Výsledky vyhledávání - "David J. de Gorter"

Abstract 336: Mechanism of action of MCLA-129, a bispecific antibody that targets EGFR and c-MET and impairs growth of EGFR exon 20 insertion mutant non-small cell lung cancer

Autor: David J. de Gorter, Marie O'Connor, Alexandre Deshiere, Martijn van Rosmalen, Szabolcs Fatrai, Jeroen Lammerts van Bueren, Cecile A. Geuijen

Publikováno v: Cancer Research. 82:336-336

Introduction: MCLA-129 is an ADCC-enhanced IgG1 bispecific antibody that targets epidermal growth factor receptor (EGFR) and c-MET. The HGF/c-MET pathway is frequently upregulated in tumors that are resistant to EGFR tyrosine kinase inhibitors (TKIs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca9dc8bb44c6dfd7ee67bd1d5c334ea3
https://doi.org/10.1158/1538-7445.am2022-336

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Abstract 952: The bispecific antibody MCLA-129 impairs NSCLC tumor growth by targeting EGFR and c-MET, inhibiting ligand-induced signaling and promoting ADCC and ADCP

Autor: Qingyu Shu, Liang Deng, Rinse Klooster, Wenxin Xu, Cecile Geuijen, John de Kruif, Li Mao, Wei Liu, Martijn van Rosmalen, Mark Throsby, Tristan Gallenne, David J. de Gorter, Mario Di Matteo, Alexandre Deshiere, Christian Wohn, Massimiliano Mazzone, Berina Eppink

Publikováno v: Cancer Research. 81:952-952

MCLA-129 is an ADCC-enhanced common light chain bispecific human IgG1 Biclonics® antibody specifically targeting the receptor tyrosine kinases EGFR and c-MET. It inhibits activation and downstream signaling of EGFR and c-MET induced by their respect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02db516a6d3a502f8247e3d00df0acc7
https://doi.org/10.1158/1538-7445.am2021-952

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