Zobrazeno 1 - 10
of 131
pro vyhledávání: '"David K. Cole"'
Autor:
Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering
Externí odkaz:
https://doaj.org/article/d2f84672e7fe4eb3b7df368784cf9d36
Autor:
Emily A. Bates, James A. Davies, Jana Váňová, Davor Nestić, Valerie S. Meniel, Sarah Koushyar, Tabitha G. Cunliffe, Rosie M. Mundy, Elise Moses, Hanni K. Uusi-Kerttula, Alexander T. Baker, David K. Cole, Dragomira Majhen, Pierre J. Rizkallah, Toby Phesse, John D. Chester, Alan L. Parker
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 43-56 (2022)
Oncolytic virotherapies (OV) hold immense clinical potential. OV based on human adenoviruses (HAdV) derived from HAdV with naturally low rates of pre-existing immunity will be beneficial for future clinical translation. We generated a low-seroprevale
Externí odkaz:
https://doaj.org/article/e338981455f0434ea7eb7c74250e7338
Autor:
Rory M. Crean, Bruce J. MacLachlan, Florian Madura, Thomas Whalley, Pierre J. Rizkallah, Christopher J. Holland, Catriona McMurran, Stephen Harper, Andrew Godkin, Andrew K. Sewell, Christopher R. Pudney, Marc W. van der Kamp, David K. Cole
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 443-456 (2020)
Immuno-oncology approaches that utilize T cell receptors (TCRs) are becoming highly attractive because of their potential to target virtually all cellular proteins, including cancer-specific epitopes, via the recognition of peptide-human leukocyte an
Externí odkaz:
https://doaj.org/article/468343d29a914222a4306cde545a8b9d
Autor:
Anna-Lisa Lanz, Giulia Masi, Nicla Porciello, André Cohnen, Deborah Cipria, Dheeraj Prakaash, Štefan Bálint, Roberto Raggiaschi, Donatella Galgano, David K. Cole, Marco Lepore, Omer Dushek, Michael L. Dustin, Mark S.P. Sansom, Antreas C. Kalli, Oreste Acuto
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109531- (2021)
Externí odkaz:
https://doaj.org/article/a6cb432e0b0a4011bea51b73db0ce5dd
Autor:
Alexander T. Baker, Alexander Greenshields-Watson, Lynda Coughlan, James A. Davies, Hanni Uusi-Kerttula, David K. Cole, Pierre J. Rizkallah, Alan L. Parker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Adenovirus based (AdV) vectors are promising platforms for therapeutics and vaccines, but receptor usage of serotypes in clinical development remains unclear. Here, based on crystal structures and modeling, Baker et al. show that HAdV-D26/48 fiber kn
Externí odkaz:
https://doaj.org/article/f0b1e1b1b41e4d7397fac97ab6273893
Autor:
Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885- (2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://doaj.org/article/ac1881b0cc804226bb104e9cab830657
Autor:
Thomas Whalley, Garry Dolton, Paul E. Brown, Aaron Wall, Linda Wooldridge, Hugo van den Berg, Anna Fuller, Jade R. Hopkins, Michael D. Crowther, Meriem Attaf, Robin R. Knight, David K. Cole, Mark Peakman, Andrew K. Sewell, Barbara Szomolay
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The strong links between (Human Leukocyte Antigen) HLA, infection and autoimmunity combine to implicate T-cells as primary triggers of autoimmune disease (AD). T-cell crossreactivity between microbially-derived peptides and self-peptides has been sho
Externí odkaz:
https://doaj.org/article/1a8fe277e505431893c2b64061e4a518
Autor:
Sarah A. E. Galloway, Garry Dolton, Meriem Attaf, Aaron Wall, Anna Fuller, Cristina Rius, Valentina Bianchi, Sarah Theaker, Angharad Lloyd, Marine E. Caillaud, Inge Marie Svane, Marco Donia, David K. Cole, Barbara Szomolay, Pierre Rizkallah, Andrew K. Sewell
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Recent immunotherapeutic approaches using adoptive cell therapy, or checkpoint blockade, have demonstrated the powerful anti-cancer potential of CD8 cytotoxic T-lymphocytes (CTL). While these approaches have shown great promise, they are only effecti
Externí odkaz:
https://doaj.org/article/eafad320a3c049e2a23c4b349b6aa310
Publikováno v:
Applied Sciences, Vol 11, Iss 9, p 4109 (2021)
The implementation of peptide-based molecules within the medical field has vast potential, owing to their unique nature and predictable physicochemical profiles. However, peptide therapeutic usage is hindered by delivery-related challenges, meaning t
Externí odkaz:
https://doaj.org/article/15e986f74ca94a65a147b2ecdaa3b047
Autor:
Christopher J. Holland, Bruce J. MacLachlan, Valentina Bianchi, Sophie J. Hesketh, Richard Morgan, Owen Vickery, Anna M. Bulek, Anna Fuller, Andrew Godkin, Andrew K. Sewell, Pierre J. Rizkallah, Stephen Wells, David K. Cole
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in
Externí odkaz:
https://doaj.org/article/e3ef9d8a5f414323a84758bdf8c25ac1