Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David K. Stiles"'
Autor:
Richard Grondin, Pei Ge, Qingmin Chen, Jessica E Sutherland, Zhiming Zhang, Don M Gash, David K Stiles, Gregory R Stewart, Dinah W Y Sah, William F Kaemmerer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression o
Externí odkaz:
https://doaj.org/article/2560f36a757e4533913335385c14852e
Autor:
Zhiming Zhang, Don M. Gash, Brian D. Nelson, Xiaotong Fan, David K. Stiles, Peter A. Hardy, Yi Ai
Publikováno v:
Journal of Neurosurgery. 123:1569-1577
OBJECT Assessing the safety and feasibility of chronic delivery of compounds to the brain using convection-enhanced delivery (CED) is important for the further development of this important therapeutic technology. The objective of this study was to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b513d54c95c031d5e6e77c10748f635
https://doi.org/10.3171/2015.1.jns132345
https://doi.org/10.3171/2015.1.jns132345
Autor:
Douglas Ulen Gwost, Verbena Kosovrasti, Michael Meys, Dinah W.Y. Sah, Gregory R. Stewart, Peter A. Hardy, Lubomir Nechev, Pei Ge, Muthiah Manoharan, Klaus Charisse, Yi Ai, Lubomir Tchangov, David K. Stiles, Don M. Gash, Andrei Guzaev, Richard Grondin, Peter T. Nelson, Zhiming Zhang, Brian D. Nelson, William F. Kaemmerer, Martin Maier, Mark T. Butt
Publikováno v:
Experimental Neurology. 233:463-471
Huntington's disease is an autosomal dominant neurodegenerative disease caused by a toxic gain of function mutation in the huntingtin gene (Htt). Silencing of Htt with RNA interference using direct CNS delivery in rodent models of Huntington's diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e37e95e67330c02b8b35866ede200a
https://doi.org/10.1016/j.expneurol.2011.11.020
https://doi.org/10.1016/j.expneurol.2011.11.020
Autor:
Barbara Oakley, David K. Stiles
Publikováno v:
IEEE Transactions on Biomedical Engineering. 50:916-921
FEM software was used to determine the feasibility of characterizing various types of atherosclerotic lesions in vivo. This was accomplished by simulating two electrodes as being attached to an angioplasty balloon in the coronary artery. The electrod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0878bd94cd2e8f903bb4591a5260d2
https://doi.org/10.1109/tbme.2003.813545
https://doi.org/10.1109/tbme.2003.813545
Autor:
David K. Stiles, Douglas Ulen Gwost
Publikováno v:
EMBC
A 64-run, 2-level partial factorial experimental analysis was conducted on a 2D axisymmetric finite-element model of the convection-enhanced drug delivery to the parenchyma of the brain. The purpose of this ANOVA analysis was to determine the relativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6163fca295b94f2c53c7aeeb439d9b96
https://doi.org/10.1109/iembs.2006.260548
https://doi.org/10.1109/iembs.2006.260548
Autor:
Barbara Oakley, David K. Stiles
Publikováno v:
Bioelectromagnetics. 26(1)
Results are presented here of experimental measurements using a four-point electrode technique to measure the complex impedance of bovine aorta submerged in Ringer's solution. Impedance measurements were taken at 250 microm intervals, ranging from 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9c637f0b8e1bdefdbadb3d55723021
https://pubmed.ncbi.nlm.nih.gov/15605396
https://pubmed.ncbi.nlm.nih.gov/15605396
Autor:
Barbara Oakley, David K. Stiles
Publikováno v:
Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).
The complex impedance that would be measured by a four-point electrode on the intimal surface of type Va and Vb atherosclerotic lesions was simulated using two different electromagnetic software programs. One program used a nonconformal hexahedral me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76fd58cba5555e2412effd2f4b1d66ec
https://doi.org/10.1109/iembs.2003.1280772
https://doi.org/10.1109/iembs.2003.1280772
Autor:
David K. Stiles, Barbara A. Oakley
Publikováno v:
Bioelectromagnetics; Jan2005, Vol. 26 Issue 1, p54-58, 5p