Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David K Scoville"'
Autor:
Oscar Takeo Suzuki, Amber eFrick, Bethany B Parks, O. Joseph eTrask Jr., Natasha eButz, Brian eSteffy, Emmanuel eChan, David K Scoville, Eric eHealy, Cristina eBenton, Patricia E McQuaid, Russell S Thomas, Tim eWiltshire
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
New approaches to toxicity testing have incorporated high-throughput screening across a broad-range of in vitro assays to identify potential key events in response to chemical or drug treatment. To date, these approaches have primarily utilized repur
Externí odkaz:
https://doaj.org/article/6d46b6ef568f4b90a6a748eebc71b5a9
Autor:
Julia Tilburg, Andrew P. Stone, James M. Billingsley, David K. Scoville, Anna Pavenko, Yan Liang, Joseph E. Italiano, Kellie R. Machlus
Publikováno v:
Research and Practice in Thrombosis and Haemostasis. 7:100158
Autor:
Christopher M. Schaupp, Dianne Botta, Collin C. White, David K. Scoville, Sengkeo Srinouanprachanh, Theo K. Bammler, James MacDonald, Terrance J. Kavanagh
Publikováno v:
Redox Biology, Vol 49, Iss, Pp 102213-(2022)
Redox Biology
Redox Biology
Antioxidant signaling/communication is among the most important cellular defense and survival pathways, and the importance of redox signaling and homeostasis in aging has been well-documented. Intracellular levels of glutathione (GSH), a very importa
Autor:
Cindy Yanfei Li, Daniel Raftery, Sridhar Mani, Haiwei Gu, David K. Scoville, Joseph L. Dempsey, Julia Yue Cui, Dongfang Wang
Publikováno v:
Drug Metab Dispos
Polybrominated diphenyl ethers (PBDEs) are persistent environmental toxicants associated with increased risk for metabolic syndrome. Intermediary metabolism is influenced by the intestinal microbiome. To test the hypothesis that PBDEs reduce host-ben
Autor:
William A. Altemeier, Tomomi Workman, Elaine M. Faustman, Terrance J. Kavanagh, William K. Boyes, Tyler P Nicholas, David K. Scoville
Publikováno v:
WIREs Nanomedicine and Nanobiotechnology. 13
The Adverse Outcome Pathway (AOP) framework is serving as a basis to integrate new data streams in order to enhance the power of predictive toxicology. AOP development for engineered nanomaterials (ENM), including silver nanoparticles (AgNP), is curr
Autor:
William A. Altemeier, Dowon An, Theo K. Bammler, David K. Scoville, Xiaohu Gao, Terrance J. Kavanagh, Charles L. White, Zahra Afsharinejad, Dianne Botta
Publikováno v:
Inhalation Toxicology. 30:397-403
Concerns have been raised regarding occupational exposure to engineered nanomaterials (ENMs). Potential impacts on lung function from inhalation exposures are of concern as the lung is a sensitive ENM target in animals. Epidemiological data suggest t
Autor:
Charles W. Frevert, Zahra Afsharinejad, David K. Scoville, William A. Altemeier, Xiaohu Gao, Teal S. Hallstrand, Brian W. Johnson, Dowon An, H. Luke Ogden, James D. Nolin, Terrance J. Kavanagh, Theo K. Bammler
Publikováno v:
Toxicol Appl Pharmacol
Quantum dot nanoparticles (QDs) are engineered nanomaterials (ENMs) that have utility in many industries due to unique optical properties not available in small molecules or bulk materials. QD-induced acute lung inflammation and toxicity in rodent mo
Autor:
David K. Scoville, T.J. Kavanagh
Toxicology leverages several scientific disciplines to understand how chemical and physical agents impact living organisms. The advent of genomic technologies has advanced toxicology in several areas including the discovery of genes that modify susce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f095849ba6c2cfe129883126c8c09be
https://doi.org/10.1016/b978-0-12-801238-3.65248-0
https://doi.org/10.1016/b978-0-12-801238-3.65248-0
Autor:
Brittany A. Weldon, Elaine M. Faustman, David K. Scoville, Tomomi Workman, Terrance J. Kavanagh, William C. Griffith
Publikováno v:
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 10(4)
Engineered nanomaterials are currently under review for their potential toxicity; however, their use in consumer/commercial products has continued to outpace risk assessments. In vitro methods may be utilized as tools to improve the efficiency of ris
Autor:
David K. Scoville, Charles L. White, James W. MacDonald, Patricia L. Stapleton, Lung Chi Chen, Stefanie C. Schmuck, William A. Altemeier, Steven R. Kleeberger, Theo K. Bammler, Terrance J. Kavanagh, Dianne Botta, Michelle Hernandez, Terry Gordon, Karen Galdanes
Silver nanoparticles (AgNPs) are employed in a variety of consumer products; however, in vivo rodent studies indicate that AgNPs can cause lung inflammation and toxicity in a strain- and particle type-dependent manner, but mechanisms of susceptibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66dbc804478a05a2e53b12421984658
https://europepmc.org/articles/PMC5602892/
https://europepmc.org/articles/PMC5602892/