Zobrazeno 1 - 10
of 359
pro vyhledávání: '"David K, Meyerholz"'
Autor:
Gang Wang, Abhishek K. Verma, Juan Shi, Xiaoqing Guan, David K. Meyerholz, Fan Bu, Wei Wen, Bin Liu, Fang Li, Stanley Perlman, Lanying Du
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Although Omicron RBD of SARS-CoV-2 accumulates many mutations, the backbone region (truncated RBD) of spike protein is highly conserved. Here, we designed several subunit vaccines by keeping the conserved spike backbone region of SARS-CoV-2
Externí odkaz:
https://doaj.org/article/0e852fcffc6f4ff1b5c6ecac08e229e4
Autor:
Christopher Zdyrski, Vojtech Gabriel, Thea B. Gessler, Abigail Ralston, Itzel Sifuentes-Romero, Debosmita Kundu, Sydney Honold, Hannah Wickham, Nicholas E. Topping, Dipak Kumar Sahoo, Basanta Bista, Jeffrey Tamplin, Oscar Ospina, Pablo Piñeyro, Marco Arriaga, Jacob A. Galan, David K. Meyerholz, Karin Allenspach, Jonathan P. Mochel, Nicole Valenzuela
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Painted turtles are remarkable for their freeze tolerance and supercooling ability along with their associated resilience to hypoxia/anoxia and oxidative stress, rendering them an ideal biomedical model for hypoxia-induced injuries (includin
Externí odkaz:
https://doaj.org/article/531fb488b91342cbb3698ef755cb2111
Autor:
Vicki J. Swier, Katherine A. White, Pedro L. Negrão de Assis, Tyler B. Johnson, Hannah G. Leppert, Mitchell J. Rechtzigel, David K. Meyerholz, Rebecca D. Dodd, Dawn E. Quelle, Rajesh Khanna, Christopher S. Rogers, Jill M. Weimer
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract Cognitive or motor impairment is common among individuals with neurofibromatosis type 1 (NF1), an autosomal dominant tumor‐predisposition disorder. As many as 70% of children with NF1 report difficulties with spatial/working memory, attent
Externí odkaz:
https://doaj.org/article/dcb502b067bb4af5b36833c1c551cbde
Autor:
Gopinathan Gangadharan Nambiar, Sussette Gonzalez Szachowicz, Christian F. Zirbes, Jared J. Hill, Linda S. Powers, David K. Meyerholz, Ian M. Thornell, David A. Stoltz, Anthony J. Fischer
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionMeconium ileus (MI) is a life-threatening obstruction of the intestines affecting ∼15% of newborns with cystic fibrosis (CF). Current medical treatments for MI often fail, requiring surgical intervention. MI typically occurs in newborns
Externí odkaz:
https://doaj.org/article/1b4483c0066844d2a9383238af8cf27f
Autor:
Abigail R. Gress, Christine E. Ronayne, Joshua M. Thiede, David K. Meyerholz, Samuel Okurut, Julia Stumpf, Tailor V. Mathes, Kenneth Ssebambulidde, David B. Meya, Fiona V. Cresswell, David R. Boulware, Tyler D. Bold
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract After Mycobacterium tuberculosis (Mtb) infection, many effector T cells traffic to the lungs, but few become activated. Here we use an antigen receptor reporter mouse (Nur77-GFP) to identify recently activated CD4 T cells in the lungs. These
Externí odkaz:
https://doaj.org/article/ca259876e3be47d9b437b62b4a3c7cd7
Autor:
Katarina Kulhankova, Soumba Traore, Xue Cheng, Hadrien Benk-Fortin, Stéphanie Hallée, Mario Harvey, Joannie Roberge, Frédéric Couture, Sajeev Kohli, Thomas J. Gross, David K. Meyerholz, Garrett R. Rettig, Bernice Thommandru, Gavin Kurgan, Christine Wohlford-Lenane, Dennis J. Hartigan-O’Connor, Bradley P. Yates, Gregory A. Newby, David R. Liu, Alice F. Tarantal, David Guay, Paul B. McCray
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Gene editing strategies for cystic fibrosis are challenged by the complex barrier properties of airway epithelia. We previously reported that the amphiphilic S10 shuttle peptide non-covalently combined with CRISPR-associated (Cas) ribonucleo
Externí odkaz:
https://doaj.org/article/8ac54f1857804245a0069d9ef38b1f91
Autor:
Pengfei Li, Yunjeong Kim, Chamandi S. Dampalla, Harry Nhat Nguyen, David K. Meyerholz, David K. Johnson, Scott Lovell, William C. Groutas, Stanley Perlman, Kyeong-Ok Chang
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic betacoronaviruses that continue to have a significant impact on public health. Timely development and intro
Externí odkaz:
https://doaj.org/article/f79fb18ff28149f79f0191d924e8bd47
Autor:
David K. Meyerholz, Mariah R. Leidinger, J. Adam Goeken, Thomas R. Businga, Sebastian Vizuett, Allison Akers, Idil Evans, Yan Zhang, John F. Engelhardt
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Objective Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5A
Externí odkaz:
https://doaj.org/article/174b53258e0b4b63aa26194e516729bd
Autor:
Lok-Yin Roy Wong, Abby Odle, Emma Luhmann, Douglas C. Wu, Yiquan Wang, Qi Wen Teo, Celeste Ptak, Alan Sariol, Shea Lowery, Matthias Mack, David K. Meyerholz, Nicholas C. Wu, Lilliana Radoshevich, Stanley Perlman
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTBetacoronaviruses encode an internal (I) gene via an alternative reading frame within the nucleocapsid gene, called ORF8b for Middle-East respiratory syndrome coronavirus (MERS-CoV) and ORF9b for severe acute respiratory syndrome coronavirus
Externí odkaz:
https://doaj.org/article/bd62f9784b1f4545831769ae31415936
Autor:
Lei Lei, Soumba Traore, Guillermo S. Romano Ibarra, Philip H. Karp, Tayyab Rehman, David K. Meyerholz, Joseph Zabner, David A. Stoltz, Patrick L. Sinn, Michael J. Welsh, Paul B. McCray Jr., Ian M. Thornell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
The volume and composition of a thin layer of liquid covering the airway surface defend the lung from inhaled pathogens and debris. Airway epithelia secrete Cl– into the airway surface liquid through cystic fibrosis transmembrane conductance regula
Externí odkaz:
https://doaj.org/article/2cd2777105f44a3382766c3e36dc6f28