Zobrazeno 1 - 10
of 65
pro vyhledávání: '"David J. Roush"'
Autor:
Sobhana Alekhya Sripada, Wenning Chu, Taufika Islam Williams, Matthew A. Teten, Brian J. Mosley, Ruben G. Carbonell, Abraham M. Lenhoff, Steven M. Cramer, Jerome Bill, Yinges Yigzaw, David J. Roush, Stefano Menegatti
Publikováno v:
Biotechnology and Bioengineering. 119:1873-1889
The growth of advanced analytics in manufacturing monoclonal antibodies (mAbs) has highlighted the challenges associated with the clearance of host cell proteins (HCPs). Of special concern is the removal of "persistent" HCPs, including immunogenic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7635790d7340f8d2099455bdb13d469
https://doi.org/10.1002/bit.28096
https://doi.org/10.1002/bit.28096
Publikováno v:
Antibody Therapeutics. 5:42-54
Nonionic surfactant polysorbates, including PS-80 and PS-20, are commonly used in the formulation of biotherapeutic products for both preventing surface adsorption and acting as stabilizer against protein aggregation. Trace levels of residual host ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bbb8c05a401eca09a9ca2b2b379fea
https://doi.org/10.1093/abt/tbac002
https://doi.org/10.1093/abt/tbac002
Autor:
Young Hoon Oh, Matthew L. Becker, Kerri M. Mendola, Leila H. Choe, Lie Min, Kelvin H. Lee, Yinges Yigzaw, Alexander Seay, Jerome Bill, Xuanwen Li, David J. Roush, Steven M. Cramer, Stefano Menegatti, Abraham M. Lenhoff
Publikováno v:
Biotechnology and bioengineering.
In the production of biopharmaceuticals such as monoclonal antibodies (mAbs) and vaccines, the residual amounts of host-cell proteins (HCPs) are among the critical quality attributes. In addition to overall HCP levels, individual HCPs may elude purif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9628e711fe90e567952f681011b1457e
https://pubmed.ncbi.nlm.nih.gov/36585356
https://pubmed.ncbi.nlm.nih.gov/36585356
Autor:
Mayank Vats, Mark A. McCoy, Steven M. Cramer, David J. Roush, Mark A. Snyder, Scott A. McCallum, Camille L. Bilodeau, Ronak B. Gudhka
Publikováno v:
Langmuir. 37:12188-12203
In this study, NMR and molecular dynamics simulations were employed to study IgG1 FC binding to multimodal surfaces. Gold nanoparticles functionalized with two multimodal cation-exchange ligands (Capto and Nuvia) were synthesized and employed to carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bcbb6df5942fd86b3485270bbd58b98
https://doi.org/10.1021/acs.langmuir.1c02114
https://doi.org/10.1021/acs.langmuir.1c02114
Autor:
Rushd Khalaf, Neil Mody, Bruno F. Marques, Steven M. Cramer, Christopher D. Afdahl, Richard C. Willson, Jennifer M. Pollard, Eike Zimmermann, Jan Griesbach, Divya Chandra, Charles A. Haynes, Kannan Sankar, Ujwal Patil, Jonathan Coffman, Hasan Mohammad, Joelle Khouri, Minni Aswath, Jasper C. Lin, Lars Pampel, Alexander Hanke, Siddharth Parimal, David J. Roush, Francis Insaidoo, Saeed Izadi, Raquel Orozco, Soundara Soundararajan, Nihal Tugcu, Gisela Ferreira, Tingting Cui, John P. Welsh, Jainik Panchal, Ambrose Williams, Stefan Hepbildikler, Xuan Hong, Julie Robinson, Marco A. Blanco, John E. Schiel, Jared A. Delmar, Benjamin T. Walters
Publikováno v:
Biotechnology and Bioengineering. 117:2100-2115
Biopharmaceutical product and process development do not yet take advantage of predictive computational modeling to nearly the degree seen in industries based on smaller molecules. To assess and advance progress in this area, spirited coopetition (mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2691f1fe3ec2b1fe3233cd79e9f3b84d
https://doi.org/10.1002/bit.27349
https://doi.org/10.1002/bit.27349
Autor:
Negin Nejatishahidein, Minyoung Kim, Seon Y. Jung, Ehsan E. Borujeni, Lara Fernandez‐Cerezo, David J. Roush, Ali Borhan, Andrew L. Zydney
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(4)
Significant increases in cell density and product titer have led to renewed interest in the application of depth filtration for initial clarification of cell culture fluid in antibody production. The performance of these depth filters will depend on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3949232d30df9f8d2342da616c7232e
https://pubmed.ncbi.nlm.nih.gov/35032027
https://pubmed.ncbi.nlm.nih.gov/35032027
Autor:
Ronak B, Gudhka, Mayank, Vats, Camille L, Bilodeau, Scott A, McCallum, Mark A, McCoy, David J, Roush, Mark A, Snyder, Steven M, Cramer
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 37(41)
In this study, NMR and molecular dynamics simulations were employed to study IgG1 F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3f83f31ca27ca9520e1104d380ac350
https://pubmed.ncbi.nlm.nih.gov/34633195
https://pubmed.ncbi.nlm.nih.gov/34633195
Publikováno v:
Langmuir. 35:16770-16779
Multimodal chromatography is a powerful tool which uses multiple modes of interaction, such as charge and hydrophobicity, to purify protein-based therapeutics. In this work, we performed molecular dynamics simulations of a series of multimodal cation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0924b79f0de59a324dbfab151eb5c340
https://doi.org/10.1021/acs.langmuir.9b01925
https://doi.org/10.1021/acs.langmuir.9b01925
Retrospective Evaluation of Cycled Resin in Viral Clearance Studies—A Multiple Company Collaboration
Autor:
Jeremy Pike, Norbert Schuelke, Mike Clark, Deqiang Yu, Scott Tobler, Yenny Webb-Vargas, Bradford Stanley, Sherrie Curtis, Olga Galperina, Eileen Wilson, David J. Roush, Xinfang Li, Johanna Kindermann, John Mattila, Andreas Flicker, Louise Bennett, Justin Weaver, Richard Whitcombe
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 73:470-486
The BioPhorum Development Group Viral Clearance Workstream performed a collaborative retrospective analysis to evaluate packed bed chromatographic resin performance after repeated cycling for two commonly used chromatography steps in biopharmaceutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480e07d786d32f8c0e0f5799fc9f195c
https://doi.org/10.5731/pdajpst.2018.009605
https://doi.org/10.5731/pdajpst.2018.009605
Autor:
Mark A. Snyder, Scott A. McCallum, Camille L. Bilodeau, Steven M. Cramer, Ronak B. Gudhka, David J. Roush, Mark A. McCoy
In this study, the binding of multimodal chromatographic ligands to the IgG1 FC domain were studied using nuclear magnetic resonance and molecular dynamics simulations. Nuclear magnetic resonance experiments carried out with chromatographic ligands a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dc25ffad3e5586071bac497f695c1a6
https://doi.org/10.22541/au.159611515.59404427
https://doi.org/10.22541/au.159611515.59404427
