Zobrazeno 1 - 10
of 42
pro vyhledávání: '"David K Flaherty"'
Autor:
Nicole A Young, David K Flaherty, David C. Airey, Feyi eAworunse, Peter A. Varlan, Jon H Kaas, Christine E Collins
Publikováno v:
Frontiers in Neuroanatomy, Vol 6 (2012)
The numbers and types of cells in an area of cortex define its function. Therefore it is essential to characterize the numbers and distributions of total cells in areas of the cortex, as well as to identify numbers of subclasses of neurons and glial
Externí odkaz:
https://doaj.org/article/457be67418ff49a086877ddba427dcff
Publikováno v:
Frontiers in Neuroanatomy, Vol 4 (2010)
It is of critical importance to understand the numbers and distributions of neurons and non-neurons in the cerebral cortex because cell numbers are reduced with normal aging and by diseases of the CNS. The isotropic fractionator method provides a fas
Externí odkaz:
https://doaj.org/article/e5c103354dbd475a9a52fbd37cf2c89f
Autor:
Ly Pham, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, Andrew Patterson, Joshua P. Fessel, Kelli L. Boyd, Jenny C. Schafer, Jamie L. Kuck, Aaron C. Shaver, David K. Flaherty, Brittany K. Matlock, Christiaan D. M. Wijers, C. Henrique Serezani, Dean P. Jones, Evan L. Brittain, Jeffrey C. Rathmell, Michael J. Noto
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.
Externí odkaz:
https://doaj.org/article/d76a7386c54d4c2f854b839fc40b5550
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 ha
Externí odkaz:
https://doaj.org/article/4970649d70db445fb70eaa8e823937b6
Autor:
Anna E. Patrick, Kayla Shoaff, Tashawna Esmond, David M. Patrick, David K. Flaherty, T Brent Graham, Philip S. Crooke, Susan Thompson, Thomas M. Aune
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In juvenile idiopathic arthritis (JIA) inflammatory T cells and their produced cytokines are drug targets and play a role in disease pathogenesis. Despite their clinical importance, the sources and types of inflammatory T cells involved remain unclea
Externí odkaz:
https://doaj.org/article/dc42e2db61734440a0adf1c18b6b5635
Autor:
Diane C. Saunders, Kristie I. Aamodt, Tiffany M. Richardson, Alexander J. Hopkirk, Radhika Aramandla, Greg Poffenberger, Regina Jenkins, David K. Flaherty, Nripesh Prasad, Shawn E. Levy, Alvin C. Powers, Marcela Brissova
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract Endogenous β cell regeneration could alleviate diabetes, but proliferative stimuli within the islet microenvironment are incompletely understood. We previously found that β cell recovery following hypervascularization-induced β cell loss
Externí odkaz:
https://doaj.org/article/9fc6488438814df2a6871457cb867bcb
Autor:
Heini M Natri, Christina B Del Azodi, Lance Peter, Chase J Taylor, Sagrika Chugh, Robert Kendle, Mei-i Chung, David K Flaherty, Brittany K Matlock, Carla L Calvi, Timothy S Blackwell, Lorraine B Ware, Matthew Bacchetta, Rajat Walia, Ciara M Shaver, Jonathan A Kropski, Davis J McCarthy, Nicholas E Banovich
Publikováno v:
bioRxiv
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis (PF). Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb33f8d2914884f147f02fc19d6ac0f
https://europepmc.org/articles/PMC10055257/
https://europepmc.org/articles/PMC10055257/
Autor:
Andrea C Florian, Chase M Woodley, Jing Wang, Brian C Grieb, Macey J Slota, Kiana Guerrazzi, Chih-Yuan Hsu, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Stephen W Fesik, Gregory C Howard, Qi Liu, April M Weissmiller, William P Tansey
Publikováno v:
NAR Cancer. 4
Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic changes including vulnerability
Autor:
Stephen W. Fesik, Dai H. Chung, William P. Tansey, David K. Flaherty, Alissa D. Guarnaccia, Eric J. Rellinger, April M. Weissmiller, Shelly L. Lorey, Brittany K. Matlock, Erin R. Aho, Chase M Woodley, Gregory C. Howard, Qi Liu, Audra F Bryan, Jing Wang
Publikováno v:
Nucleic Acids Research
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocke
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 have been d