Zobrazeno 1 - 10
of 253
pro vyhledávání: '"David K Crossman"'
Publikováno v:
BioTechniques, Vol 70, Iss 2, Pp 89-99 (2021)
IgA nephropathy (IgAN) is an autoimmune disease characterized by renal glomerular immunodeposits enriched for galactose-deficient IgA1 (Gd-IgA1; autoantigen) with the corresponding IgG autoantibodies. Despite the known contribution of Gd-IgA1 to IgAN
Externí odkaz:
https://doaj.org/article/a2c3809c5ffb4fcb9fe51fd310ea20b8
Autor:
Itika Arora, Manvi Sharma, Shizhao Li, Michael Crowley, David K Crossman, Yuanyuan Li, Trygve O Tollefsbol
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0264858 (2022)
Broccoli sprouts (BSp), a cruciferous vegetable, has shown promising effects on prevention of many types of cancer including breast cancer (BC). BC has a developmental foundation, and maternal nutrition status may influence an offspring's risk to BC
Externí odkaz:
https://doaj.org/article/9999599247544a2c95f09b6512d8c92c
Autor:
Laura V Bownes, Adele P Williams, Raoud Marayati, Colin H Quinn, Sara C Hutchins, Jerry E Stewart, Trung Vu, Juliet L Easlick, Elizabeth Mroczek-Musulman, David K Crossman, Joshua C Anderson, Christopher D Willey, Pran K Datta, Elizabeth A Beierle
Publikováno v:
Cancers, Vol 13, Iss 13, p 3201 (2021)
Background: Serine-threonine kinase receptor-associated protein (STRAP) plays an important role in neural development but also in tumor growth. Neuroblastoma, a tumor of neural crest origin, is the most common extracranial solid malignancy of childho
Externí odkaz:
https://doaj.org/article/9ae56fc48d8a4754b62b80bb08658eb8
Sharing of gut microbial strains between selected individual sets of twins cohabitating for decades.
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226111 (2019)
BACKGROUND:Given the increasing realization of the important functions of the gut microbial community in human health, it is important to determine whether the increased age of the host coupled with inevitable environmental changes can alter the stab
Externí odkaz:
https://doaj.org/article/dbadf04c28da4fe5890d8ac7028b1a84
Autor:
Piotr Madanecki, Magdalena Bałut, Patrick G Buckley, J Renata Ochocka, Rafał Bartoszewski, David K Crossman, Ludwine M Messiaen, Arkadiusz Piotrowski
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192858 (2018)
High-throughput technologies generate considerable amount of data which often requires bioinformatic expertise to analyze. Here we present High-Throughput Tabular Data Processor (HTDP), a platform independent Java program. HTDP works on any character
Externí odkaz:
https://doaj.org/article/f658580a84fd4c439d0e0746982585c7
Autor:
Cameron Church, Christian X. Fay, Emil Kriukov, Hui Liu, Ashley Cannon, Lauren Ashley Baldwin, David K. Crossman, Bruce Korf, Margaret R. Wallace, Andrea M. Gross, Brigitte C. Widemann, Robert A. Kesterson, Petr Baranov, Deeann Wallis
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Neurofibromatosis Type 1 (NF1) is caused by loss of function variants in the NF1 gene. Most patients with NF1 develop skin lesions called cutaneous neurofibromas (cNFs). Currently the only approved therapeutic for NF1 is selumetinib, a mitog
Externí odkaz:
https://doaj.org/article/d00a5353dd604d0dbaf40783a4391f24
Autor:
Wen Jiang, David K Crossman, Elizabeth H Mitchell, Philip Sohn, Michael R Crowley, Rosa Serra
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58329 (2013)
Wnt5a is a non-canonical signaling Wnt. Low expression of WNT5A is correlated with poor prognosis in breast cancer patients. The highly invasive breast cancer cell lines, MDA-MB-231 and 4T1, express very low levels of WNT5A. To determine if enhanced
Externí odkaz:
https://doaj.org/article/00b012251be9447989af5cd35c5e8c8f
Autor:
Cyntanna C. Hawkins, Amber B. Jones, Emily R. Gordon, Yuvika Harsh, Julia K. Ziebro, Christopher D. Willey, Corinne Griguer, David K. Crossman, Sara J. Cooper, Sasanka Ramanadham, Ninh Doan, Anita B. Hjelmeland
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Sphingolipid metabolism is dysregulated in many cancers, allowing cells to evade apoptosis through increased sphingosine-1-phosphate (S1P) and decreased ceramides. Ceramidases hydrolyze ceramides to sphingosine, which is phosphorylated by sp
Externí odkaz:
https://doaj.org/article/968cfb928d054a14a0cfa5059517fa60
Autor:
Lan Wang, Mark E Clark, David K Crossman, Kyoko Kojima, Jeffrey D Messinger, James A Mobley, Christine A Curcio
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10329 (2010)
Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in
Externí odkaz:
https://doaj.org/article/a92ed5ba3a024591b0c57fe13eedc561
Autor:
Amit Singh, David K Crossman, Deborah Mai, Loni Guidry, Martin I Voskuil, Matthew B Renfrow, Adrie J C Steyn
Publikováno v:
PLoS Pathogens, Vol 5, Iss 8, p e1000545 (2009)
The metabolic events associated with maintaining redox homeostasis in Mycobacterium tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel redox switching mechanism by which Mtb WhiB3 under defined oxidizing and reduci
Externí odkaz:
https://doaj.org/article/bd5a30f329df4ff6bfce98bb7332f434