Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David J. Schwalb"'
Autor:
David R. Janero, Michael C. Warren, Roseanne S. Wexler, Matthew J. Shumway, Vijay Dhawan, Brian M. Zifcak, David J. Schwalb, Irina S. Zemtseva
Publikováno v:
Free Radical Biology and Medicine. 39:1191-1207
Nitric oxide (NO) enhances anti-inflammatory drug action. Through a metabonomics approach termed "NObonomics," the effects of a prototypic NO donor (organic nitrate)-cyclooxygenase-2 inhibitor hybrid (NO-coxib), NMI-1093, on the NO metabolite status
Autor:
Irina S. Zemtseva, Michael E. Augustyniak, Allison M. Martino, Richard A. Earl, Delano V. Young, L. Gordon Letts, Madhavi G. Murty, Matthew J. Shumway, David S. Garvey, David J. Schwalb, Subhash P. Khanapure, Andrzej M. Trocha, David R. Janero
Publikováno v:
Journal of Medicinal Chemistry. 48:3930-3934
Incorporation of a spacer group between the central scaffold and the aryl ring resulted in a new cyclooxygenase-2 (COX-2) selective inhibitor core structure, 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone (20), with COX-2 I
Autor:
William M. Selig, Laura J. Gordon, Terry L. Melim, L. Gordon Letts, David J. Schwalb, Irina S. Zemtseva, David R. Janero, Delano V. Young, Michael E. Augustyniak, Edward Cochran, Richard A. Earl, Madhavi G. Murty, Subhash P. Khanapure, David S. Garvey, James L. Ellis, Matthew J. Shumway, A. Mark Trocha
Publikováno v:
Inflammopharmacology. 12(5-6)
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat inflammation and to provide pain relief but suffer from a major liability concerning their propensity to cause gastric damage. As nitric oxide (NO) is known to be gastro-protecti
Autor:
Nathan S. Bryan, David J. Schwalb, David R. Janero, Vijay Dhawan, Martin Feelisch, Fumito Saijo, Michael C. Warren
Nitric oxide (NO)-derived products may modify tissue constituents, forming S - and N -nitroso adducts and metal nitrosyls implicated in NO signaling. Nitrovasodilator drugs have been in widespread use for more than a century, yet their biotransformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7613739eb7d9d6f66be4e8ce290092c1
https://europepmc.org/articles/PMC534729/
https://europepmc.org/articles/PMC534729/
Autor:
Nathan S. Bryan, Vijay Dhawan, Martin Feelisch, Michael C. Warren, David R. Janero, A. Mark Trocha, Fumito Saijo, Michael E. Augustyniak, David J. Schwalb
Publikováno v:
Nitric Oxide. 14:41