Zobrazeno 1 - 10
of 29
pro vyhledávání: '"David Kägi"'
Autor:
Tak W. Mak, Wen-Chen Yeh, David Kägi, Alexia Williams, Christine Mirtsos, Matthew Moyle, Annick Itié, Ursula Kapp, Bruce Patterson, Mike Tipsword, Andrew J. Elia, Andrew Hessel, Alexandra Ho
Publikováno v:
The Journal of Experimental Medicine
Gene expression patterns can provide vital clues to the pathogenesis of neoplastic diseases. We investigated the expression of 950 genes in Hodgkin's disease (HD) by analyzing differential mRNA expression using microarrays. In two independent microar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db0655cd60acca2798aa491a7bd55a1
http://europepmc.org/articles/PMC2192965
http://europepmc.org/articles/PMC2192965
Autor:
José Luis de la Pompa, Ritsuko Yoshida, David Kägi, Andrew E. H. Elia, Razqallah Hakem, Stephen Kaufman, Minna Woo, Julia Potter, Wilson Khoo, Josef M. Penninger, Anne Hakem, Tak W. Mak, Maria S. Soengas, Gordon S. Duncan, Jeffrey T. Henderson, Scott W. Lowe
Publikováno v:
Cell. 94(3):339-352
Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis. Casp9 −/− embryonic stem cells and embryonic fibroblasts are resistant to several apoptotic stimuli, including UV an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7faa4991220e107e46e538ce71b67d0b
Autor:
David Kägi, Maries van den Broek, Rolf M. Zinkernagel, Jörg Fehr, Daniel Binder, Horst Bluethmann, Hans Hengartner
Publikováno v:
The Journal of Experimental Medicine
Aplastic anemia may be associated with persistent viral infections that result from failure of the immune system to control virus. To evaluate the effects on hematopoiesis exerted by sustained viral replication in the presence of activated T cells, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3f906da66c9e0d0d0615002c362cd3
https://doi.org/10.1084/jem.187.11.1903
https://doi.org/10.1084/jem.187.11.1903
Publikováno v:
Journal of Virology. 72:4515-4519
Theiler’s virus, a murine picornavirus, infects the central nervous systems of C57BL/6 mice and is cleared after approximately 10 days by a process which requires CD8 + cytotoxic T cells. We used perforin-deficient C57BL/6 mice to test the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6c070b63cb2d41ca0b19a6c1d591ce
https://doi.org/10.1128/jvi.72.5.4515-4519.1998
https://doi.org/10.1128/jvi.72.5.4515-4519.1998
Autor:
Razqallah Hakem, Tak W. Mak, Arda Shahinian, Giorgio Senaldi, Stephen Kaufman, Tamara Howard, Mila E. McCurrach, Minna Woo, Anne Hakem, Maria S. Soengas, Wilson Khoo, Scott W. Lowe, David Kägi, Gordon S. Duncan
Publikováno v:
Genes & Development. 12:806-819
Caspases are fundamental components of the mammalian apoptotic machinery, but the precise contribution of individual caspases is controversial. CPP32 (caspase 3) is a prototypical caspase that becomes activated during apoptosis. In this study, we too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923ee55fa2697cce78f49e8be3685abf
https://doi.org/10.1101/gad.12.6.806
https://doi.org/10.1101/gad.12.6.806
Publikováno v:
Placenta. 19:143-150
Summary Perforin is a cytotoxic molecule which is found in high concentration at the fetomaternal interface. In this location, perforin is contained in a specialized subset of natural killer cells, called uterine NK cells. By the use of perforin-defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e83ec52655c95c0b8b7ed27a9d05f5a
https://doi.org/10.1016/s0143-4004(98)80039-8
https://doi.org/10.1016/s0143-4004(98)80039-8
Autor:
Bernhard Odermatt, Hans Hengartner, David Kägi, Peter Seiler, Rolf M. Zinkernagel, Tak W. Mak
Publikováno v:
The Journal of Experimental Medicine
To investigate the role of T cell–mediated, perforin-dependent cytotoxicity in autoimmune diabetes, perforin-deficient mice were backcrossed with the nonobese diabetes mouse strain. It was found that the incidence of spontaneous diabetes over a 1 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0922ba53023a7a2fe2623e46540e86de
https://doi.org/10.1084/jem.186.7.989
https://doi.org/10.1084/jem.186.7.989
Publikováno v:
The Journal of Experimental Medicine
The activation of natural killer (NK) cells, cytotoxic lymphocytes capable of major histocompatibility complex (MHC)-unrestricted killing and early antiviral defense, is temporally related to the increased interferon (IFN)-alpha/beta production that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20fb4ccb80f6dbaf8a5220b192d7903
https://doi.org/10.1084/jem.184.5.2043
https://doi.org/10.1084/jem.184.5.2043
Autor:
Hans Hengartner, David Kägi
Publikováno v:
Current Opinion in Immunology. 8:472-477
The assessment of the role of T-cell-mediated cytotoxicity in immunity to viral infections has been difficult to address directly and therefore has been controversial. Recent experiments with perforin-deficient mice have shown that cytotoxicity is cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4208fc4e9762633a0175e5bcad1d5a85
https://doi.org/10.1016/s0952-7915(96)80033-1
https://doi.org/10.1016/s0952-7915(96)80033-1
Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity
Publikováno v:
The Journal of Experimental Medicine
It is widely accepted that T cells play an important role in the destruction of beta cells leading to autoimmune type I diabetes, but the involved effector mechanisms have remained unclear. We addressed this issue by testing the role of perforin-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a84f6b6bbad9c6151afc4332ee679c
http://europepmc.org/articles/PMC2192591
http://europepmc.org/articles/PMC2192591