Zobrazeno 1 - 10
of 17
pro vyhledávání: '"David J. Sellers"'
Autor:
Christopher M. Timperley, David J. Sellers, Stuart Notman, Krystal E. Casey, Gareth R. Williams, Nancy E. Williams, Nichola H. Williams
Publikováno v:
Journal of Fluorine Chemistry. 127:1554-1563
Eighteen new fluorogenic analogues of organophosphorus nerve agents were synthesised and characterised. They included analogues of tabun, sarin, cyclosarin, soman, VX, and Russian VX, with the 7-oxy-4-methylcoumarin or 7-oxy-4-(trifluoromethyl)coumar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480b0825bc8b336c96e2cabada64afd4
https://doi.org/10.1016/j.jfluchem.2006.07.017
https://doi.org/10.1016/j.jfluchem.2006.07.017
Autor:
Michael Bird, David J. Sellers, Malcolm W. Parry, Robert E. Arbon, Colin R. Willis, Stuart Anson Brewer, Christopher M. Timperley
Publikováno v:
Journal of Fluorine Chemistry. 121:23-31
Ten fluoromonomers of structure (RFO)2P(O)OCH2CH2OC(O)CRCH2 were made in 30–64% yield by treating the chloridates (RFO)2P(O)Cl with HOCH2CH2OC(O)CRCH2 in chloroform in the presence of triethylamine [RF=CF3CH2, C2F5CH2, C3F7CH2, C4F9CH2, C4F9C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3df615f5abbf69e85efe7ecfee62501c
https://doi.org/10.1016/s0022-1139(02)00314-7
https://doi.org/10.1016/s0022-1139(02)00314-7
Publikováno v:
Journal of Fluorine Chemistry. 107:155-158
Whilst examining the chemistry of a series of tris(fluoroalkyl) phosphates as potential fire retardants, concern was raised over their possible anticholinesterase activity. Bimolecular rate constants ( k i values) for the inhibition of bovine erythro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed0135762708a423f018b8d972bacd1
https://doi.org/10.1016/s0022-1139(00)00394-8
https://doi.org/10.1016/s0022-1139(00)00394-8
Autor:
James Hill, Janet Wetherell, and Alan R. Fersht, Christopher M. Timperley, Gareth R. Williams, Andrew D. Griffiths, Stuart Notman, Andy P. Smith, Nichola H. Williams, Luis Briseño-Roa, David J. Sellers
Publikováno v:
Journal of medicinal chemistry. 49(1)
Enzymes that efficiently hydrolyze highly toxic organophosphorus nerve agents could potentially be used as medical countermeasures. As sufficiently active enzymes are currently unknown, we synthesized twelve fluorogenic analogues of organophosphorus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b8c5864f428e6d8f9e313a79fbe2f
https://pubmed.ncbi.nlm.nih.gov/16392809
https://pubmed.ncbi.nlm.nih.gov/16392809
Publikováno v:
Biochemical Pharmacology. 35:745-751
The y in vitro reactivation profiles of O , O -diethyl phosphorylated ACh E and O -ethyl methyl phosphonylated AChE by P2S (2-hydroxy iminomethyl-1-methyl-pyridinium methane sulphonate) have been determined. Whilst reinhibition of the reactivated ACh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3fcfd48fa43f247c7045f3e37e56db8
https://doi.org/10.1016/0006-2952(86)90241-8
https://doi.org/10.1016/0006-2952(86)90241-8
Autor:
D. G. Upshall, M. C. French, David J. Sellers, C. R. Hall, Thomas D. Inch, Andrew P. Smith, J. M. Harrison, P. Watts
Publikováno v:
Pesticide Biochemistry and Physiology. 24:53-60
R (+)-Ethyl S -propyl methylphosphonothioate is bioactivated both in vivo and when perfused through isolated liver to give a product which is much more active as an inhibitor of acetylcholinesterase than the parent compound. The bioactivation does no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e85a1cf7612a3525fc005d6cf0f8a036
https://doi.org/10.1016/0048-3575(85)90113-0
https://doi.org/10.1016/0048-3575(85)90113-0
Publikováno v:
Biochemical Pharmacology. 35:737-744
The rates of formation and decomposition of a series of phosphylated oximes derived from P2S (2-hydroxy-iminomethyl-1-methylpyridinium methane-sulphonate) have been measured. The rates of inhibition of AChE by these phosphylated oximes and the parent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2450c8d9b7dcad6b1833b0a3498ca05a
https://doi.org/10.1016/0006-2952(86)90240-6
https://doi.org/10.1016/0006-2952(86)90240-6
Publikováno v:
Biochemical Pharmacology. 32:787-793
A study of the mechanism of interaction of acetylcholinesterase with some simple tetra-N-alkyammonium ions has been made. Kinetic schemes have been proposed which are consistent with the experimental results observed in the enzyme-tetra-N-alkylammoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431e09692b8de33bc678aadb91d10f6b
https://doi.org/10.1016/0006-2952(83)90577-4
https://doi.org/10.1016/0006-2952(83)90577-4
Publikováno v:
International Journal of Clinical and Experimental Hypnosis. 16:26-37
The probability that hypnotic induction produces psycho-pathological effects has not been experimentally determined. The present study hypothesizes various negative effects following hypnosis such as increased signs of personality disturbances, incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36207a0c163d5b75cd34bb8eac40fc4
https://doi.org/10.1080/00207146808407531
https://doi.org/10.1080/00207146808407531
Publikováno v:
Tetrahedron Letters. 12:2329-2332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56f0d7de9bd442e593597561f0fc026f
https://doi.org/10.1016/s0040-4039(01)96854-6
https://doi.org/10.1016/s0040-4039(01)96854-6