Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David K. Schaffer"'
Autor:
Dharaminder Singh, Sudhir P Deosarkar, Elaine Cadogan, Vikki Flemington, Alysha Bray, Jingwen Zhang, Ronald S Reiserer, David K Schaffer, Gregory B Gerken, Clayton M Britt, Erik M Werner, Francis D Gibbons, Tomasz Kostrzewski, Christopher E Chambers, Emma J Davies, Antonio Ramos Montoya, Jacqueline H L Fok, David Hughes, Kristin Fabre, Matthew P Wagoner, John P Wikswo, Clay W Scott
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001624 (2022)
Test compounds used on in vitro model systems are conventionally delivered to cell culture wells as fixed concentration bolus doses; however, this poorly replicates the pharmacokinetic (PK) concentration changes seen in vivo and reduces the predictiv
Externí odkaz:
https://doaj.org/article/55008e3ff350462b806cde78444e0ef3
Autor:
Niloufar A. Boghdeh, Kenneth H. Risner, Michael D. Barrera, Clayton M. Britt, David K. Schaffer, Farhang Alem, Jacquelyn A. Brown, John P. Wikswo, Aarthi Narayanan
Publikováno v:
Viruses, Vol 14, Iss 12, p 2799 (2022)
The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS). Infections by many acutely infectious viruses such as alphaviruses and
Externí odkaz:
https://doaj.org/article/fe4563b4c86244a9a3719032e2a49db1
Autor:
David K. Schaffer, Frank E. Block, M. Diana Neely, Jennifer R. McKenzie, John P. Wikswo, David E. Cliffel, Dusty R. Miller, Dmitry A. Markov, Erik M. Werner, Kevin C. Ess, Ethan S. McClain, Laura C. Armstrong, Aaron B. Bowman, Adam R. Travis
Publikováno v:
Sens Actuators B Chem
There is a need for valves and pumps that operate at the microscale with precision and accuracy, are versatile in their application, and are easily fabricated. To that end, we developed a new rotary planar multiport valve to faithfully select solutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecc64658fa4c13ff94f2640dd50d797
https://pubmed.ncbi.nlm.nih.gov/34092923
https://pubmed.ncbi.nlm.nih.gov/34092923
Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment
Autor:
John A. McLean, Stacy D. Sherrod, Philip Owens, Ann Richmond, Philip C. Samson, John P. Wikswo, David K. Schaffer, Matthew Rogers, Andrew C. Johnson, Tammy Sobolik, Simona G. Codreanu
Publikováno v:
Biomicrofluidics. 12(3)
The interaction of cancer cells with the stromal cells and matrix in the tumor microenvironment plays a key role in progression to metastasis. A better understanding of the mechanisms underlying these interactions would aid in developing new therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a19fabd6f88ca6e1275874043317538
https://pubmed.ncbi.nlm.nih.gov/29774083
https://pubmed.ncbi.nlm.nih.gov/29774083
Autor:
Eduardo A. Lima, Igor A. Ges, David K. Schaffer, Borislav Ivanov, Andreas A. Werdich, Franz J. Baudenbacher
Publikováno v:
Biosensors and Bioelectronics. 21:248-256
Microsensors are valuable tools to monitor cell metabolism in cell culture volumes. The present research describes the fabrication and characterization of on-chip thin-film iridium oxide pH microsensors with dimensions of 20 microm x 20 microm and 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862eef62d9cdc9bf4dbf52b7134c657a
https://doi.org/10.1016/j.bios.2004.09.021
https://doi.org/10.1016/j.bios.2004.09.021
Autor:
John P. Wikswo, Dmitry A. Markov, Ronald S. Reiserer, Christina C. Marasco, Phillip C. Samson, John A. McLean, Stacy D. Sherrod, Frank E. Block, David E. Cliffel, Jennifer R. McKenzie, D. L. McLean, Kevin T. Seale, Cody R. Goodwin, David K. Schaffer
The sophistication and success of recently reported microfabricated organs-on-chips and human organ constructs have made it possible to design scaled and interconnected organ systems that may significantly augment the current drug development pipelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d3a65a369b3bb909f73c304ed1a678
https://europepmc.org/articles/PMC3696887/
https://europepmc.org/articles/PMC3696887/
Autor:
Tammy Sobolik, Matthew Rogers, John P. Wikswo, Philip C. Samson, Ann Richmond, David K. Schaffer
Publikováno v:
Cancer Research. 76:4268-4268
Microfluidic devices can offer a unique opportunity to more fully examine key factors of the tumor microenvironment that mediate metastasis. A microfluidic bioreactor was fabricated and cast in (poly)dimethylsiloxane (PDMS). Highly metastatic MDA MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f480e9764750ec5085a0021e3a759df0
https://doi.org/10.1158/1538-7445.am2016-4268
https://doi.org/10.1158/1538-7445.am2016-4268
Autor:
John P. Wikswo, Tammy Sobolik, Ann Richmond, William J. Ashby, Sam Wells, Andries Zijlstra, Yingjun Su, David K. Schaffer
Publikováno v:
IntraVital. 5:e1125562
We developed mammary imaging windows (MIWs) to evaluate leukocyte infiltration and cancer cell dissemination in mouse mammary tumors imaged by confocal microscopy. Previous techniques relied on surgical resection of a skin flap to image the tumor mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8822f9b64fa9526fc84522d492d72de
https://doi.org/10.1080/21659087.2015.1125562
https://doi.org/10.1080/21659087.2015.1125562
Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media
Autor:
Dmitry A. Markov, David K. Schaffer, John P. Wikswo, Leslie M. Shor, Philip C. Samson, Adit Dhummakupt
Microbial growth and transport in porous media have important implications for the quality of groundwater and surface water, the recycling of nutrients in the environment, as well as directly for the transmission of pathogens to drinking water suppli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6e912863b737205aa86819768df9e3
https://europepmc.org/articles/PMC3152860/
https://europepmc.org/articles/PMC3152860/
Autor:
Franz J. Baudenbacher, David K. Schaffer, Ales Prokop, John P. Wikswo, David E. Cliffel, Zdenka Prokop, Eugene Kozlov
Publikováno v:
Biomedical microdevices. 6(4)
There is a need for microminiaturized cell-culture environments, i.e. NanoLiter BioReactors (NBRs), for growing and maintaining populations of up to several hundred cultured mammalian cells in volumes three orders of magnitude smaller than those cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2c13494988df4cfae66bf375339ecb
https://pubmed.ncbi.nlm.nih.gov/15548879
https://pubmed.ncbi.nlm.nih.gov/15548879