Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David James Haddon"'
Autor:
Vivian K. Diep, Gloria Yiu, David James Haddon, Paul J. Utz, James D. Faix, Lawrence Steinman, Stephanie Tangsombatvisit, Winston A. Haynes, Alvina D. Chu, Bahareh Ajami, Tue Kruse Rasmussen
Publikováno v:
Arthritis & Rheumatology.
Objective Type I interferon (IFN) signaling is a central pathogenic pathway in systemic lupus erythematosus (SLE), and therapeutics targeting type I IFN signaling are in development. Multiple proteins with overlapping functions play a role in IFN sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cadda23eb0ea174e81bfb2c986cbafbf
https://doi.org/10.1002/art.39535
https://doi.org/10.1002/art.39535
Autor:
Justin A. Jarrell, Vivian K. Diep, Sally Mackey, Chih Long Liu, Jordan V. Price, Emily C. Baechler, Stephanie Tangsombatvisit, Paul J. Utz, Hannah Wand, Madoo Varma, David James Haddon, Grace M. Credo, Cornelia L. Dekker
The mechanisms underlying development of ribonucleoprotein (RNP) autoantibodies are unclear. The U1-70K protein is the predominant target of RNP autoantibodies, and the RNA binding domain has been shown to be the immunodominant autoantigenic region o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86cb861cb0d3f3565feaf526a17c3b8
https://europepmc.org/articles/PMC4815922/
https://europepmc.org/articles/PMC4815922/
Autor:
Lorinda Chung, Paul J. Utz, David Fiorentino, Eliza F. Chakravarty, Justin A. Jarrell, David James Haddon, Tammara A. Wood, Mark C. Genovese, Viktor Martyanov, Michael L. Whitfield
Publikováno v:
Arthritis Research & Therapy
Introduction Systemic sclerosis is an autoimmune disease characterized by inflammation and fibrosis of the skin and internal organs. We sought to assess the clinical and molecular effects associated with response to intravenous abatacept in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39f787a7d38f3f99ad778bb1133376e
https://doi.org/10.1186/s13075-015-0669-3
https://doi.org/10.1186/s13075-015-0669-3
Autor:
Anthony K. Shum, Jordan V. Price, David James Haddon, Gil Mandelbaum, Guillaume Delepine, Mickie H. Cheng, Justin A. Jarrell, Paul J. Utz, Emily C. Baechler, William H. Robinson, Jeremy Sokolove, Dodge Kemmer, Eliza F. Chakravarty, Rohit Gupta, Sarah K. Browne, Mark S. Anderson, Imelda Balboni, Steven M. Holland
Publikováno v:
The Journal of clinical investigation, vol 123, iss 12
Autoantibodies against cytokines, chemokines, and growth factors inhibit normal immunity and are implicated in inflammatory autoimmune disease and diseases of immune deficiency. In an effort to evaluate serum from autoimmune and immunodeficient patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bd87cbf8bc4e266ed8690fa77fe977
https://europepmc.org/articles/PMC3859403/
https://europepmc.org/articles/PMC3859403/
Autor:
David James Haddon, Frann Antignano, Michael R Hughes, Marie-Renée Blanchet, Lori Zbytnuik, Gerald Krystal, Kelly Marshall McNagny
Publikováno v:
The Journal of Immunology. 182:139.12-139.12
Src homology 2-containing inositol 5'-phosphatase (SHIP) inhibits immune receptor signaling through hydrolysis of the phosphatidylinositol-3 kinase (PI3K) product PI-3,4,5-P3, forming PI-3,4-P2. SHIP represses FcεRI- and cytokine-mediated mast cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88cc67016bb280cf58bde141f168e175
https://doi.org/10.4049/jimmunol.182.supp.139.12
https://doi.org/10.4049/jimmunol.182.supp.139.12