Zobrazeno 1 - 10
of 28
pro vyhledávání: '"David J. Schenk"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:391-397
Speeding the analysis of reaction aliquots, high-performance liquid chromatography (HPLC) fractions and final products continue to be an area of great interest in the study of radiopharmaceuticals. Translating recently developed rapid HPLC and ultra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e80f549e3ece9ad107628d38b7c411
https://doi.org/10.1002/jlcr.3422
https://doi.org/10.1002/jlcr.3422
Autor:
Elizabeth Joshi, Zhizhen Zeng, Joseph Della Rocca, David J. Schenk, Jeffrey L. Evelhoch, Idriss Bennacef, Abbas Walji, Hyking Haley, Mona Purcell, Kerry Riffel, Serena Xu, Marie A. Holahan, Paul J. Coleman, Eric D. Hostetler, Talakad G. Lohith, Aileen Soriano, Brett Connolly, Liza Gantert, Patricia Miller, Cristian Salinas, Xiaoping Zhang, Aimie Ogawa, David Hesk
Publikováno v:
Journal of Nuclear Medicine. 57:1599-1606
A PET tracer is desired to help guide the discovery and development of disease-modifying therapeutics for neurodegenerative diseases characterized by neurofibrillary tangles (NFTs), the predominant tau pathology in Alzheimer disease (AD). We describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8733806d8e7d47383df5f2187ef2941
https://doi.org/10.2967/jnumed.115.171678
https://doi.org/10.2967/jnumed.115.171678
Autor:
Patricia Miller, Yaode Wang, Joseph Della Rocca, Jeffrey L. Evelhoch, Paul J. Coleman, Kerry Riffel, Zhizhen Zeng, Elizabeth Joshi, Kun Yang, Xiaoping Zhang, Kerim Babaoglu, Eric D. Hostetler, Talakad G. Lohith, Stacey O'Malley, David Hesk, Abbas Walji, Jaume Balsells, Mona Purcell, Jing Li, Serena Xu, Brett Connolly, Stacey Melquist, Arie Struyk, Jianmin Fu, Julie A. O'Brien, Marie A. Holahan, Harold G. Selnick, Fred Hess, Aimie Ogawa, David J. Schenk, Idriss Bennacef, Cristian Salinas, Joel B. Schachter, Aileen Soriano, Liza Gantert
Publikováno v:
Journal of Medicinal Chemistry. 59:4778-4789
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. In vivo detection of NFTs using PET imaging represents a unique oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39b60a8ba41ad44ebe7487bf9b6714d
https://doi.org/10.1021/acs.jmedchem.6b00166
https://doi.org/10.1021/acs.jmedchem.6b00166
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:136-146
When the isotopic abundance or specific activity of a labeled compound is determined by mass spectrometry (MS), it is necessary to correct the raw MS data to eliminate ion intensity contributions, which arise from the presence of heavy isotopes at na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb8922fbf23299d682cfd1a1a94864e
https://doi.org/10.1002/jlcr.3370
https://doi.org/10.1002/jlcr.3370
Autor:
Scott R. Pollack, David J. Schenk
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:433-441
Omeprazole (Prilosec®) is a selective and irreversible proton pump inhibitor used to treat various medical conditions related to the production of excess stomach acids. It functions by suppressing secretion of those acids. Radiolabeled compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::627b2bcc755bb5196fe7ec9fdbdd4a39
https://doi.org/10.1002/jlcr.3346
https://doi.org/10.1002/jlcr.3346
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:291-298
Compounds containing tritium are widely used across the drug discovery and development landscape. These materials are widely utilized because they can be efficiently synthesized and produced at high specific activity. Results from internally calibrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb21ab586f1fb7ea7dcc0329f7e9ef5a
https://doi.org/10.1002/jlcr.3295
https://doi.org/10.1002/jlcr.3295
Autor:
Jeffrey C. Moore, Nelo R. Rivera, David J. Schenk, Heather Wang, Ingrid Mergelsberg, David Hesk
Publikováno v:
Tetrahedron Letters. 57:1090-1092
Isotopically labeled compounds have numerous applications in drug discovery and development. (R)-9-(2-Hydroxypropyl)adenine 1 is an important intermediate in the synthesis of various acyclic nucleoside phosphonates including tenofovir. We have develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1357d1a7f2d78ae9e117cdeee63591f9
https://doi.org/10.1016/j.tetlet.2016.01.087
https://doi.org/10.1016/j.tetlet.2016.01.087
Autor:
Brett Connolly, Jeffrey L. Evelhoch, Wenping Li, David J. Schenk, Zhizhen Zeng, Talakad G. Lohith, James Mulhearn, Stacey O'Malley, David Hesk, Idriss Bennacef, Eric D. Hostetler, Patricia Miller, Abbas Walji, Cyrille Sur
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb09911c8cd974217e8cc25ffd0f8e9b
https://doi.org/10.1016/j.jalz.2017.06.1920
https://doi.org/10.1016/j.jalz.2017.06.1920
Autor:
Zhizhen Zeng, Patricia J. Miller, Brett M. Connolly, Stacey S. O'Malley, Talakad Lohith, Idriss Bennacef, James Mulhearn, David J. Schenk, David Hesk, Abbas Walji, Cyrille Sur, Wenping Li, Eric D. Hostetler, Jeffrey Evelhoch
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d6566f3d4bf9e1ffa3047169ae3c9d
https://doi.org/10.1016/j.jalz.2017.06.2583
https://doi.org/10.1016/j.jalz.2017.06.2583
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:645-651
The specific activity (SA) values determined using two different methods were compared for a set of tritium-labeled and carbon-14-labeled compounds. The methods employed were as follows: (a) liquid chromatography/mass spectrometry (LC/MS) isotopic pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab509750ff62d8e29d38dc0e98cb25a4
https://doi.org/10.1002/jlcr.3234
https://doi.org/10.1002/jlcr.3234