Výsledky vyhledávání - "David K H, Lee"

2-Substituted Tryptamines: Agents with Selectivity for 5-HT6 Serotonin Receptors

Autor: Malgorzata Dukat, Sandy Hufeisen, Laura Rauser, Bryan L. Roth, Ace McBride, Richard A. Glennon, Jagadeesh Babu Rangisetty, Jason E. Savage, Mase Lee, David K. H. Lee

Publikováno v: Journal of Medicinal Chemistry. 43:1011-1018

Several 2-alkyl-5-methoxytryptamine analogues were designed and prepared as potential 5-HT(6) serotonin agonists. It was found that 5-HT(6) receptors accommodate small alkyl substituents at the indole 2-position and that the resulting compounds can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ffac90ed2d2ef8fef7243d9ee0a477
https://doi.org/10.1021/jm990550b

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ChemInform Abstract: 2-Substituted Tryptamines: Agents with Selectivity for 5-HT6 Serotonin Receptors

Autor: Jagadeesh Babu Rangisetty, Bryan L. Roth, Jason E. Savage, Mase Lee, Malgorzata Dukat, Richard A. Glennon, Ace McBride, Sandy Hufeisen, David K. H. Lee, Laura Rauser

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::462ec2b295de7f679f140a4b30b55d66
https://doi.org/10.1002/chin.200023120

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ChemInform Abstract: 5-Thienyltryptamine Derivatives as Serotonin 5-HT1B/1D Receptor Agonists: Potential Treatments for Migraine

Autor: Lucy Mazzocco, Suman Rakhit, David K. H. Lee, Charles Q. Meng, Kerry Dyne, Kirk McCallum, Abdelmalik Slassi, Rajender Kamboj

Publikováno v: ChemInform. 31

A series of 5-(2- or 3-thienyl)tryptamine derivatives (9 Download : Download high-res image (170KB) Download : Download full-size image Scheme 1 . Reagents and conditions: (a) oxalylchloride, diethylether, 0 °C, then reflux overnight; (b) amines, tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fbbc1a19ba6b7c92413490d728ad873
https://doi.org/10.1002/chin.200036204

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5-Thienyltryptamine derivatives as serotonin 5-HT 1B/1D receptor agonists: potential treatments for migraine

Autor: Rajender Kamboj, Lucy Mazzocco, Kerry Dyne, David K. H. Lee, Suman Rakhit, Charles Q. Meng, Abdelmalik Slassi, Kirk McCallum

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:903-905

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ef2ef5b3389fad68fcf54cb7c6d599
https://doi.org/10.1016/s0960-894x(00)00133-5

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Neutrophil-derived relaxing factor relaxes vascular smooth muscle through a cGMP-mediated mechanism

Autor: D. Faunce, R.J. Sturm, Thomas J. Rimele, David K. H. Lee, D. Henry

Publikováno v: Life Sciences. 46:1531-1538

Neutrophils harvested from the peritoneal cavities of rats have been shown to release a factor that relaxes precontracted aorta and has a pharmacologic profile similar to that previously reported for endothelium-derived relaxing factor (EDRF). The pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b1e551fd2a2b909d0c94a4e9a5ec98
https://doi.org/10.1016/0024-3205(90)90426-r

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Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists

Autor: James A, Hendrix, Stephen J, Shimshock, Gregory M, Shutske, John D, Tomer, Kevin J, Kapples, Mark G, Palermo, Thomas J Roy, Corbett, Hugo M, Vargas, Sharon, Kafka, Karen M, Brooks, Lynn, Laws-Ricker, David K H, Lee, Inez, de Lannoy, Michel, Bordeleau, Geihan, Rizkalla, Joshua, Owolabi, Rajender K, Kamboj

Publikováno v: Chembiochem : a European journal of chemical biology. 3(10)

A new class of potent dopamine D(4) antagonists was discovered with selectivity over dopamine D(2) and the alpha-1 adrenoceptor. The lead compound was discovered by screening our compound collection. The structure-activity relationships of substitute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff30dd173494c1d430b6e14da77e12fa
https://pubmed.ncbi.nlm.nih.gov/12362366

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2-(1-Naphthyloxy)ethylamines with enhanced affinity for human 5-HT1D beta (h5-HT1B) serotonin receptors

Autor: Lucia Mazzocco, Ermi Fan, Milt Teitler, David K. H. Lee, Ho Law, Malgorzata Dukat, Rajender Kamboj, Myles E. Pierson, Abd M. Ismaiel, Donna Buekschkens, Richard A. Glennon

Publikováno v: Journal of medicinal chemistry. 40(26)

Although the beta-adrenergic antagonist propranolol (1) binds at rodent 5-HT1B serotonin receptors, it displays low affinity (Ki > 10,000 nM) for its species homologue 5-HT1D beta (i.e., h5-HT1B) receptors. The structure of propranolol was systematic

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https://pubmed.ncbi.nlm.nih.gov/9435911

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Effect of etodolac on the prostaglandin concentrations in the kidney of the normal rat

Autor: David K. H. Lee

Publikováno v: Drug Development Research. 9:305-311

The effect of acute and subchronic dosing with etodolac on the renal PGE2 and 6-keto-PGF1α concentrations in the normal rat were studied. Etodolac and other nonsteroidal antiinflammatory drugs (NSAIDs) were administered orally, at equieffective anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0504eb2bc386e2280b1fb3ddd3cbf049
https://doi.org/10.1002/ddr.430090408

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