Zobrazeno 1 - 10
of 217
pro vyhledávání: '"David J. Rowlands"'
Autor:
Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Cryo-EM structures reveal the role of glutathione (GSH) in poliovirus (PV) serotype 3 virus-like particle (VLP) stability, suggesting GSH or an analogous tight-binding antiviral offers potential for stabilizing VLP vaccines against PV.
Externí odkaz:
https://doaj.org/article/0d5db9da35ca49d08e79312c5f1dc633
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens. Virus-like particles (VLPs) form the basis of two of the most successful licensed vaccin
Externí odkaz:
https://doaj.org/article/b7c301ef9e3a4446bd7a97505024123b
Autor:
Lee Sherry, Jessica J. Swanson, Keith Grehan, Huijun Xu, Mai Uchida, Ian M. Jones, Nicola J. Stonehouse, David J. Rowlands
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The production of enterovirus virus-like particles (VLPs) that lack the viral genome have great potential as vaccines for a number of diseases, such as poliomyelitis and hand, foot, and mouth disease. These VLPs can mimic empty capsids, whic
Externí odkaz:
https://doaj.org/article/83e091e831884d0a9588bca688904466
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mona Shegdar, Helen Fox, Andrew J. Macadam, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Enterovirus A71 (EVA71) is a medically important virus that is commonly associated with hand, foot, and mouth disease (HFMD). It is responsible for periodic outbreaks, resulting in significant economic impact and loss of life. Vaccination of
Externí odkaz:
https://doaj.org/article/2ef97b3af6e44c7293cd043c6395f5a8
Autor:
Joseph S. Snowden, Jehad Alzahrani, Lee Sherry, Martin Stacey, David J. Rowlands, Neil A. Ranson, Nicola J. Stonehouse
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Type I fatty acid synthases (FASs) are critical metabolic enzymes which are common targets for bioengineering in the production of biofuels and other products. Serendipitously, we identified FAS as a contaminant in a cryoEM dataset of virus-
Externí odkaz:
https://doaj.org/article/ea134c6e98c5470c870f579a6a29ef67
Autor:
Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/747ed033b5d14c2baff8e310a56a1ac0
Autor:
Lee Sherry, Keith Grehan, Jessica J. Swanson, Mohammad W. Bahar, Claudine Porta, Elizabeth E. Fry, David I. Stuart, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
Viruses, Vol 14, Iss 10, p 2159 (2022)
Following the success of global vaccination programmes using the live-attenuated oral and inactivated poliovirus vaccines (OPV and IPV), wild poliovirus (PV) is now only endemic in Afghanistan and Pakistan. However, the continued use of these vaccine
Externí odkaz:
https://doaj.org/article/d8131386c99946418b17811bbf258c55
Autor:
Szczepan W. Baran, Ayan Das Gupta, Maria A. Lim, Ashwini Mathur, David J. Rowlands, Laura R. Schaevitz, Shiva K. Shanmukhappa, Dana B. Walker
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Assessments of respiratory response and animal activity are useful endpoints in drug pharmacology and safety research. We investigated whether continuous, direct monitoring of breathing rate and body motion in animals in the home cage using the Vum D
Externí odkaz:
https://doaj.org/article/3b33a2f40f484891a9c601e0ab928f3e
Autor:
Lee Sherry, Keith Grehan, Joseph S. Snowden, Michael L. Knight, Oluwapelumi O. Adeyemi, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 5, Iss 2 (2020)
ABSTRACT For enteroviruses such as poliovirus (PV), empty capsids, which are antigenically indistinguishable from mature virions, are produced naturally during viral infection. The production of such capsids recombinantly, in heterologous systems suc
Externí odkaz:
https://doaj.org/article/488d04d86fa140579e59ec88d5d3ee47
Autor:
Andris Kazaks, I-Na Lu, Sophie Farinelle, Alex Ramirez, Vincenzo Crescente, Benjamin Blaha, Olotu Ogonah, Tarit Mukhopadhyay, Mapi Perez de Obanos, Alejandro Krimer, Inara Akopjana, Janis Bogans, Velta Ose, Anna Kirsteina, Tatjana Kazaka, Nicola J. Stonehouse, David J. Rowlands, Claude P. Muller, Kaspars Tars, William M. Rosenberg
Publikováno v:
BMC Biotechnology, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background The lack of a universal influenza vaccine is a global health problem. Interest is now focused on structurally conserved protein domains capable of eliciting protection against a broad range of influenza virus strains. The long alp
Externí odkaz:
https://doaj.org/article/e6429490dc22453698b74940fe830a21