Zobrazeno 1 - 10
of 36
pro vyhledávání: '"David K. Okita"'
Autor:
David K. Okita, Katayoon Karimi, Fazel Shokri, Soheila Gharagozlou, Bianca M. Conti-Fine, Monica Milani, Ramazan Ali Sharifian, Jalal Khoshnoodi
Publikováno v:
Thrombosis and Haemostasis. 101:834-839
SummaryDevelopment of antibodies (Ab) that either block the function of coagulation factor VIII (FVIII) (inhibitors) or clear it from circulation, seriously complicate the treatment of haemophilia A patients with FVIII products. Autoantibodies which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be524ab3d16e9c09b94d0044acff785b
https://doi.org/10.1160/th08-08-0508
https://doi.org/10.1160/th08-08-0508
Publikováno v:
Journal of Thrombosis and Haemostasis. 2:1385-1394
Severe hemophilia A patients treated with factor (F)VIII may develop antibodies (Ab) that block FVIII function (inhibitors). Autoimmune inhibitors may develop in subjects without congenital hemophilia, and cause acquired hemophilia. Hemophiliacs with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae23856a19464dfab228fa41532c127
https://doi.org/10.1111/j.1538-7836.2004.00850.x
https://doi.org/10.1111/j.1538-7836.2004.00850.x
Autor:
Kathleen P. Pratt, David W. Scott, David K. Okita, Brenda Diethelm-Okita, Bianca M. Conti-Fine, Jiahua Qian, Ekram Ellaban
Publikováno v:
Thrombosis and Haemostasis. 92:522-528
SummaryFormation of inhibitor antibodies to factor VIII (FVIII) is a major complication of FVIII replacement therapy for hemophilia A patients, and it occurs through a T-cell dependent process. The C2 domain of FVIII contains epitopes that are recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9683c33f3f30d908c4742b38087f09
https://doi.org/10.1160/th03-12-0755
https://doi.org/10.1160/th03-12-0755
Publikováno v:
Annals of the New York Academy of Sciences. 998:384-387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aec4a65ecc8fef3b350782721923e5
https://doi.org/10.1196/annals.1254.046
https://doi.org/10.1196/annals.1254.046
Autor:
Huan Yang, Chella S. David, Teh Sheng Chan, Premkumar Christadoss, Bianca M. Conti-Fine, Elzbieta Goluszko, Mathilde A. Poussin, David K. Okita
Publikováno v:
Annals of the New York Academy of Sciences. 998:375-378
We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR alpha subunit. The cytoplasmic H-AChR peptide alpha320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8xDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea7ca03f61845b3bc83ea79f5d8dfb4
https://doi.org/10.1196/annals.1254.044
https://doi.org/10.1196/annals.1254.044
Publikováno v:
The Journal of Immunology. 170:604-612
Myasthenia gravis (MG) is a T cell-dependent, Ab-mediated autoimmune disease. Ab against muscle acetylcholine receptor (AChR) cause the muscular weakness that characterizes MG and its animal model, experimental MG (EMG). EMG is induced in C57BL6 (B6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8836bf5cb9a951a539391ee2ceb29e
https://doi.org/10.4049/jimmunol.170.1.604
https://doi.org/10.4049/jimmunol.170.1.604
Autor:
Elzbieta Goluszko, Bianca M. Conti-Fine, Teh Sheng Chan, Huan Yang, Mathilde A. Poussin, David K. Okita, Premkumar Christadoss, Chella S. David
Publikováno v:
Journal of Clinical Investigation. 109:1111-1120
Susceptibility to myasthenia gravis (MG) is positively linked to expression of HLA-DQ8 and DR3 molecules and negatively linked to expression of the DQ6 molecule. To elucidate the molecular basis of this association, we have induced experimental autoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34129e262bc24a2d1f216c71ce390146
https://doi.org/10.1172/jci14255
https://doi.org/10.1172/jci14255
Autor:
Peter I. Karachunski, Wei Wang, Cristina Monfardini, Jon Lindstrom, David K. Okita, Monica Milani, Bianca M. Conti-Fine, Norma Ostlie
Publikováno v:
Journal of Neuroimmunology. 123:123-134
Nasal administration of synthetic CD4(+) epitopes of the acetylcholine receptor (AChR) prevents experimental myasthenia gravis (EMG) in C57Bl/6 mice, but not in IL4-deficient C57Bl/6 (IL4(-/-)) mice. Here we verify that nasal tolerance requires IL4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1e750abd3c7c136c9d0dc2235addb0
https://doi.org/10.1016/s0165-5728(01)00454-4
https://doi.org/10.1016/s0165-5728(01)00454-4
Autor:
Bianca M. Conti-Fine, Huiyun Wu, Ernie Parker, Jiahua Qian, David K. Okita, Mark T. Reding, Pete Lollar, Leon W. Hoyer
Publikováno v:
Thrombosis and Haemostasis. 85:125-133
SummaryMice genetically deficient in factor VIII (fVIII) are a model of hemophilia A. As a first step to reproduce in this mouse model what occurs over time in hemophilia A patients treated with human fVIII (hfVIII), we have investigated the time cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd4e87c45a654c61297d1109989f86d
https://doi.org/10.1055/s-0037-1612915
https://doi.org/10.1055/s-0037-1612915
Autor:
Zeng Yu Wang, Henry J. Kaminski, Brenda Diethelm-Okita, David K. Okita, James F. Howard, Bianca M. Conti-Fine
Publikováno v:
Journal of Neuroimmunology. 108:29-39
We examined the proliferative response of blood CD4(+) cells to muscle acetylcholine receptor (AChR) subunits and the epitope repertoire of the epsilon and gamma subunits, in ocular myasthenia gravis (oMG) patients and healthy subjects. oMG patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16563fd1172435e2666d9b962e7f4d0
https://doi.org/10.1016/s0165-5728(00)00250-2
https://doi.org/10.1016/s0165-5728(00)00250-2