A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

Autor: Mireia Montaner, Jessica Denom, Vincent Simon, Wanqing Jiang, Marie K. Holt, Daniel I. Brierley, Claude Rouch, Ewout Foppen, Nadim Kassis, David Jarriault, Dawood Khan, Louise Eygret, Francois Mifsud, David J. Hodson, Johannes Broichhagen, Lukas Van Oudenhove, Xavier Fioramonti, Victor Gault, Daniela Cota, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne-Li, Stefan Trapp, Hirac Gurden, Christophe Magnan

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and holds significant pharmacological potential. Nevertheless, the regulation of energy homeostasis by centrally-produced GLP-1 remains partially understood. Preproglucagon cells,

Externí odkaz: https://doaj.org/article/cb3515a89fa242b4a3b002d0b2c03c19

The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.

Autor: Fabrice Neiers, David Jarriault, Franck Menetrier, Loïc Briand, Jean-Marie Heydel

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0249029 (2021)

Odorant metabolizing enzymes (OMEs) are expressed in the olfactory epithelium (OE) where they play a significant role in the peripheral olfactory process by catalyzing the fast biotransformation of odorants leading either to their elimination or to t

Externí odkaz: https://doaj.org/article/1fbdc202353440da8a6c8a491d7967df

Heterogeneity and convergence of olfactory first-order neurons account for the high speed and sensitivity of second-order neurons.

Autor: Jean-Pierre Rospars, Alexandre Grémiaux, David Jarriault, Antoine Chaffiol, Christelle Monsempes, Nina Deisig, Sylvia Anton, Philippe Lucas, Dominique Martinez

Publikováno v: PLoS Computational Biology, Vol 10, Iss 12, p e1003975 (2014)

In the olfactory system of male moths, a specialized subset of neurons detects and processes the main component of the sex pheromone emitted by females. It is composed of several thousand first-order olfactory receptor neurons (ORNs), all expressing

Externí odkaz: https://doaj.org/article/8602b1ae6c4942bd8efc3729c495a424

Perinatal exposure to diets with different n-6:n-3 fatty acid ratios affects olfactory tissue fatty acid composition

Autor: Stéphane Grégoire, Niyazi Acar, Anne Marie Le Bon, Laetitia Merle, Olivier Berdeaux, Spiro Khoury, Vanessa Soubeyre, Xavier Grosmaitre, Nicolas Deprêtre, Stéphanie Cabaret, David Jarriault, Lionel Bretillon

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.10785. ⟨10.1038/s41598-020-67725-9⟩

The olfactory mucosa (OM) and the olfactory bulb (OB) are responsible for the detection and processing of olfactory signals. Like the brain and retina, they contain high levels of n-3 and n-6 polyunsaturated fatty acids (PUFAs), which are essential f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298b9d82949b91bbf5a84270f84cb3b7
http://link.springer.com/article/10.1038/s41598-020-67725-9

Maternal high fat high sugar diet disrupts olfactory behavior but not mucosa sensitivity in the offspring

Autor: Pierre Bonnet, Xavier Grosmaitre, Stéphane Grégoire, Ophélie Person, Vanessa Soubeyre, Laetitia Merle, David Jarriault

Publikováno v: Psychoneuroendocrinology (104), 249-258. (2019)
Psychoneuroendocrinology
Psychoneuroendocrinology, Elsevier, 2019, 104, pp.249-258. ⟨10.1016/j.psyneuen.2019.02.005⟩

International audience; The influence of maternal diet on progeny’s metabolic health has been thoroughly investigated, but the impact on sensory systems remains unexplored. Neurons of the olfactory system start to develop during the embryonic life

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28685c7684a0b0f934be684dfd7a1d63
http://prodinra.inra.fr/record/461078