Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David J. Tyrrell"'
Autor:
Christopher Banks, David J. Tyrrell, Patricia D. Williams, Neal E. Storm, Kevin R. Holme Roula Salame
Publikováno v:
Toxicology Methods. 7:1-7
Summary: The pharmacological activity of heparin as a anti-inflammatory agent, has led to its proposed use in the treatment of asthma. However, the anticoagulant actions of heparin raise concerns about its long-term use due to potential bleeding comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6106df962a4712c4fb2f2701f8f93921
https://doi.org/10.1080/105172397243268
https://doi.org/10.1080/105172397243268
Publikováno v:
Advances in Pharmacology ISBN: 9780120329472
In this chapter we have described anti-inflammatory functions of heparin distinct from its traditional anticoagulant activity. We have presented in vivo data showing heparin's beneficial effects in various preclinical models of inflammatory disease a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6451ce7d45b6356846da8ee58b732e2
https://doi.org/10.1016/s1054-3589(08)60471-8
https://doi.org/10.1016/s1054-3589(08)60471-8
Autor:
France Lapierre, Kevin Holme, Lun Lam, Robert J. Tressler, Neil Storm, Jennifer Wee, Robert J. Stack, John Castellot, David J. Tyrrell
Publikováno v:
Glycobiology. 6(3)
Structural features of heparin potentially important for heparanase-inhibitory activity were examined by measuring the ability of heparin derivatives to affect the degradation of [3H]acetylated heparan sulphate by tumor cell heparanases. IC50 values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dab097389a0e9b34b6b1e4fbc17791a
https://pubmed.ncbi.nlm.nih.gov/8724143
https://pubmed.ncbi.nlm.nih.gov/8724143
Autor:
Robert J. Tressler, David J. Tyrrell, Jennifer Wee, J. J. Killion, Peter Fugedi, C. Peto, N. Storm, Robert J. Stack
Publikováno v:
Molecular, Cellular, and Clinical Aspects of Angiogenesis ISBN: 9781461380306
Angiogenesis is essential for solid tumor progression, growth and metastasis. This process requires mitogenic signals from growth factors for endothelial cell proliferation (eg. bFGF), as well as hydrolases for extracellular matrix degradation to per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39abca202fa16340d4676c33eec0bb3c
https://doi.org/10.1007/978-1-4613-0389-3_19
https://doi.org/10.1007/978-1-4613-0389-3_19
Publikováno v:
Analytical biochemistry. 202(2)
A simple panning procedure that allows for the evaluation of interactions between various heparin-like molecules and basic FGF has been developed. This assay measures the ability of compounds to inhibit the interaction of transfected human lymphoblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e240271304d1688441b86105696c62c2
https://pubmed.ncbi.nlm.nih.gov/1519758
https://pubmed.ncbi.nlm.nih.gov/1519758