Zobrazeno 1 - 10
of 359
pro vyhledávání: '"David K Crossman"'
Autor:
Cameron Church, Christian X. Fay, Emil Kriukov, Hui Liu, Ashley Cannon, Lauren Ashley Baldwin, David K. Crossman, Bruce Korf, Margaret R. Wallace, Andrea M. Gross, Brigitte C. Widemann, Robert A. Kesterson, Petr Baranov, Deeann Wallis
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Neurofibromatosis Type 1 (NF1) is caused by loss of function variants in the NF1 gene. Most patients with NF1 develop skin lesions called cutaneous neurofibromas (cNFs). Currently the only approved therapeutic for NF1 is selumetinib, a mitog
Externí odkaz:
https://doaj.org/article/d00a5353dd604d0dbaf40783a4391f24
Autor:
Cyntanna C. Hawkins, Amber B. Jones, Emily R. Gordon, Yuvika Harsh, Julia K. Ziebro, Christopher D. Willey, Corinne Griguer, David K. Crossman, Sara J. Cooper, Sasanka Ramanadham, Ninh Doan, Anita B. Hjelmeland
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Sphingolipid metabolism is dysregulated in many cancers, allowing cells to evade apoptosis through increased sphingosine-1-phosphate (S1P) and decreased ceramides. Ceramidases hydrolyze ceramides to sphingosine, which is phosphorylated by sp
Externí odkaz:
https://doaj.org/article/968cfb928d054a14a0cfa5059517fa60
Autor:
Purnima Singh, Liting Zhou, Disheet A. Shah, Romina B. Cejas, David K. Crossman, Mariam Jouni, Tarek Magdy, Xuexia Wang, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Steve Horvath, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A. Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Paul W. Burridge, Smita Bhatia
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Anthracycline-induced cardiomyopathy is a leading cause of late morbidity in childhood cancer survivors. Aberrant DNA methylation plays a role in de novo cardiovascular disease. Epigenetic processes could play a role in anthracycline-induced
Externí odkaz:
https://doaj.org/article/5acaf1b97f694d69939aaf30a6003783
Autor:
Radomir M. Slominski, Tae-Kang Kim, Zorica Janjetovic, Anna A. Brożyna, Ewa Podgorska, Katie M. Dixon, Rebecca S. Mason, Robert C. Tuckey, Rahul Sharma, David K. Crossman, Craig Elmets, Chander Raman, Anton M. Jetten, Arup K. Indra, Andrzej T. Slominski
Publikováno v:
Cancers, Vol 16, Iss 12, p 2262 (2024)
Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and a high mortality rate. This review disc
Externí odkaz:
https://doaj.org/article/b60ae2d1867c466793431795178c02bc
Autor:
Parveen Kumar, Emma Laurence, David K. Crossman, Dean G. Assimos, Michael P. Murphy, Tanecia Mitchell
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102919- (2023)
Oxalate is a small compound found in certain plant-derived foods and is a major component of calcium oxalate (CaOx) kidney stones. Individuals that consume oxalate enriched meals have an increased risk of forming urinary crystals, which are precursor
Externí odkaz:
https://doaj.org/article/289edf26892c42eb80fcee58347acb6e
Autor:
Nikita Bhalerao, Asmi Chakraborty, Michael P. Marciel, Jihye Hwang, Colleen M. Britain, Austin D. Silva, Isam E. Eltoum, Robert B. Jones, Katie L. Alexander, Lesley E. Smythies, Phillip D. Smith, David K. Crossman, Michael R. Crowley, Boyoung Shin, Laurie E. Harrington, Zhaoqi Yan, Maigen M. Bethea, Chad S. Hunter, Christopher A. Klug, Donald J. Buchsbaum, Susan L. Bellis
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area of research. In this study, we determined that ST6 β-galactoside α2,6 sialyltransferase 1 (ST6GAL1), which adds α2,6-linked sialic aci
Externí odkaz:
https://doaj.org/article/8d74b6365a7e4f5aab8310300004ced9
Autor:
Purnima Singh, Disheet A. Shah, Mariam Jouni, Romina B. Cejas, David K. Crossman, Tarek Magdy, Shaowei Qiu, Xuexia Wang, Liting Zhou, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Ravi Bhatia, Paul W. Burridge, Smita Bhatia
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Anthracycline‐induced cardiomyopathy is a leading cause of premature death in childhood cancer survivors, presenting a need to understand the underlying pathogenesis. We sought to examine differential blood‐based mRNA expression profil
Externí odkaz:
https://doaj.org/article/f8f46a7b0c144ebca9495b274983c0e1
Autor:
Alan Umfress, Ayanabha Chakraborti, Suma Priya Sudarsana Devi, Raegan Adams, Daniel Epstein, Adriana Massicano, Anna Sorace, Sarbjit Singh, M. Iqbal Hossian, Shaida A. Andrabi, David K. Crossman, Nilesh Kumar, M. Shahid Mukhtar, Huiyang Luo, Claire Simpson, Kathryn Abell, Matthew Stokes, Thorsten Wiederhold, Charles Rosen, Hongbing Lu, Amarnath Natarajan, James A. Bibb
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Millions of traumatic brain injuries (TBIs) occur annually. TBIs commonly result from falls, traffic accidents, and sports-related injuries, all of which involve rotational acceleration/deceleration of the brain. During these injuries, the b
Externí odkaz:
https://doaj.org/article/4ad206824ca1456fbf9e80bcb898365c
Autor:
Matthew J. Sullivan, Darren Prince, Kelvin G. K. Goh, Lahiru Katupitiya, Dean Gosling, Michael R. Crowley, David K. Crossman, Glen C. Ulett
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Streptococcus agalactiae, also known as Group B Streptococcus (GBS) is a frequent cause of infections, including bacteraemia and other acute diseases in adults and immunocompromised individuals. We developed a novel system to study GBS withi
Externí odkaz:
https://doaj.org/article/ba104a9df20644099df98bfad98b3b28
Autor:
Randee Sedaka, Jifeng Huang, Shinobu Yamaguchi, Caleb Lovelady, Jung-Shan Hsu, Sejal Shinde, Malgorzata Kasztan, David K. Crossman, Takamitsu Saigusa
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundDisease severity of autosomal dominant polycystic kidney disease (ADPKD) is influenced by diet. Dietary protein, a recognized cyst-accelerating factor, is catabolized into amino acids (AA) and delivered to the kidney leading to renal hypert
Externí odkaz:
https://doaj.org/article/a83cfa831b3b408c9dda93a8ccb1a86d