42·GTP bound to the GTPase-activating protein (GAP)-related domain (GRD) of IQGAP2. Four molecules of Cdc42 are bound to tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7958896e61e127ea3ee3033c43078914
https://doi.org/10.1016/j.str.2016.06.016
https://doi.org/10.1016/j.str.2016.06.016
Autor:
David K. Worthylake, Ana Paula Ulian de Araújo, Francisco Eduardo Gontijo Guimarães, Mohammad Sadraeian, Louis LeCour, Seth H. Pincus
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Immunotoxins (ITs), which consist of antibodies conjugated to toxins, have been proposed as a treatment for cancer and chronic infections. To develop and improve the ITs, different toxins such as ricin, have been used, aiming for higher efficacy agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974b4dcb388d1e16d60b1b6d81ba4d7b
https://hdl.handle.net/10453/161402
https://hdl.handle.net/10453/161402
Autor:
Coyne Cp, Seth H. Pincus, Dean H. Hamer, Gang Chen, Anderson Frank, Deborah T. Weiss, Victor Ghetie, Ellen S. Vitetta, Grace A. Maresh, James E. Robinson, Kejing Song, Shiu Lok Hu, David K. Worthylake, Patricia Polacino, John W. Marks, Michael G. Rosenblum, Hye Kyung Chung
Publikováno v:
Journal of Virology. 91
The envelope (Env) glycoprotein of HIV is expressed on the surface of productively infected cells and can be used as a target for cytotoxic immunoconjugates (ICs), in which cell-killing moieties, including toxins, drugs, or radionuclides, are chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d127f83f470f5a3677b154b6bcbc61
https://doi.org/10.1128/jvi.01360-16
https://doi.org/10.1128/jvi.01360-16
Autor:
Jessie J Guidry, Rebecca A. Worthylake, David K. Worthylake, Kelly A. Williams, Sylvester Tumusiime, Manish K. Rana, Swapnil S. Kher, Vinodh B. Kurella
Publikováno v:
Biochemical and Biophysical Research Communications. 381:393-396
ROCKII kinase activity is known to be regulated by Rho GTPase binding; however, the context-specific regulation of ROCKII is not clearly understood. We pursued the C-terminal PH domain as a candidate domain for regulating ROCKII function. A proteomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962551ca243b75cba1950edbc0aa8ad5
https://doi.org/10.1016/j.bbrc.2009.02.056
https://doi.org/10.1016/j.bbrc.2009.02.056
Publikováno v:
Journal of Molecular Biology. 368:1307-1320
Rho-family GTPases are activated by the exchange of bound GDP for GTP, a process that is catalyzed by Dbl-family guanine nucleotide exchange factors (GEFs). The catalytic unit of Dbl-family GEFs consists of a Dbl-homology (DH) domain followed almost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706e335478502ec00e8c6239c21ac0a9
https://doi.org/10.1016/j.jmb.2007.02.060
https://doi.org/10.1016/j.jmb.2007.02.060
Autor:
Louis LeCour, Chau Wen Chou, David K. Worthylake, Kristen Krup, Yanguang Cong, Megan A. Macnaughtan, Miao Luo, Li Shen, Octavia Y. Goodwin, Kyla M. Frohlich
Secretion of effector proteins into the eukaryotic host cell is required for Chlamydia trachomatis virulence. In the infection process, Scc1 and Scc4, two chaperones of the type III secretion (T3S) system, facilitate secretion of the important effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942e249f2c0eceea38ac762649f30955
https://europepmc.org/articles/PMC4653673/
https://europepmc.org/articles/PMC4653673/