Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David J. Yeo"'
Autor:
David J, Ponting, Michael J, Burns, Robert S, Foster, Rachel, Hemingway, Grace, Kocks, Donna S, MacMillan, Andrew L, Shannon-Little, Rachael E, Tennant, Jessica R, Tidmarsh, David J, Yeo
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2425
Lhasa Limited have had a role in the in silico prediction of drug and other chemical toxicity for over 30 years. This role has always been multifaceted, both as a provider of predictive software such as Derek Nexus, and as an honest broker for the sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::628aa43e7d41070b9257927a51bf19f6
https://pubmed.ncbi.nlm.nih.gov/35188642
https://pubmed.ncbi.nlm.nih.gov/35188642
Autor:
David J. Ponting, Michael J. Burns, Robert S. Foster, Rachel Hemingway, Grace Kocks, Donna S. MacMillan, Andrew L. Shannon-Little, Rachael E. Tennant, Jessica R. Tidmarsh, David J. Yeo
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3e1b42066a75e0c6ba6e2e4ad73c202
https://doi.org/10.1007/978-1-0716-1960-5_17
https://doi.org/10.1007/978-1-0716-1960-5_17
Autor:
Amanda Giddings, James Harvey, Michael Kranz, Wolfgang Muster, Franck A. Atienzar, Susanne Glowienke, Krista L. Dobo, Helga Gerets, Lewis Whitehead, Magnus Wilhelm Walter, James Reuberson, Mukesh Patel, Mick D. Fellows, Joerg Wichard, Hans-Peter Spirkl, Michelle O. Kenyon, Steve Swallow, Jordi Munoz-Muriedas, Matt Selby, Alexander Amberg, Robert A. Jolly, Anne-Laure Werner, Andreas Sutter, Frank Bringezu, David J. Yeo, Russell Naven, Jacques Van Gompel
Publikováno v:
Computational Toxicology. 7:27-35
Primary aromatic amines (pAAs) are attractive building blocks in medicinal chemistry programmes yet their potential for mutagenic activity causes real concern owing to the risk of genotoxicity-related drug attrition. In addition, despite the existenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e54e6023b842ac8a6d60524200bd931
https://doi.org/10.1016/j.comtox.2018.06.002
https://doi.org/10.1016/j.comtox.2018.06.002
Autor:
George M. Burslem, Michael E. Webb, David J. Yeo, Jennifer A. Miles, Ludwig K. A. Pilsl, Zeynab Imani, Stuart L. Warriner, Claire M. Grison, Andrew J. Wilson
Publikováno v:
Chemical Science
A versatile, rapid and reversible approach to constrain peptides in a bioactive helical conformation and bearing a functional handle for inhibition of protein–protein interactions is described.
The development of constrained peptides for inhib
The development of constrained peptides for inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aadfefa07c28f0ab83ded14b533a954
https://doi.org/10.1039/c7sc01342f
https://doi.org/10.1039/c7sc01342f
Autor:
Silvia Rodriguez-Marin, David J. Yeo, Thomas A. Edwards, Jennifer A. Miles, Andrew J. Wilson, Christopher M. Pask, Stuart L. Warriner, Philip Rowell
Publikováno v:
Chemical Science
Biophysical studies on hydrocarbon constrained peptides reveal induced fit binding and enthalpy–entropy compensation on target protein recognition.
The development of constrained peptides represents an emerging strategy to generate peptide bas
The development of constrained peptides represents an emerging strategy to generate peptide bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71bac33840fff8af5f66cd5aff020fc
https://eprints.whiterose.ac.uk/96120/8/c5sc04048e.pdf
https://eprints.whiterose.ac.uk/96120/8/c5sc04048e.pdf
Autor:
Panchami Prabhakaran, George M. Burslem, Anna Barnard, Jennifer A. Miles, Thomas A. Edwards, Valeria Azzarito, David J. Yeo, Andrew J. Wilson, Kérya Long
Publikováno v:
Organic & Biomolecular Chemistry
We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using ‘click’ chemistry.
α-Helix mediated protein–protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class
α-Helix mediated protein–protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cc97fd49bc0effd2c0ad58aa992321
Publikováno v:
Chemical Communications. 49:9131
Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19f9d7cc905033389aa5e8e10e35703
https://doi.org/10.1039/c3cc45231j
https://doi.org/10.1039/c3cc45231j