Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David K. Breslow"'
Autor:
Tracy A. Knight, Shawn Gray, David K. Breslow, Kendall E. Oliver, Margaret C. Kennedy, Anil Kumar Ganga, Mitsunori Fukuda, Enrique M. De La Cruz, Mai E. Oguchi, Yuta Homma
Publikováno v:
Curr Biol
The primary cilium is an essential organizing center for signal transduction, and ciliary defects cause congenital disorders known collectively as ciliopathies.(1–3) Primary cilia form by two pathways that are employed in a cell type- and tissue-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acd04f85915f016beec2bd100d85529
https://europepmc.org/articles/PMC8282722/
https://europepmc.org/articles/PMC8282722/
Autor:
Fan Ye, David K Breslow, Elena F Koslover, Andrew J Spakowitz, W James Nelson, Maxence V Nachury
Publikováno v:
eLife, Vol 2 (2013)
The dynamic organization of signaling cascades inside primary cilia is key to signal propagation. Yet little is known about the dynamics of ciliary membrane proteins besides a possible role for motor-driven Intraflagellar Transport (IFT). To characte
Externí odkaz:
https://doaj.org/article/b80410ab2f0741ad817a1ee410b6b6e0
Autor:
Kendall E. Oliver, Margaret C. Kennedy, Mitsunori Fukuda, Shawn Gray, David K. Breslow, Anil Kumar Ganga, Enrique M. De La Cruz, Mai E. Oguchi, Yuta Homma, Tracy A. Knight
Primary cilia form by two pathways: an extracellular pathway in which the cilium grows out from the cell surface and an intracellular pathway in which the nascent cilium forms inside the cell. Here we identify the GTPase Rab34 as a selective mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d547261856e366d8e30bc02070e9c6b4
https://doi.org/10.1101/2020.10.29.360891
https://doi.org/10.1101/2020.10.29.360891
Autor:
Michael C. Bassik, Sascha Hoogendoorn, Brandon Vu, Gaelen T. Hess, Kyuho Han, Maxence V. Nachury, Margaret C. Kennedy, David W. Morgens, Adam R Kopp, Amy Li, James K. Chen, David K. Breslow
Publikováno v:
Nature genetics
Nature genetics, vol 50, iss 3
Nature genetics, vol 50, iss 3
Primary cilia organize Hedgehog signaling and shape embryonic development, and their dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic screen for Hedgehog signaling by engineering antibiotic-based selection of Hed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b9323f576b7bdb66c54cd865af2bde
https://doi.org/10.1038/s41588-018-0054-7
https://doi.org/10.1038/s41588-018-0054-7
Autor:
Seongjin Seo, Qihong Zhang, Kevin Bugge, David K Breslow, Charles C Searby, Maxence V Nachury, Val C Sheffield
Publikováno v:
PLoS Genetics, Vol 7, Iss 11, p e1002358 (2011)
Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis. Bardet-Biedl Syndrome (BBS) proteins are involved in ma
Externí odkaz:
https://doaj.org/article/78e83881b45b41118db6628f5da3ef93
Autor:
Andrew J. Holland, David K. Breslow
Publikováno v:
Annual review of biochemistry. 88
The centriole is an ancient microtubule-based organelle with a conserved nine-fold symmetry. Centrioles form the core of centrosomes, which organize the interphase microtubule cytoskeleton of most animal cells and form the poles of the mitotic spindl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24228d0b447a16b8ddfe5e859d3ee423
https://pubmed.ncbi.nlm.nih.gov/30601682
https://pubmed.ncbi.nlm.nih.gov/30601682
A comprehensive portrait of cilia and ciliopathies from a CRISPR-based screen for Hedgehog signaling
Autor:
David K. Breslow, James K. Chen, Gaelen T. Hess, Kyuho Han, Amy Li, Maxence V. Nachury, Adam R Kopp, Michael C. Bassik, Sascha Hoogendoorn, David W. Morgens, Brandon Vu
The primary cilium organizes Hedgehog signaling, shapes embryonic development and is the unifying cause of the ciliopathies. We conducted a functional genomic screen for Hedgehog signaling by engineering antibiotic-based selection of Hedgehog-respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d000d09a00e5d86c60d82c6fd3f7c102
https://doi.org/10.1101/156059
https://doi.org/10.1101/156059
Autor:
David K. Breslow
Publikováno v:
Developmental Cell. 46:527-528
Down syndrome is a developmental disorder caused by chromosome 21 trisomy, whereas ciliopathies result from defective primary cilia. In this issue of Developmental Cell, Galati et al. (2018) establish a link between these diseases, finding that ciliu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df42198003a167de36a4999ba74eb081
https://doi.org/10.1016/j.devcel.2018.08.017
https://doi.org/10.1016/j.devcel.2018.08.017
Autor:
Maxence V. Nachury, David K. Breslow, Andrew J. Spakowitz, Elena F. Koslover, Federica Seydel
Publikováno v:
Breslow, DK; Koslover, EF; Seydel, F; Spakowitz, AJ; & Nachury, MV. (2013). An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier. JOURNAL OF CELL BIOLOGY, 203(1), 129-147. doi: 10.1083/jcb.201212024. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2nz052f1
The Journal of Cell Biology
The Journal of Cell Biology
The ciliary permeability barrier is mechanistically distinct from other cellular diffusion barriers and allows soluble proteins under ∼100 kD in size to enter cilia in the absence of active transport.
Specific proteins are concentrated within
Specific proteins are concentrated within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3505ed17826938be44293ac81e8586f6
https://doi.org/10.1083/jcb.201212024
https://doi.org/10.1083/jcb.201212024
Autor:
Sigurd Braun, Heather W Newman, Nevan J. Krogan, Sean R. Collins, Dale M. Cameron, David K. Breslow, Jonathan S. Weissman, Hiten D. Madhani, Maya Schuldiner, Jacob Stewart-Ornstein
Publikováno v:
Nature Methods. 5:711-718
Functional genomic studies in Saccharomyces cerevisiae have contributed enormously to our understanding of cellular processes. Their full potential, however, has been hampered by the limited availability of reagents to systematically study essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350b51badc4f7d919bf8d587fedb7f3c
https://doi.org/10.1038/nmeth.1234
https://doi.org/10.1038/nmeth.1234