Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David J. Valacer"'
Publikováno v:
Diabetes. 71
Background: RGT-075 is a small-molecule oral GLP-1 receptor agonist (GLP1RA) in clinical development. RGT-075 (15-280 mg) was well-tolerated by healthy adults in a prior phase 1 single ascending dose study. Phase 1 multiple-ascending dose study of RG
Autor:
David J. Valacer, Jack P. Higgins, Anas Younes, Paul A. Hamlin, Steven I. Park, Michelle A. Fanale
Publikováno v:
Blood. 128:4200-4200
Background Novel mechanisms of action (MOA) are needed for the treatment of NHL. Because of the ubiquity and persistence of CD20 expression in B-cell malignancies, there is strong rationale to develop novel MOAs targeting CD20. However, CD20's non-in
Publikováno v:
Pediatric Pulmonology. 23:62-65
Autor:
Catherine Diefenbach, Jack P. Higgins, David J. Valacer, Steven I. Park, Michelle A. Fanale, Paul A. Hamlin, Anas Younes
Publikováno v:
Cancer Research. 76:CT049-CT049
Background Anti-CD20 monoclonal antibody (MAb) therapy is widely employed in the treatment of non-Hodgkin's B-cell lymphoma (NHL), but most patients eventually become refractory to CD20 MAb(s). MT-3724 is a recombinant fusion protein consisting of a
Publikováno v:
Blood. 126:5112-5112
Background CD20 is selectively expressed on the surface of early pre-B-cells, remains throughout B-cell development, and is then lost from plasma cells. Because CD20 is present on the majority of B-cell lymphomas, anti-CD20 monoclonal antibody (MAb)
Publikováno v:
Pediatrics. 93:205-210
Objective. To evaluate the effects of aminophylline (Am) in children hospitalized with asthma. Methods. Prospective, randomized, double-blind, placebo-controlled trial. Subjects were children between the ages of 5 and 18 years admitted for asthma exa
Autor:
Stephen P. Peters, Craig A. Jones, David J. Valacer, Tmirah Haselkorn, Scott T. Weiss, David R. Mink
Publikováno v:
The Journal of allergy and clinical immunology. 119(6)
Background Despite health initiatives for advancing the management of asthma, evidence suggests that many asthmatic subjects have uncontrolled disease. However, the prevalence of uncontrolled asthma in the United States is not known and has not been
Publikováno v:
Pediatric pulmonology. 32(3)
This study sought to determine if a clinical pathway developed and executed by specialists in pediatric asthma would reduce hospital costs and length of stay (LOS). The study design was a retrospective, nonrandomized, controlled trial. Subjects were
Autor:
David J. Valacer
Publikováno v:
Drugs. 59
Asthma is common in children and its prevalence in this age group is increasing. While the reasons for this reported increase, and indeed the true magnitude of the increase, remain unclear, there can be no doubt that asthma is now a major health prob
Autor:
Mario Moreno, Susan E. Hart, John A. Barrett, David J. Valacer, William E. Fogler, Hagop Youssoufian, Tim Chan, Shelia Connelly, Mini Bharathan, Diaa Shakleya, Robert A. Morgan, Ronald B. Herberman, Selva R. Murugesan
Publikováno v:
Cancer Research. 72:4396-4396
A major obstacle for the development of effective immunotherapy is the ability of tumors to escape detection and/or destruction by the immune system. This study explored pairing a potent immunomodulatory cytokine (IL-12) with a bifunctional alkylatin