Zobrazeno 1 - 10
of 11
pro vyhledávání: '"David Jakab"'
Autor:
Nathan Eaton, Saravanan Subramaniam, Sandra L. Haberichter, David Jakab, Hervé Falet, Caleb Drew, Marie L. Schulte, Hartmut Weiler
Publikováno v:
Blood Adv
The tyrosine kinase JAK2 is a critical component of intracellular JAK/STAT cytokine signaling cascades that is prevalent in hematopoietic cells such as hematopoietic stem and progenitor cells (HSPCs), megakaryocytes (MKs), and platelets. Individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4751e84f6d7bb24cb65fb09139d10eb8
https://pubmed.ncbi.nlm.nih.gov/34342643
https://pubmed.ncbi.nlm.nih.gov/34342643
Autor:
David Jakab, A. L. Gehrand, Sachiko Kanaji, Paula M. Jacobi, J. M. Johnsen, Sandra L. Haberichter
Publikováno v:
Journal of Thrombosis and Haemostasis. 16:546-554
Essentials Reduced survival of von Willebrand factor (VWF) in plasma causes type 1C von Willebrand disease. Blood was collected from mouse strains by various methods and VWF propeptide and antigen assayed. VWF propeptide to antigen ratio identifies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fee41e9553b04b9211b68919c7b5962
https://doi.org/10.1111/jth.13934
https://doi.org/10.1111/jth.13934
Autor:
Joga Chaganti, Govinda Poudel, Lucette Adeline Cysique, Gregory J. Dore, Anthony Kelleher, Gael Matthews, David Darley, Anthony Byrne, David Jakabek, Xin Zhang, Marrissa Lewis, Nikhil Jha, Bruce James Brew
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
ObjectiveTo investigate the association between blood–brain barrier permeability, brain metabolites, microstructural integrity of the white matter, and cognitive impairment (CI) in post-acute sequelae of SARS-COV-2 infection (PASC).MethodsIn this m
Externí odkaz:
https://doaj.org/article/ac8a18f11bd2428d8a29cd0836d231ea
Autor:
Lucette A. Cysique, David Jakabek, Sophia G. Bracken, Yasmin Allen‐Davidian, Benjamin Heng, Sharron Chow, Mona Dehhaghi, Ananda Staats Pires, David R. Darley, Anthony Byrne, Chansavath Phetsouphanh, Anthony Kelleher, Gregory J. Dore, Gail V. Matthews, Gilles J. Guillemin, Bruce J. Brew
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 8, Pp 1338-1352 (2023)
Abstract Objective To determine the prevalence and natural history of post‐acute COVID‐19 objective cognitive impairment and function, and their relationship to demographic, clinical factors, post‐acute sequelae of COVID‐19 (PASC), and biomar
Externí odkaz:
https://doaj.org/article/5fb7a7f211214565bb42accae1ff9918
Autor:
David Jakabek, Brian D. Power, Nicola Spotorno, Matthew D. Macfarlane, Mark Walterfang, Dennis Velakoulis, Christer Nilsson, Maria Landqvist Waldö, Jimmy Lätt, Markus Nilsson, Danielle van Westen, Olof Lindberg, Jeffrey C.L. Looi, Alexander F. Santillo
Publikováno v:
NeuroImage: Clinical, Vol 39, Iss , Pp 103471- (2023)
Background: Using multi-block methods we combined multimodal neuroimaging metrics of thalamic morphology, thalamic white matter tract diffusion metrics, and cortical thickness to examine changes in behavioural variant frontotemporal dementia. (bvFTD)
Externí odkaz:
https://doaj.org/article/071fdbd174eb49e4bde8c4450a5258eb
Autor:
Sandra L. Haberichter, Robert R. Montgomery, Azza Abdelaal, David Jakab, Pamela A. Christopherson
Publikováno v:
Blood. 128:1398-1398
von Willebrand Disease (VWD) is the most prevalent inherited bleeding disorder. Type 1 is the most common form of VWD and results in a partial quantitative deficiency of von Willebrand Factor (VWF). The mechanisms underlying type 1 VWD are still not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b148465af5cee30acc69d835f6a49b
https://doi.org/10.1182/blood.v128.22.1398.1398
https://doi.org/10.1182/blood.v128.22.1398.1398
Autor:
Joan Cox Gill, Sandra L. Haberichter, Paula M. Jacobi, Kenneth D. Friedman, Veronica H. Flood, David Jakab
Publikováno v:
Blood. 119(19)
Type 2A VWD is characterized by the absence of large VWF multimers and decreased platelet-binding function. Historically, type 2A variants are subdivided into group 1, which have impaired assembly and secretion of VWF multimers, or group 2, which hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf044e5f27d7db800e5a5e470449634f
https://pubmed.ncbi.nlm.nih.gov/22431572
https://pubmed.ncbi.nlm.nih.gov/22431572
Publikováno v:
Blood. 122:3571-3571
One mechanism causing type 1 VWD is the reduced survival of VWF in plasma (type 1C VWD), characterized by markedly decreased VWF:Ag and VWF half-life, essentially normal multimers, increased ratio of VWF propeptide (VWFpp) to VWF:Ag, robust response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b188df22aa25d34dfba24de5aeec7d
https://doi.org/10.1182/blood.v122.21.3571.3571
https://doi.org/10.1182/blood.v122.21.3571.3571
Publikováno v:
BMJ Neurology Open, Vol 3, Iss Suppl 1 (2021)
Externí odkaz:
https://doaj.org/article/41b240c0c27a44f3ac54dc53f4b11313
Autor:
Conor Owens-Walton, David Jakabek, Brian D Power, Mark Walterfang, Dennis Velakoulis, Danielle van Westen, Jeffrey C L Looi, Marnie Shaw, Oskar Hansson
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222002 (2019)
Parkinson's disease (PD) affects 2-3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unkno
Externí odkaz:
https://doaj.org/article/6bc516ae058c4e1ab18aaae793d05e56