Zobrazeno 1 - 10 of 10 pro vyhledávání: '"David John Hughes"'
1
Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance
Autor: Melissa Brazier-Hicks, Maria Schwarz, Glynn Mitchell, Robert Edwards, Ian Cummins, David J. Wortley, Patrick G. Steel, Hannah E. Straker, David John Hughes, Rebecca Florence Mary Eno, Christopher R. Coxon, Ehmke Pohl, Jenny Moore, Nawaporn Onkokesung, Stefanie Freitag-Pohl
Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2021, Vol.19(42), pp.9211-9222 [Peer Reviewed Journal]
Schwarz, M, Eno, R F M, Freitag-Pohl, S, Coxon, C R, Straker, H E, Wortley, D J, Hughes, D J, Mitchell, G, Moore, J, Cummins, I, Onkokesung, N, Brazier-Hicks, M, Edwards, R, Pohl, E & Steel, P G 2021, ' Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance ', Organic and Biomolecular Chemistry, vol. 19, no. 42, pp. 9211-9222 . https://doi.org/10.1039/d1ob01802g
The evolution and growth of multiple-herbicide resistance (MHR) in grass weeds continues to threaten global cereal production. While various processes can contribute to resistance, earlier work has identified the phi class glutathione-S-transferase (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8051da3d36f1de2ecdfeeb4677109416
https://doi.org/10.1039/d1ob01802g
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2
Diastereocontrolled Strecker reaction using (S)-5-phenylmorpholin-2-one
Autor: David John Hughes, Laurence M. Harwood, Richard Vickers, Michael G. B. Drew
Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :1581-1583
Iminium ions derived from (S)-5-phenylmorpholin-2-one 1 undergo diastereoselective Strecker reactions using copper(I) cyanide and anhydrous hydrochloric acid; the major adducts may be degraded to D-α-amino acids.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d89420d0a8654112bbf8c99391f5b3
https://doi.org/10.1039/b104052a
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3
ChemInform Abstract: On the Scope of Acylnitrilium Ion Initiated Heteroannulations: Monocyclizations Terminated by Unactivated Alkenes
Autor: Tom Livinghouse, David John Hughes
Publikováno v: ChemInform. 27
Intramolecular trapping of transient acylnitrilium ions by di- and tri-substituted alkenes has been shown to occur with reasonable efficiency to provide the corresponding 2,3,4,5-tetrahydropyridine and 3,4-dihydro-2H-pyrrole derivatives in moderate o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b1c59cb8d1b1f121d5bb4193e533696
https://doi.org/10.1002/chin.199604071
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4
ChemInform Abstract: Diastereocontrolled Strecker Reaction Using (S)-5-Phenylmorpholin-2-one
Autor: Richard Vickers, David John Hughes, Michael G. B. Drew, Laurence M. Harwood
Publikováno v: ChemInform. 32
Iminium ions derived from (S)-5-phenylmorpholin-2-one 1 undergo diastereoselective Strecker reactions using copper(I) cyanide and anhydrous hydrochloric acid; the major adducts may be degraded to D-α-amino acids.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00e472bb637c0daf7a10230d2d60a91f
https://doi.org/10.1002/chin.200146157
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6
Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium
Autor: Muhammad Usman Rashid, Isabel Dos Santos Silva, Sabapathy prakash Balasubramanian, Wei-Yu Lin, Angela Cox, Daehee Kang, Malcolm Reed, David John Hughes
Publikováno v: Journal of the National Cancer Institute. 98(19)
Background: The Breast Cancer Association Consortium (BCAC) is an international collaboration that was established to provide large sample sizes for examining genetic associations. We conducted combined analyses on all single-nucleotide polymorphisms
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b1f7b9c1cf0c63cc89fc7bf80fad1e
https://pubmed.ncbi.nlm.nih.gov/17374839
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7
Modular control of lectin function: redox-switchable agglutination
Autor: Benjamin G. Davis, David John Hughes, Rhona E. McDonald
Publikováno v: Angewandte Chemie (International ed. in English). 43(23)
[*] R. E. McDonald, Dr. B. G. Davis Dyson Perrins Laboratory Department of Chemistry, University of Oxford South Parks Road, Oxford, OX1 3QY (UK) Fax: (+44)1865-275-674 E-mail: ben.davis@chem.ox.ac.uk Dr. D. J. Hughes Syngenta Jealott's Hill Internat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcbe58ba69a77bbf6b0052ab0bdad67
http://ora.ox.ac.uk/objects/uuid:a2115d85-42cb-40a0-92d5-4e8cd489d717
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9
Synthesis of glucose derivatives modified at the 4-OH as potential chain-terminators of cellulose biosynthesis; herbicidal activity of simple monosaccharide derivatives
Autor: Brendan L. Wilkinson, David John Hughes, Ramona Danac, Emma van Dijkum, Richard Wood, Anne Mary Rees, Antony J. Fairbanks
Publikováno v: Organic & Biomolecular Chemistry. 7:1097
A series of D-glucose derivatives that have been modified at C-4 were synthesised from D-galactose as potential chain terminators of cellulose biosynthesis. Two compounds displayed herbicidal activity in pre-emergence tests and in addition a cell exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745453d93b6f6757b211b80db997c634
https://doi.org/10.1039/b820830a
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